Effect of prostaglandin analogues on anterior scleral thickness and corneal thickness in patients with primary open-angle glaucoma

Abstract Prostaglandin (PG) analogues are usually prescribed as a first-line therapy in patients with glaucoma because of its once-daily dosing benefit and effective intraocular pressure (IOP) reduction. However, the mechanism of PG analogues is not completely understood. In this study, we investiga...

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Autores principales:	Ji-Hye Park, Chungkwon Yoo, Hyun Woo Chung, Yong Yeon Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6a3d5f284a7a4d8ca7d71bae717c817a
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spelling	oai:doaj.org-article:6a3d5f284a7a4d8ca7d71bae717c817a2021-12-02T16:53:19ZEffect of prostaglandin analogues on anterior scleral thickness and corneal thickness in patients with primary open-angle glaucoma10.1038/s41598-021-90696-42045-2322https://doaj.org/article/6a3d5f284a7a4d8ca7d71bae717c817a2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90696-4https://doaj.org/toc/2045-2322Abstract Prostaglandin (PG) analogues are usually prescribed as a first-line therapy in patients with glaucoma because of its once-daily dosing benefit and effective intraocular pressure (IOP) reduction. However, the mechanism of PG analogues is not completely understood. In this study, we investigated the effect of PG analogues on the anterior scleral thickness (AST) in treatment-naïve eyes with primary open-angle glaucoma using anterior segment optical coherence tomography. The AST was measured at the location of the scleral spur, 1000 μm, and 2000 μm posterior to the scleral spur and was compared before and after using the medications for 3 months and 1 year. Among 54 patients enrolled in this study, 31 patients used prostaglandin analogues and 23 patients used dorzolamide/timolol fixed combination (DTFC) drugs. There was no significant difference in untreated IOP, glaucoma severity, and baseline AST values between the two groups. While there was no significant changes in AST after using the DTFC drugs, the AST at all 3 locations showed a significant reduction in both the nasal and temporal sectors after using PG analogues for 1 year (all, P < 0.05). These findings suggest that the AST reduction after using PG analogues might be related with the increased uveoscleral outflow.Ji-Hye ParkChungkwon YooHyun Woo ChungYong Yeon KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ji-Hye Park Chungkwon Yoo Hyun Woo Chung Yong Yeon Kim Effect of prostaglandin analogues on anterior scleral thickness and corneal thickness in patients with primary open-angle glaucoma
description	Abstract Prostaglandin (PG) analogues are usually prescribed as a first-line therapy in patients with glaucoma because of its once-daily dosing benefit and effective intraocular pressure (IOP) reduction. However, the mechanism of PG analogues is not completely understood. In this study, we investigated the effect of PG analogues on the anterior scleral thickness (AST) in treatment-naïve eyes with primary open-angle glaucoma using anterior segment optical coherence tomography. The AST was measured at the location of the scleral spur, 1000 μm, and 2000 μm posterior to the scleral spur and was compared before and after using the medications for 3 months and 1 year. Among 54 patients enrolled in this study, 31 patients used prostaglandin analogues and 23 patients used dorzolamide/timolol fixed combination (DTFC) drugs. There was no significant difference in untreated IOP, glaucoma severity, and baseline AST values between the two groups. While there was no significant changes in AST after using the DTFC drugs, the AST at all 3 locations showed a significant reduction in both the nasal and temporal sectors after using PG analogues for 1 year (all, P < 0.05). These findings suggest that the AST reduction after using PG analogues might be related with the increased uveoscleral outflow.
format	article
author	Ji-Hye Park Chungkwon Yoo Hyun Woo Chung Yong Yeon Kim
author_facet	Ji-Hye Park Chungkwon Yoo Hyun Woo Chung Yong Yeon Kim
author_sort	Ji-Hye Park
title	Effect of prostaglandin analogues on anterior scleral thickness and corneal thickness in patients with primary open-angle glaucoma
title_short	Effect of prostaglandin analogues on anterior scleral thickness and corneal thickness in patients with primary open-angle glaucoma
title_full	Effect of prostaglandin analogues on anterior scleral thickness and corneal thickness in patients with primary open-angle glaucoma
title_fullStr	Effect of prostaglandin analogues on anterior scleral thickness and corneal thickness in patients with primary open-angle glaucoma
title_full_unstemmed	Effect of prostaglandin analogues on anterior scleral thickness and corneal thickness in patients with primary open-angle glaucoma
title_sort	effect of prostaglandin analogues on anterior scleral thickness and corneal thickness in patients with primary open-angle glaucoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6a3d5f284a7a4d8ca7d71bae717c817a
work_keys_str_mv	AT jihyepark effectofprostaglandinanaloguesonanteriorscleralthicknessandcornealthicknessinpatientswithprimaryopenangleglaucoma AT chungkwonyoo effectofprostaglandinanaloguesonanteriorscleralthicknessandcornealthicknessinpatientswithprimaryopenangleglaucoma AT hyunwoochung effectofprostaglandinanaloguesonanteriorscleralthicknessandcornealthicknessinpatientswithprimaryopenangleglaucoma AT yongyeonkim effectofprostaglandinanaloguesonanteriorscleralthicknessandcornealthicknessinpatientswithprimaryopenangleglaucoma
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Effect of prostaglandin analogues on anterior scleral thickness and corneal thickness in patients with primary open-angle glaucoma

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