Utilization of rare codon-rich markers for screening amino acid overproducers

Current toxic analogues-based amino acid overproducer screening method cannot provide accuracy, sensitivity and high throughput simultaneously. Here, the authors use rare codon rich marker for the selection of overproducers of multiple amino acids from random mutation libraries of E. coli and C. glu...

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Autores principales: Bo Zheng, Xiaoyan Ma, Ning Wang, Tingting Ding, Liwei Guo, Xiaorong Zhang, Yu Yang, Chun Li, Yi-Xin Huo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/6a375f7309ef48ea9131810368d1e595
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spelling oai:doaj.org-article:6a375f7309ef48ea9131810368d1e5952021-12-02T14:39:07ZUtilization of rare codon-rich markers for screening amino acid overproducers10.1038/s41467-018-05830-02041-1723https://doaj.org/article/6a375f7309ef48ea9131810368d1e5952018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05830-0https://doaj.org/toc/2041-1723Current toxic analogues-based amino acid overproducer screening method cannot provide accuracy, sensitivity and high throughput simultaneously. Here, the authors use rare codon rich marker for the selection of overproducers of multiple amino acids from random mutation libraries of E. coli and C. glutamicum.Bo ZhengXiaoyan MaNing WangTingting DingLiwei GuoXiaorong ZhangYu YangChun LiYi-Xin HuoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Bo Zheng
Xiaoyan Ma
Ning Wang
Tingting Ding
Liwei Guo
Xiaorong Zhang
Yu Yang
Chun Li
Yi-Xin Huo
Utilization of rare codon-rich markers for screening amino acid overproducers
description Current toxic analogues-based amino acid overproducer screening method cannot provide accuracy, sensitivity and high throughput simultaneously. Here, the authors use rare codon rich marker for the selection of overproducers of multiple amino acids from random mutation libraries of E. coli and C. glutamicum.
format article
author Bo Zheng
Xiaoyan Ma
Ning Wang
Tingting Ding
Liwei Guo
Xiaorong Zhang
Yu Yang
Chun Li
Yi-Xin Huo
author_facet Bo Zheng
Xiaoyan Ma
Ning Wang
Tingting Ding
Liwei Guo
Xiaorong Zhang
Yu Yang
Chun Li
Yi-Xin Huo
author_sort Bo Zheng
title Utilization of rare codon-rich markers for screening amino acid overproducers
title_short Utilization of rare codon-rich markers for screening amino acid overproducers
title_full Utilization of rare codon-rich markers for screening amino acid overproducers
title_fullStr Utilization of rare codon-rich markers for screening amino acid overproducers
title_full_unstemmed Utilization of rare codon-rich markers for screening amino acid overproducers
title_sort utilization of rare codon-rich markers for screening amino acid overproducers
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/6a375f7309ef48ea9131810368d1e595
work_keys_str_mv AT bozheng utilizationofrarecodonrichmarkersforscreeningaminoacidoverproducers
AT xiaoyanma utilizationofrarecodonrichmarkersforscreeningaminoacidoverproducers
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AT tingtingding utilizationofrarecodonrichmarkersforscreeningaminoacidoverproducers
AT liweiguo utilizationofrarecodonrichmarkersforscreeningaminoacidoverproducers
AT xiaorongzhang utilizationofrarecodonrichmarkersforscreeningaminoacidoverproducers
AT yuyang utilizationofrarecodonrichmarkersforscreeningaminoacidoverproducers
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AT yixinhuo utilizationofrarecodonrichmarkersforscreeningaminoacidoverproducers
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