Increased Frequency of Circulating Classical Monocytes in Patients with Rosacea

Cuie Gao,1 Lan Ge,1 Dewei Chen,2 Mengjie Zhang,2 Li Zhao,2 Wenying Liu,1 Shuguang Chen,1 Juan Wang,1 Cunjian Zhou,1 Xingwang Zhao,1 Shifei Li,1 Zhiqiang Song,1 Jian Li1 1Department of Dermatology, Southwest Hospital, Army Medical University, Chongqing, 400038, People’s Republic of China; 2Department...

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Autores principales:	Gao C, Ge L, Chen D, Zhang M, Zhao L, Liu W, Chen S, Wang J, Zhou C, Zhao X, Li S, Song Z, Li J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	monocytes classical monocytes ccr2 rosacea Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/6a3f10bce4e048fa82418c182652e36e
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spelling	oai:doaj.org-article:6a3f10bce4e048fa82418c182652e36e2021-11-09T18:40:35ZIncreased Frequency of Circulating Classical Monocytes in Patients with Rosacea1178-7015https://doaj.org/article/6a3f10bce4e048fa82418c182652e36e2021-11-01T00:00:00Zhttps://www.dovepress.com/increased-frequency-of-circulating-classical-monocytes-in-patients-wit-peer-reviewed-fulltext-article-CCIDhttps://doaj.org/toc/1178-7015Cuie Gao,1 Lan Ge,1 Dewei Chen,2 Mengjie Zhang,2 Li Zhao,2 Wenying Liu,1 Shuguang Chen,1 Juan Wang,1 Cunjian Zhou,1 Xingwang Zhao,1 Shifei Li,1 Zhiqiang Song,1 Jian Li1 1Department of Dermatology, Southwest Hospital, Army Medical University, Chongqing, 400038, People’s Republic of China; 2Department of Pathophysiology, Army Medical University, Chongqing, 400038, People’s Republic of ChinaCorrespondence: Jian Li; Zhiqiang SongDepartment of Dermatology, Southwest Hospital, Army Medical University, Chongqing, 400038, People’s Republic of ChinaTel +86 23 68754290Fax +86 23 68755290Email leejian860@126.com; drsongzq@hotmail.comPurpose: Monocyte subsets, including classical, intermediate and non-classical monocytes, are involved in the pathogenesis of inflammatory or autoimmune diseases. The pathogenic role of monocytes in the peripheral blood mononuclear cells (PBMCs) of patients with rosacea remains unclear. This study aimed to assess frequencies of monocyte subsets in PBMCs from rosacea patients before and after clinical treatment.Patients and Methods: We applied flow cytometry to examine frequencies of monocyte subsets in 116 patients with rosacea, while patients with 26 systemic lupus erythematosus (SLE), 28 acne and 42 normal healthy subjects without skin problems (HC) were recruited as controls. Expression of C–C chemokine receptor 2 (CCR2) on monocytes and plasma levels of CC-chemokine ligand 2 (CCL2), high mobility group box-1 (HMGB-1), interleukin-1 beta (IL-1β) and tumor necrosis factor alpha (TNF-α) were measured in HC and rosacea patients before and after treatment.Results: The frequency of classical monocytes, but not intermediate or non-classical monocytes, was higher in rosacea as compared with HC, which decreased after treatment. Frequencies of monocyte subsets showed no gender difference, while increased with age in patients but not in HC. Frequencies of classical monocytes in patients with erythematotelangiectatic rosacea (ETR) and ETR-papulopustular rosacea (PPR) overlap were significantly higher than HC or patients with only PPR or phymatous rosacea (PhR). There was a significant higher expression of CCR2 in classical monocytes, with higher plasma levels of CCL2, HMGB-1, IL-1β and TNF-α in patients than in HC, which all significantly decreased after treatment.Conclusion: Our data indicated a possible association between abnormal classical monocytes frequencies and rosacea.Keywords: monocytes, classical monocytes, CCR2, rosaceaGao CGe LChen DZhang MZhao LLiu WChen SWang JZhou CZhao XLi SSong ZLi JDove Medical Pressarticlemonocytesclassical monocytesccr2rosaceaDermatologyRL1-803ENClinical, Cosmetic and Investigational Dermatology, Vol Volume 14, Pp 1629-1636 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	monocytes classical monocytes ccr2 rosacea Dermatology RL1-803
spellingShingle	monocytes classical monocytes ccr2 rosacea Dermatology RL1-803 Gao C Ge L Chen D Zhang M Zhao L Liu W Chen S Wang J Zhou C Zhao X Li S Song Z Li J Increased Frequency of Circulating Classical Monocytes in Patients with Rosacea
description	Cuie Gao,1 Lan Ge,1 Dewei Chen,2 Mengjie Zhang,2 Li Zhao,2 Wenying Liu,1 Shuguang Chen,1 Juan Wang,1 Cunjian Zhou,1 Xingwang Zhao,1 Shifei Li,1 Zhiqiang Song,1 Jian Li1 1Department of Dermatology, Southwest Hospital, Army Medical University, Chongqing, 400038, People’s Republic of China; 2Department of Pathophysiology, Army Medical University, Chongqing, 400038, People’s Republic of ChinaCorrespondence: Jian Li; Zhiqiang SongDepartment of Dermatology, Southwest Hospital, Army Medical University, Chongqing, 400038, People’s Republic of ChinaTel +86 23 68754290Fax +86 23 68755290Email leejian860@126.com; drsongzq@hotmail.comPurpose: Monocyte subsets, including classical, intermediate and non-classical monocytes, are involved in the pathogenesis of inflammatory or autoimmune diseases. The pathogenic role of monocytes in the peripheral blood mononuclear cells (PBMCs) of patients with rosacea remains unclear. This study aimed to assess frequencies of monocyte subsets in PBMCs from rosacea patients before and after clinical treatment.Patients and Methods: We applied flow cytometry to examine frequencies of monocyte subsets in 116 patients with rosacea, while patients with 26 systemic lupus erythematosus (SLE), 28 acne and 42 normal healthy subjects without skin problems (HC) were recruited as controls. Expression of C–C chemokine receptor 2 (CCR2) on monocytes and plasma levels of CC-chemokine ligand 2 (CCL2), high mobility group box-1 (HMGB-1), interleukin-1 beta (IL-1β) and tumor necrosis factor alpha (TNF-α) were measured in HC and rosacea patients before and after treatment.Results: The frequency of classical monocytes, but not intermediate or non-classical monocytes, was higher in rosacea as compared with HC, which decreased after treatment. Frequencies of monocyte subsets showed no gender difference, while increased with age in patients but not in HC. Frequencies of classical monocytes in patients with erythematotelangiectatic rosacea (ETR) and ETR-papulopustular rosacea (PPR) overlap were significantly higher than HC or patients with only PPR or phymatous rosacea (PhR). There was a significant higher expression of CCR2 in classical monocytes, with higher plasma levels of CCL2, HMGB-1, IL-1β and TNF-α in patients than in HC, which all significantly decreased after treatment.Conclusion: Our data indicated a possible association between abnormal classical monocytes frequencies and rosacea.Keywords: monocytes, classical monocytes, CCR2, rosacea
format	article
author	Gao C Ge L Chen D Zhang M Zhao L Liu W Chen S Wang J Zhou C Zhao X Li S Song Z Li J
author_facet	Gao C Ge L Chen D Zhang M Zhao L Liu W Chen S Wang J Zhou C Zhao X Li S Song Z Li J
author_sort	Gao C
title	Increased Frequency of Circulating Classical Monocytes in Patients with Rosacea
title_short	Increased Frequency of Circulating Classical Monocytes in Patients with Rosacea
title_full	Increased Frequency of Circulating Classical Monocytes in Patients with Rosacea
title_fullStr	Increased Frequency of Circulating Classical Monocytes in Patients with Rosacea
title_full_unstemmed	Increased Frequency of Circulating Classical Monocytes in Patients with Rosacea
title_sort	increased frequency of circulating classical monocytes in patients with rosacea
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/6a3f10bce4e048fa82418c182652e36e
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Increased Frequency of Circulating Classical Monocytes in Patients with Rosacea

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