Dynamic organelle distribution initiates actin-based spindle migration in mouse oocytes

Mammalian oocytes divide asymmetrically during meiotic maturation. Here, the authors show that spindle movement away from oocyte center depends on actin filaments nucleated from the spindle periphery pushing against surrounding mitochondria, which polarizes spontaneously to produce directional spind...

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Autores principales: Xing Duan, Yizeng Li, Kexi Yi, Fengli Guo, HaiYang Wang, Pei-Hsun Wu, Jing Yang, Devin B. Mair, Edwin Angelo Morales, Petr Kalab, Denis Wirtz, Sean X. Sun, Rong Li
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/6a3dff5293d84b4c8302fd9120483af3
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