A genome-scale metabolic model of Saccharomyces cerevisiae that integrates expression constraints and reaction thermodynamics

Formulating metabolic networks mathematically can help researchers study metabolic diseases and optimize the production of industrially important molecules. Here, the authors propose a framework that allows to model eukaryotic metabolism considering gene expression and thermodynamic constraints.

Guardado en:

Detalles Bibliográficos
Autores principales:	Omid Oftadeh, Pierre Salvy, Maria Masid, Maxime Curvat, Ljubisa Miskovic, Vassily Hatzimanikatis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6a2e860a1f4d4e6f8e04de3cbd18266b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6a2e860a1f4d4e6f8e04de3cbd18266b
record_format	dspace
spelling	oai:doaj.org-article:6a2e860a1f4d4e6f8e04de3cbd18266b2021-12-02T16:27:51ZA genome-scale metabolic model of Saccharomyces cerevisiae that integrates expression constraints and reaction thermodynamics10.1038/s41467-021-25158-62041-1723https://doaj.org/article/6a2e860a1f4d4e6f8e04de3cbd18266b2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25158-6https://doaj.org/toc/2041-1723Formulating metabolic networks mathematically can help researchers study metabolic diseases and optimize the production of industrially important molecules. Here, the authors propose a framework that allows to model eukaryotic metabolism considering gene expression and thermodynamic constraints.Omid OftadehPierre SalvyMaria MasidMaxime CurvatLjubisa MiskovicVassily HatzimanikatisNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Omid Oftadeh Pierre Salvy Maria Masid Maxime Curvat Ljubisa Miskovic Vassily Hatzimanikatis A genome-scale metabolic model of Saccharomyces cerevisiae that integrates expression constraints and reaction thermodynamics
description	Formulating metabolic networks mathematically can help researchers study metabolic diseases and optimize the production of industrially important molecules. Here, the authors propose a framework that allows to model eukaryotic metabolism considering gene expression and thermodynamic constraints.
format	article
author	Omid Oftadeh Pierre Salvy Maria Masid Maxime Curvat Ljubisa Miskovic Vassily Hatzimanikatis
author_facet	Omid Oftadeh Pierre Salvy Maria Masid Maxime Curvat Ljubisa Miskovic Vassily Hatzimanikatis
author_sort	Omid Oftadeh
title	A genome-scale metabolic model of Saccharomyces cerevisiae that integrates expression constraints and reaction thermodynamics
title_short	A genome-scale metabolic model of Saccharomyces cerevisiae that integrates expression constraints and reaction thermodynamics
title_full	A genome-scale metabolic model of Saccharomyces cerevisiae that integrates expression constraints and reaction thermodynamics
title_fullStr	A genome-scale metabolic model of Saccharomyces cerevisiae that integrates expression constraints and reaction thermodynamics
title_full_unstemmed	A genome-scale metabolic model of Saccharomyces cerevisiae that integrates expression constraints and reaction thermodynamics
title_sort	genome-scale metabolic model of saccharomyces cerevisiae that integrates expression constraints and reaction thermodynamics
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6a2e860a1f4d4e6f8e04de3cbd18266b
work_keys_str_mv	AT omidoftadeh agenomescalemetabolicmodelofsaccharomycescerevisiaethatintegratesexpressionconstraintsandreactionthermodynamics AT pierresalvy agenomescalemetabolicmodelofsaccharomycescerevisiaethatintegratesexpressionconstraintsandreactionthermodynamics AT mariamasid agenomescalemetabolicmodelofsaccharomycescerevisiaethatintegratesexpressionconstraintsandreactionthermodynamics AT maximecurvat agenomescalemetabolicmodelofsaccharomycescerevisiaethatintegratesexpressionconstraintsandreactionthermodynamics AT ljubisamiskovic agenomescalemetabolicmodelofsaccharomycescerevisiaethatintegratesexpressionconstraintsandreactionthermodynamics AT vassilyhatzimanikatis agenomescalemetabolicmodelofsaccharomycescerevisiaethatintegratesexpressionconstraintsandreactionthermodynamics AT omidoftadeh genomescalemetabolicmodelofsaccharomycescerevisiaethatintegratesexpressionconstraintsandreactionthermodynamics AT pierresalvy genomescalemetabolicmodelofsaccharomycescerevisiaethatintegratesexpressionconstraintsandreactionthermodynamics AT mariamasid genomescalemetabolicmodelofsaccharomycescerevisiaethatintegratesexpressionconstraintsandreactionthermodynamics AT maximecurvat genomescalemetabolicmodelofsaccharomycescerevisiaethatintegratesexpressionconstraintsandreactionthermodynamics AT ljubisamiskovic genomescalemetabolicmodelofsaccharomycescerevisiaethatintegratesexpressionconstraintsandreactionthermodynamics AT vassilyhatzimanikatis genomescalemetabolicmodelofsaccharomycescerevisiaethatintegratesexpressionconstraintsandreactionthermodynamics
_version_	1718383994876198912

A genome-scale metabolic model of Saccharomyces cerevisiae that integrates expression constraints and reaction thermodynamics

Ejemplares similares