High-salt intake negatively regulates fat deposition in mouse

Abstract High-salt (HS) intake contributes to hypertension and cardiopathy, but the effect of HS on fat deposition is controversial. Feed intake, fat mass, the percentage of abdominal fat, heat production, rate of oxygen consumption and the respiratory exchange ratio of mice on a HS diet were signif...

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Autores principales:	Huanxian Cui, Shuyan Yang, Maiqing Zheng, Ranran Liu, Guiping Zhao, Jie Wen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6a3c0029093647d7a6dba663bfccc581
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spelling	oai:doaj.org-article:6a3c0029093647d7a6dba663bfccc5812021-12-02T16:07:06ZHigh-salt intake negatively regulates fat deposition in mouse10.1038/s41598-017-01560-32045-2322https://doaj.org/article/6a3c0029093647d7a6dba663bfccc5812017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01560-3https://doaj.org/toc/2045-2322Abstract High-salt (HS) intake contributes to hypertension and cardiopathy, but the effect of HS on fat deposition is controversial. Feed intake, fat mass, the percentage of abdominal fat, heat production, rate of oxygen consumption and the respiratory exchange ratio of mice on a HS diet were significantly decreased (P < 0.01 or 0.05) compared with mice on a normal-salt (NS) diet. An in vitro experiment with differentiating pre-adipocytes showed reduced fat deposition in the presence of high concentrations of NaCl (>0.05 M). Abdominal fat mRNA profiles and protein measurements showed that 5 known genes involved in lipolysis were up-regulated significantly and 9 genes related to lipogenesis were down-regulated in HS mice. Abundant genes and some proteins (ATP2a1, AGT, and ANGPTL4) related to calcium ion metabolism or the renin-angiotensin system (RAS) were differentially expressed between HS and NS mice. Of special interest, CREB1 phosphorylation (S133 and S142), a key factor involved in calcium signaling and other pathways, was up-regulated in HS mice. By IPA analysis, a network mediated by calcium was established providing the molecular mechanisms underlying the negative effect of HS on fat deposition.Huanxian CuiShuyan YangMaiqing ZhengRanran LiuGuiping ZhaoJie WenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Huanxian Cui Shuyan Yang Maiqing Zheng Ranran Liu Guiping Zhao Jie Wen High-salt intake negatively regulates fat deposition in mouse
description	Abstract High-salt (HS) intake contributes to hypertension and cardiopathy, but the effect of HS on fat deposition is controversial. Feed intake, fat mass, the percentage of abdominal fat, heat production, rate of oxygen consumption and the respiratory exchange ratio of mice on a HS diet were significantly decreased (P < 0.01 or 0.05) compared with mice on a normal-salt (NS) diet. An in vitro experiment with differentiating pre-adipocytes showed reduced fat deposition in the presence of high concentrations of NaCl (>0.05 M). Abdominal fat mRNA profiles and protein measurements showed that 5 known genes involved in lipolysis were up-regulated significantly and 9 genes related to lipogenesis were down-regulated in HS mice. Abundant genes and some proteins (ATP2a1, AGT, and ANGPTL4) related to calcium ion metabolism or the renin-angiotensin system (RAS) were differentially expressed between HS and NS mice. Of special interest, CREB1 phosphorylation (S133 and S142), a key factor involved in calcium signaling and other pathways, was up-regulated in HS mice. By IPA analysis, a network mediated by calcium was established providing the molecular mechanisms underlying the negative effect of HS on fat deposition.
format	article
author	Huanxian Cui Shuyan Yang Maiqing Zheng Ranran Liu Guiping Zhao Jie Wen
author_facet	Huanxian Cui Shuyan Yang Maiqing Zheng Ranran Liu Guiping Zhao Jie Wen
author_sort	Huanxian Cui
title	High-salt intake negatively regulates fat deposition in mouse
title_short	High-salt intake negatively regulates fat deposition in mouse
title_full	High-salt intake negatively regulates fat deposition in mouse
title_fullStr	High-salt intake negatively regulates fat deposition in mouse
title_full_unstemmed	High-salt intake negatively regulates fat deposition in mouse
title_sort	high-salt intake negatively regulates fat deposition in mouse
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6a3c0029093647d7a6dba663bfccc581
work_keys_str_mv	AT huanxiancui highsaltintakenegativelyregulatesfatdepositioninmouse AT shuyanyang highsaltintakenegativelyregulatesfatdepositioninmouse AT maiqingzheng highsaltintakenegativelyregulatesfatdepositioninmouse AT ranranliu highsaltintakenegativelyregulatesfatdepositioninmouse AT guipingzhao highsaltintakenegativelyregulatesfatdepositioninmouse AT jiewen highsaltintakenegativelyregulatesfatdepositioninmouse
_version_	1718384721415634944

High-salt intake negatively regulates fat deposition in mouse

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