Ancestral perinatal obesogen exposure results in a transgenerational thrifty phenotype in mice

Early life exposure to endocrine disrupting chemicals has been linked to increased adiposity during adulthood. Here Chamorro-García et al. show that ancestral exposure to the obesogen tributyltin causes obesity in untreated F4 generation male descendants by inducing heritable changes in genome archi...

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Autores principales:	Raquel Chamorro-Garcia, Carlos Diaz-Castillo, Bassem M. Shoucri, Heidi Käch, Ron Leavitt, Toshi Shioda, Bruce Blumberg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6a3e216884f74baab7cacd84d2bea3cf
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spelling	oai:doaj.org-article:6a3e216884f74baab7cacd84d2bea3cf2021-12-02T14:42:43ZAncestral perinatal obesogen exposure results in a transgenerational thrifty phenotype in mice10.1038/s41467-017-01944-z2041-1723https://doaj.org/article/6a3e216884f74baab7cacd84d2bea3cf2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01944-zhttps://doaj.org/toc/2041-1723Early life exposure to endocrine disrupting chemicals has been linked to increased adiposity during adulthood. Here Chamorro-García et al. show that ancestral exposure to the obesogen tributyltin causes obesity in untreated F4 generation male descendants by inducing heritable changes in genome architecture that promote a thrifty phenotype.Raquel Chamorro-GarciaCarlos Diaz-CastilloBassem M. ShoucriHeidi KächRon LeavittToshi ShiodaBruce BlumbergNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Raquel Chamorro-Garcia Carlos Diaz-Castillo Bassem M. Shoucri Heidi Käch Ron Leavitt Toshi Shioda Bruce Blumberg Ancestral perinatal obesogen exposure results in a transgenerational thrifty phenotype in mice
description	Early life exposure to endocrine disrupting chemicals has been linked to increased adiposity during adulthood. Here Chamorro-García et al. show that ancestral exposure to the obesogen tributyltin causes obesity in untreated F4 generation male descendants by inducing heritable changes in genome architecture that promote a thrifty phenotype.
format	article
author	Raquel Chamorro-Garcia Carlos Diaz-Castillo Bassem M. Shoucri Heidi Käch Ron Leavitt Toshi Shioda Bruce Blumberg
author_facet	Raquel Chamorro-Garcia Carlos Diaz-Castillo Bassem M. Shoucri Heidi Käch Ron Leavitt Toshi Shioda Bruce Blumberg
author_sort	Raquel Chamorro-Garcia
title	Ancestral perinatal obesogen exposure results in a transgenerational thrifty phenotype in mice
title_short	Ancestral perinatal obesogen exposure results in a transgenerational thrifty phenotype in mice
title_full	Ancestral perinatal obesogen exposure results in a transgenerational thrifty phenotype in mice
title_fullStr	Ancestral perinatal obesogen exposure results in a transgenerational thrifty phenotype in mice
title_full_unstemmed	Ancestral perinatal obesogen exposure results in a transgenerational thrifty phenotype in mice
title_sort	ancestral perinatal obesogen exposure results in a transgenerational thrifty phenotype in mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6a3e216884f74baab7cacd84d2bea3cf
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Ancestral perinatal obesogen exposure results in a transgenerational thrifty phenotype in mice

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