Therapeutic Effect of Schistosoma japonicum Cystatin on Atherosclerotic Renal Damage
Atherosclerosis is a chronic inflammation of the arterial vessel wall driven by lipid metabolism disorders. Although helminthic infection and their derivatives have been identified to attenuate the chronic inflammatory diseases, the immunomodulatory effect of recombinant Schistosoma japonicum cystat...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Frontiers Media S.A.
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/6a31636123e34b7785334ad873a4b560 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:6a31636123e34b7785334ad873a4b560 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:6a31636123e34b7785334ad873a4b5602021-12-01T01:52:13ZTherapeutic Effect of Schistosoma japonicum Cystatin on Atherosclerotic Renal Damage2296-634X10.3389/fcell.2021.760980https://doaj.org/article/6a31636123e34b7785334ad873a4b5602021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.760980/fullhttps://doaj.org/toc/2296-634XAtherosclerosis is a chronic inflammation of the arterial vessel wall driven by lipid metabolism disorders. Although helminthic infection and their derivatives have been identified to attenuate the chronic inflammatory diseases, the immunomodulatory effect of recombinant Schistosoma japonicum cystatin (rSj-Cys) on metabolic diseases and atherosclerosis has not been reported. In this study, we investigated the therapeutic efficacy of rSj-Cys on atherosclerotic renal damage and explored the related immunological mechanism. The results demonstrated that treatment with rSj-Cys significantly reduced body weight gain, hyperlipidemia, and atherosclerosis induced by the high-fat diet in apoE–/– mice. The treatment of rSj-Cys also significantly improved kidney functions through promoting macrophage polarization from M1 to M2, therefore inhibiting M1 macrophage–induced inflammation. The possible mechanism underlying the regulatory effect of rSj-Cys on reducing atherosclerosis and atherosclerotic renal damage is that rSj-Cys stimulates regulatory T cell and M2 macrophage polarization that produce regulatory cytokines, such as interleukin 10 and transforming growth factor β. The therapeutic effect of rSj-Cys on atherosclerotic renal damage is possibly through inhibiting the activation of TLR2/Myd88 signaling pathway. The results in this study provide evidence for the first time that Schistosoma-derived cystatin could be developed as a therapeutic agent to treat lipid metabolism disorder and atherosclerosis that threats million lives around the world.Huijuan YangHuijuan YangHongqi LiWeidong ChenZhijie MeiYuan YuanYuan YuanXiaoli WangXiaoli WangLiang ChuYu XuYu XuYan SunYan SunDingru LiDingru LiHongyu GaoHongyu GaoBin ZhanHuihui LiHuihui LiXiaodi YangXiaodi YangFrontiers Media S.A.articlecystatinSchistosoma japonicumatherosclerosisrenalimmunoregulationBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
cystatin Schistosoma japonicum atherosclerosis renal immunoregulation Biology (General) QH301-705.5 |
| spellingShingle |
cystatin Schistosoma japonicum atherosclerosis renal immunoregulation Biology (General) QH301-705.5 Huijuan Yang Huijuan Yang Hongqi Li Weidong Chen Zhijie Mei Yuan Yuan Yuan Yuan Xiaoli Wang Xiaoli Wang Liang Chu Yu Xu Yu Xu Yan Sun Yan Sun Dingru Li Dingru Li Hongyu Gao Hongyu Gao Bin Zhan Huihui Li Huihui Li Xiaodi Yang Xiaodi Yang Therapeutic Effect of Schistosoma japonicum Cystatin on Atherosclerotic Renal Damage |
| description |
Atherosclerosis is a chronic inflammation of the arterial vessel wall driven by lipid metabolism disorders. Although helminthic infection and their derivatives have been identified to attenuate the chronic inflammatory diseases, the immunomodulatory effect of recombinant Schistosoma japonicum cystatin (rSj-Cys) on metabolic diseases and atherosclerosis has not been reported. In this study, we investigated the therapeutic efficacy of rSj-Cys on atherosclerotic renal damage and explored the related immunological mechanism. The results demonstrated that treatment with rSj-Cys significantly reduced body weight gain, hyperlipidemia, and atherosclerosis induced by the high-fat diet in apoE–/– mice. The treatment of rSj-Cys also significantly improved kidney functions through promoting macrophage polarization from M1 to M2, therefore inhibiting M1 macrophage–induced inflammation. The possible mechanism underlying the regulatory effect of rSj-Cys on reducing atherosclerosis and atherosclerotic renal damage is that rSj-Cys stimulates regulatory T cell and M2 macrophage polarization that produce regulatory cytokines, such as interleukin 10 and transforming growth factor β. The therapeutic effect of rSj-Cys on atherosclerotic renal damage is possibly through inhibiting the activation of TLR2/Myd88 signaling pathway. The results in this study provide evidence for the first time that Schistosoma-derived cystatin could be developed as a therapeutic agent to treat lipid metabolism disorder and atherosclerosis that threats million lives around the world. |
| format |
article |
| author |
Huijuan Yang Huijuan Yang Hongqi Li Weidong Chen Zhijie Mei Yuan Yuan Yuan Yuan Xiaoli Wang Xiaoli Wang Liang Chu Yu Xu Yu Xu Yan Sun Yan Sun Dingru Li Dingru Li Hongyu Gao Hongyu Gao Bin Zhan Huihui Li Huihui Li Xiaodi Yang Xiaodi Yang |
| author_facet |
Huijuan Yang Huijuan Yang Hongqi Li Weidong Chen Zhijie Mei Yuan Yuan Yuan Yuan Xiaoli Wang Xiaoli Wang Liang Chu Yu Xu Yu Xu Yan Sun Yan Sun Dingru Li Dingru Li Hongyu Gao Hongyu Gao Bin Zhan Huihui Li Huihui Li Xiaodi Yang Xiaodi Yang |
| author_sort |
Huijuan Yang |
| title |
Therapeutic Effect of Schistosoma japonicum Cystatin on Atherosclerotic Renal Damage |
| title_short |
Therapeutic Effect of Schistosoma japonicum Cystatin on Atherosclerotic Renal Damage |
| title_full |
Therapeutic Effect of Schistosoma japonicum Cystatin on Atherosclerotic Renal Damage |
| title_fullStr |
Therapeutic Effect of Schistosoma japonicum Cystatin on Atherosclerotic Renal Damage |
| title_full_unstemmed |
Therapeutic Effect of Schistosoma japonicum Cystatin on Atherosclerotic Renal Damage |
| title_sort |
therapeutic effect of schistosoma japonicum cystatin on atherosclerotic renal damage |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/6a31636123e34b7785334ad873a4b560 |
| work_keys_str_mv |
AT huijuanyang therapeuticeffectofschistosomajaponicumcystatinonatheroscleroticrenaldamage AT huijuanyang therapeuticeffectofschistosomajaponicumcystatinonatheroscleroticrenaldamage AT hongqili therapeuticeffectofschistosomajaponicumcystatinonatheroscleroticrenaldamage AT weidongchen therapeuticeffectofschistosomajaponicumcystatinonatheroscleroticrenaldamage AT zhijiemei therapeuticeffectofschistosomajaponicumcystatinonatheroscleroticrenaldamage AT yuanyuan therapeuticeffectofschistosomajaponicumcystatinonatheroscleroticrenaldamage AT yuanyuan therapeuticeffectofschistosomajaponicumcystatinonatheroscleroticrenaldamage AT xiaoliwang therapeuticeffectofschistosomajaponicumcystatinonatheroscleroticrenaldamage AT xiaoliwang therapeuticeffectofschistosomajaponicumcystatinonatheroscleroticrenaldamage AT liangchu therapeuticeffectofschistosomajaponicumcystatinonatheroscleroticrenaldamage AT yuxu therapeuticeffectofschistosomajaponicumcystatinonatheroscleroticrenaldamage AT yuxu therapeuticeffectofschistosomajaponicumcystatinonatheroscleroticrenaldamage AT yansun therapeuticeffectofschistosomajaponicumcystatinonatheroscleroticrenaldamage AT yansun therapeuticeffectofschistosomajaponicumcystatinonatheroscleroticrenaldamage AT dingruli therapeuticeffectofschistosomajaponicumcystatinonatheroscleroticrenaldamage AT dingruli therapeuticeffectofschistosomajaponicumcystatinonatheroscleroticrenaldamage AT hongyugao therapeuticeffectofschistosomajaponicumcystatinonatheroscleroticrenaldamage AT hongyugao therapeuticeffectofschistosomajaponicumcystatinonatheroscleroticrenaldamage AT binzhan therapeuticeffectofschistosomajaponicumcystatinonatheroscleroticrenaldamage AT huihuili therapeuticeffectofschistosomajaponicumcystatinonatheroscleroticrenaldamage AT huihuili therapeuticeffectofschistosomajaponicumcystatinonatheroscleroticrenaldamage AT xiaodiyang therapeuticeffectofschistosomajaponicumcystatinonatheroscleroticrenaldamage AT xiaodiyang therapeuticeffectofschistosomajaponicumcystatinonatheroscleroticrenaldamage |
| _version_ |
1718405963975753728 |