Dynamic organelle distribution initiates actin-based spindle migration in mouse oocytes
Mammalian oocytes divide asymmetrically during meiotic maturation. Here, the authors show that spindle movement away from oocyte center depends on actin filaments nucleated from the spindle periphery pushing against surrounding mitochondria, which polarizes spontaneously to produce directional spind...
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Nature Portfolio
2020
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oai:doaj.org-article:6a3dff5293d84b4c8302fd9120483af32021-12-02T15:33:31ZDynamic organelle distribution initiates actin-based spindle migration in mouse oocytes10.1038/s41467-019-14068-32041-1723https://doaj.org/article/6a3dff5293d84b4c8302fd9120483af32020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14068-3https://doaj.org/toc/2041-1723Mammalian oocytes divide asymmetrically during meiotic maturation. Here, the authors show that spindle movement away from oocyte center depends on actin filaments nucleated from the spindle periphery pushing against surrounding mitochondria, which polarizes spontaneously to produce directional spindle motion.Xing DuanYizeng LiKexi YiFengli GuoHaiYang WangPei-Hsun WuJing YangDevin B. MairEdwin Angelo MoralesPetr KalabDenis WirtzSean X. SunRong LiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020) |
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Science Q |
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Science Q Xing Duan Yizeng Li Kexi Yi Fengli Guo HaiYang Wang Pei-Hsun Wu Jing Yang Devin B. Mair Edwin Angelo Morales Petr Kalab Denis Wirtz Sean X. Sun Rong Li Dynamic organelle distribution initiates actin-based spindle migration in mouse oocytes |
description |
Mammalian oocytes divide asymmetrically during meiotic maturation. Here, the authors show that spindle movement away from oocyte center depends on actin filaments nucleated from the spindle periphery pushing against surrounding mitochondria, which polarizes spontaneously to produce directional spindle motion. |
format |
article |
author |
Xing Duan Yizeng Li Kexi Yi Fengli Guo HaiYang Wang Pei-Hsun Wu Jing Yang Devin B. Mair Edwin Angelo Morales Petr Kalab Denis Wirtz Sean X. Sun Rong Li |
author_facet |
Xing Duan Yizeng Li Kexi Yi Fengli Guo HaiYang Wang Pei-Hsun Wu Jing Yang Devin B. Mair Edwin Angelo Morales Petr Kalab Denis Wirtz Sean X. Sun Rong Li |
author_sort |
Xing Duan |
title |
Dynamic organelle distribution initiates actin-based spindle migration in mouse oocytes |
title_short |
Dynamic organelle distribution initiates actin-based spindle migration in mouse oocytes |
title_full |
Dynamic organelle distribution initiates actin-based spindle migration in mouse oocytes |
title_fullStr |
Dynamic organelle distribution initiates actin-based spindle migration in mouse oocytes |
title_full_unstemmed |
Dynamic organelle distribution initiates actin-based spindle migration in mouse oocytes |
title_sort |
dynamic organelle distribution initiates actin-based spindle migration in mouse oocytes |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/6a3dff5293d84b4c8302fd9120483af3 |
work_keys_str_mv |
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1718387087023013888 |