Lipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 2

Neurofibromin 2 (NF2) is a tumour suppressor that inhibits cell growth. Here the authors combine functional, biochemical, and structural studies and show that lipid-bound NF2 adopts an open conformation and that NF2 lipid binding is required for inhibition of cell proliferation.

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Autores principales:	Krishna Chinthalapudi, Vinay Mandati, Jie Zheng, Andrew J. Sharff, Gerard Bricogne, Patrick R. Griffin, Joseph Kissil, Tina Izard
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6a39c45334a64f2096f37fa863eb2504
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spelling	oai:doaj.org-article:6a39c45334a64f2096f37fa863eb25042021-12-02T14:39:06ZLipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 210.1038/s41467-018-03648-42041-1723https://doaj.org/article/6a39c45334a64f2096f37fa863eb25042018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03648-4https://doaj.org/toc/2041-1723Neurofibromin 2 (NF2) is a tumour suppressor that inhibits cell growth. Here the authors combine functional, biochemical, and structural studies and show that lipid-bound NF2 adopts an open conformation and that NF2 lipid binding is required for inhibition of cell proliferation.Krishna ChinthalapudiVinay MandatiJie ZhengAndrew J. SharffGerard BricognePatrick R. GriffinJoseph KissilTina IzardNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Krishna Chinthalapudi Vinay Mandati Jie Zheng Andrew J. Sharff Gerard Bricogne Patrick R. Griffin Joseph Kissil Tina Izard Lipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 2
description	Neurofibromin 2 (NF2) is a tumour suppressor that inhibits cell growth. Here the authors combine functional, biochemical, and structural studies and show that lipid-bound NF2 adopts an open conformation and that NF2 lipid binding is required for inhibition of cell proliferation.
format	article
author	Krishna Chinthalapudi Vinay Mandati Jie Zheng Andrew J. Sharff Gerard Bricogne Patrick R. Griffin Joseph Kissil Tina Izard
author_facet	Krishna Chinthalapudi Vinay Mandati Jie Zheng Andrew J. Sharff Gerard Bricogne Patrick R. Griffin Joseph Kissil Tina Izard
author_sort	Krishna Chinthalapudi
title	Lipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 2
title_short	Lipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 2
title_full	Lipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 2
title_fullStr	Lipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 2
title_full_unstemmed	Lipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 2
title_sort	lipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 2
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/6a39c45334a64f2096f37fa863eb2504
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Lipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 2

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