Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer

The functional significance of T-cell infiltration in pancreatic ductal adenocarcinoma in relation to desmoplastic stroma is unclear. Here the authors develop a method to spatially resolve tumour stroma composition and find that spatial T-cell infiltration correlates with patient prognosis regardles...

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Autores principales:	Julienne L. Carstens, Pedro Correa de Sampaio, Dalu Yang, Souptik Barua, Huamin Wang, Arvind Rao, James P. Allison, Valerie S. LeBleu, Raghu Kalluri
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6a442765a1b54d688e2663f994aa8df6
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spelling	oai:doaj.org-article:6a442765a1b54d688e2663f994aa8df62021-12-02T17:06:13ZSpatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer10.1038/ncomms150952041-1723https://doaj.org/article/6a442765a1b54d688e2663f994aa8df62017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms15095https://doaj.org/toc/2041-1723The functional significance of T-cell infiltration in pancreatic ductal adenocarcinoma in relation to desmoplastic stroma is unclear. Here the authors develop a method to spatially resolve tumour stroma composition and find that spatial T-cell infiltration correlates with patient prognosis regardless of desmoplasia.Julienne L. CarstensPedro Correa de SampaioDalu YangSouptik BaruaHuamin WangArvind RaoJames P. AllisonValerie S. LeBleuRaghu KalluriNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Julienne L. Carstens Pedro Correa de Sampaio Dalu Yang Souptik Barua Huamin Wang Arvind Rao James P. Allison Valerie S. LeBleu Raghu Kalluri Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer
description	The functional significance of T-cell infiltration in pancreatic ductal adenocarcinoma in relation to desmoplastic stroma is unclear. Here the authors develop a method to spatially resolve tumour stroma composition and find that spatial T-cell infiltration correlates with patient prognosis regardless of desmoplasia.
format	article
author	Julienne L. Carstens Pedro Correa de Sampaio Dalu Yang Souptik Barua Huamin Wang Arvind Rao James P. Allison Valerie S. LeBleu Raghu Kalluri
author_facet	Julienne L. Carstens Pedro Correa de Sampaio Dalu Yang Souptik Barua Huamin Wang Arvind Rao James P. Allison Valerie S. LeBleu Raghu Kalluri
author_sort	Julienne L. Carstens
title	Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer
title_short	Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer
title_full	Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer
title_fullStr	Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer
title_full_unstemmed	Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer
title_sort	spatial computation of intratumoral t cells correlates with survival of patients with pancreatic cancer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6a442765a1b54d688e2663f994aa8df6
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Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer

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