Dynamic organelle distribution initiates actin-based spindle migration in mouse oocytes

Mammalian oocytes divide asymmetrically during meiotic maturation. Here, the authors show that spindle movement away from oocyte center depends on actin filaments nucleated from the spindle periphery pushing against surrounding mitochondria, which polarizes spontaneously to produce directional spind...

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Autores principales: Xing Duan, Yizeng Li, Kexi Yi, Fengli Guo, HaiYang Wang, Pei-Hsun Wu, Jing Yang, Devin B. Mair, Edwin Angelo Morales, Petr Kalab, Denis Wirtz, Sean X. Sun, Rong Li
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Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/6a3dff5293d84b4c8302fd9120483af3
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spelling oai:doaj.org-article:6a3dff5293d84b4c8302fd9120483af32021-12-02T15:33:31ZDynamic organelle distribution initiates actin-based spindle migration in mouse oocytes10.1038/s41467-019-14068-32041-1723https://doaj.org/article/6a3dff5293d84b4c8302fd9120483af32020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14068-3https://doaj.org/toc/2041-1723Mammalian oocytes divide asymmetrically during meiotic maturation. Here, the authors show that spindle movement away from oocyte center depends on actin filaments nucleated from the spindle periphery pushing against surrounding mitochondria, which polarizes spontaneously to produce directional spindle motion.Xing DuanYizeng LiKexi YiFengli GuoHaiYang WangPei-Hsun WuJing YangDevin B. MairEdwin Angelo MoralesPetr KalabDenis WirtzSean X. SunRong LiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xing Duan
Yizeng Li
Kexi Yi
Fengli Guo
HaiYang Wang
Pei-Hsun Wu
Jing Yang
Devin B. Mair
Edwin Angelo Morales
Petr Kalab
Denis Wirtz
Sean X. Sun
Rong Li
Dynamic organelle distribution initiates actin-based spindle migration in mouse oocytes
description Mammalian oocytes divide asymmetrically during meiotic maturation. Here, the authors show that spindle movement away from oocyte center depends on actin filaments nucleated from the spindle periphery pushing against surrounding mitochondria, which polarizes spontaneously to produce directional spindle motion.
format article
author Xing Duan
Yizeng Li
Kexi Yi
Fengli Guo
HaiYang Wang
Pei-Hsun Wu
Jing Yang
Devin B. Mair
Edwin Angelo Morales
Petr Kalab
Denis Wirtz
Sean X. Sun
Rong Li
author_facet Xing Duan
Yizeng Li
Kexi Yi
Fengli Guo
HaiYang Wang
Pei-Hsun Wu
Jing Yang
Devin B. Mair
Edwin Angelo Morales
Petr Kalab
Denis Wirtz
Sean X. Sun
Rong Li
author_sort Xing Duan
title Dynamic organelle distribution initiates actin-based spindle migration in mouse oocytes
title_short Dynamic organelle distribution initiates actin-based spindle migration in mouse oocytes
title_full Dynamic organelle distribution initiates actin-based spindle migration in mouse oocytes
title_fullStr Dynamic organelle distribution initiates actin-based spindle migration in mouse oocytes
title_full_unstemmed Dynamic organelle distribution initiates actin-based spindle migration in mouse oocytes
title_sort dynamic organelle distribution initiates actin-based spindle migration in mouse oocytes
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/6a3dff5293d84b4c8302fd9120483af3
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