FREQUENCY DISTRIBUTION OF INTRONIC POLYMORPHISMS OF IL1-raVNTR AND IL-4VNTR IN RHEUMATIC MITRAL VALVE DISEASE IN CAUCASIAN POPULATION OF SIBERIA

A search for associations between allelic variations of immune response genes, and mitral stenosis associated with rheumatic heart disease, represents an important task when studying the pathogenesis of cardiovascular disorders among inhabitants of large industrial regions in Western Siberia. Among...

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Autores principales:	A. V. Ponasenko, A. S. Golovkin, A. V. Shabaldin, A. V. Tsepokina
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2015
Materias:	rheumatic disease of heart mitral stenosis genes il-1ra il-4 variable nucleotide tandem repeats Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/6a3c0d22047a4933bcc596494cf6ed1e
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spelling	oai:doaj.org-article:6a3c0d22047a4933bcc596494cf6ed1e2021-11-18T08:03:44ZFREQUENCY DISTRIBUTION OF INTRONIC POLYMORPHISMS OF IL1-raVNTR AND IL-4VNTR IN RHEUMATIC MITRAL VALVE DISEASE IN CAUCASIAN POPULATION OF SIBERIA1563-06252313-741X10.15789/1563-0625-2015-2-151-158https://doaj.org/article/6a3c0d22047a4933bcc596494cf6ed1e2015-04-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/833https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XA search for associations between allelic variations of immune response genes, and mitral stenosis associated with rheumatic heart disease, represents an important task when studying the pathogenesis of cardiovascular disorders among inhabitants of large industrial regions in Western Siberia. Among multiple polymorphisms of interleukin-encoding genes, a particular attention should be paid to association studies of some intronic polymorphisms with variable numbers of tandem repeats (VNTR). In this respect, genotyping of interleukin 1 receptor antagonist genes (IL-1ra86bp VNTR) and interleukin 4 (IL-470bp VNTR) has shown positive associations between the intron 2 IL-1ra3R/3R microsatellite polymorphism, intron 3 IL-42R/2R variant, and the risk of mitral stenosis development in patients with rheumatic heart disease (OR = 12.71; p = 0.0001).A. V. PonasenkoA. S. GolovkinA. V. ShabaldinA. V. TsepokinaSPb RAACIarticlerheumatic disease of heartmitral stenosisgenesil-1rail-4variable nucleotide tandem repeatsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 17, Iss 2, Pp 151-158 (2015)
institution	DOAJ
collection	DOAJ
language	RU
topic	rheumatic disease of heart mitral stenosis genes il-1ra il-4 variable nucleotide tandem repeats Immunologic diseases. Allergy RC581-607
spellingShingle	rheumatic disease of heart mitral stenosis genes il-1ra il-4 variable nucleotide tandem repeats Immunologic diseases. Allergy RC581-607 A. V. Ponasenko A. S. Golovkin A. V. Shabaldin A. V. Tsepokina FREQUENCY DISTRIBUTION OF INTRONIC POLYMORPHISMS OF IL1-raVNTR AND IL-4VNTR IN RHEUMATIC MITRAL VALVE DISEASE IN CAUCASIAN POPULATION OF SIBERIA
description	A search for associations between allelic variations of immune response genes, and mitral stenosis associated with rheumatic heart disease, represents an important task when studying the pathogenesis of cardiovascular disorders among inhabitants of large industrial regions in Western Siberia. Among multiple polymorphisms of interleukin-encoding genes, a particular attention should be paid to association studies of some intronic polymorphisms with variable numbers of tandem repeats (VNTR). In this respect, genotyping of interleukin 1 receptor antagonist genes (IL-1ra86bp VNTR) and interleukin 4 (IL-470bp VNTR) has shown positive associations between the intron 2 IL-1ra3R/3R microsatellite polymorphism, intron 3 IL-42R/2R variant, and the risk of mitral stenosis development in patients with rheumatic heart disease (OR = 12.71; p = 0.0001).
format	article
author	A. V. Ponasenko A. S. Golovkin A. V. Shabaldin A. V. Tsepokina
author_facet	A. V. Ponasenko A. S. Golovkin A. V. Shabaldin A. V. Tsepokina
author_sort	A. V. Ponasenko
title	FREQUENCY DISTRIBUTION OF INTRONIC POLYMORPHISMS OF IL1-raVNTR AND IL-4VNTR IN RHEUMATIC MITRAL VALVE DISEASE IN CAUCASIAN POPULATION OF SIBERIA
title_short	FREQUENCY DISTRIBUTION OF INTRONIC POLYMORPHISMS OF IL1-raVNTR AND IL-4VNTR IN RHEUMATIC MITRAL VALVE DISEASE IN CAUCASIAN POPULATION OF SIBERIA
title_full	FREQUENCY DISTRIBUTION OF INTRONIC POLYMORPHISMS OF IL1-raVNTR AND IL-4VNTR IN RHEUMATIC MITRAL VALVE DISEASE IN CAUCASIAN POPULATION OF SIBERIA
title_fullStr	FREQUENCY DISTRIBUTION OF INTRONIC POLYMORPHISMS OF IL1-raVNTR AND IL-4VNTR IN RHEUMATIC MITRAL VALVE DISEASE IN CAUCASIAN POPULATION OF SIBERIA
title_full_unstemmed	FREQUENCY DISTRIBUTION OF INTRONIC POLYMORPHISMS OF IL1-raVNTR AND IL-4VNTR IN RHEUMATIC MITRAL VALVE DISEASE IN CAUCASIAN POPULATION OF SIBERIA
title_sort	frequency distribution of intronic polymorphisms of il1-ravntr and il-4vntr in rheumatic mitral valve disease in caucasian population of siberia
publisher	SPb RAACI
publishDate	2015
url	https://doaj.org/article/6a3c0d22047a4933bcc596494cf6ed1e
work_keys_str_mv	AT avponasenko frequencydistributionofintronicpolymorphismsofil1ravntrandil4vntrinrheumaticmitralvalvediseaseincaucasianpopulationofsiberia AT asgolovkin frequencydistributionofintronicpolymorphismsofil1ravntrandil4vntrinrheumaticmitralvalvediseaseincaucasianpopulationofsiberia AT avshabaldin frequencydistributionofintronicpolymorphismsofil1ravntrandil4vntrinrheumaticmitralvalvediseaseincaucasianpopulationofsiberia AT avtsepokina frequencydistributionofintronicpolymorphismsofil1ravntrandil4vntrinrheumaticmitralvalvediseaseincaucasianpopulationofsiberia
_version_	1718422422729785344

FREQUENCY DISTRIBUTION OF INTRONIC POLYMORPHISMS OF IL1-raVNTR AND IL-4VNTR IN RHEUMATIC MITRAL VALVE DISEASE IN CAUCASIAN POPULATION OF SIBERIA

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