Methamphetamine increases locomotion and dopamine transporter activity in dopamine d5 receptor-deficient mice.

Dopamine regulates the psychomotor stimulant activities of amphetamine-like substances in the brain. The effects of dopamine are mediated through five known dopamine receptor subtypes in mammals. The functional relevance of D5 dopamine receptors in the central nervous system is not well understood....

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Autores principales:	Seiji Hayashizaki, Shinobu Hirai, Yumi Ito, Yoshiko Honda, Yosefu Arime, Ichiro Sora, Haruo Okado, Tohru Kodama, Masahiko Takada
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6a4671a1bceb400a8c27c908ded610bf
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spelling	oai:doaj.org-article:6a4671a1bceb400a8c27c908ded610bf2021-11-18T08:51:18ZMethamphetamine increases locomotion and dopamine transporter activity in dopamine d5 receptor-deficient mice.1932-620310.1371/journal.pone.0075975https://doaj.org/article/6a4671a1bceb400a8c27c908ded610bf2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24155877/?tool=EBIhttps://doaj.org/toc/1932-6203Dopamine regulates the psychomotor stimulant activities of amphetamine-like substances in the brain. The effects of dopamine are mediated through five known dopamine receptor subtypes in mammals. The functional relevance of D5 dopamine receptors in the central nervous system is not well understood. To determine the functional relevance of D5 dopamine receptors, we created D5 dopamine receptor-deficient mice and then used these mice to assess the roles of D5 dopamine receptors in the behavioral response to methamphetamine. Interestingly, D5 dopamine receptor-deficient mice displayed increased ambulation in response to methamphetamine. Furthermore, dopamine transporter threonine phosphorylation levels, which regulate amphetamine-induced dopamine release, were elevated in D5 dopamine receptor-deficient mice. The increase in methamphetamine-induced locomotor activity was eliminated by pretreatment with the dopamine transporter blocker GBR12909. Taken together, these results suggest that dopamine transporter activity and threonine phosphorylation levels are regulated by D5 dopamine receptors.Seiji HayashizakiShinobu HiraiYumi ItoYoshiko HondaYosefu ArimeIchiro SoraHaruo OkadoTohru KodamaMasahiko TakadaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 10, p e75975 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Seiji Hayashizaki Shinobu Hirai Yumi Ito Yoshiko Honda Yosefu Arime Ichiro Sora Haruo Okado Tohru Kodama Masahiko Takada Methamphetamine increases locomotion and dopamine transporter activity in dopamine d5 receptor-deficient mice.
description	Dopamine regulates the psychomotor stimulant activities of amphetamine-like substances in the brain. The effects of dopamine are mediated through five known dopamine receptor subtypes in mammals. The functional relevance of D5 dopamine receptors in the central nervous system is not well understood. To determine the functional relevance of D5 dopamine receptors, we created D5 dopamine receptor-deficient mice and then used these mice to assess the roles of D5 dopamine receptors in the behavioral response to methamphetamine. Interestingly, D5 dopamine receptor-deficient mice displayed increased ambulation in response to methamphetamine. Furthermore, dopamine transporter threonine phosphorylation levels, which regulate amphetamine-induced dopamine release, were elevated in D5 dopamine receptor-deficient mice. The increase in methamphetamine-induced locomotor activity was eliminated by pretreatment with the dopamine transporter blocker GBR12909. Taken together, these results suggest that dopamine transporter activity and threonine phosphorylation levels are regulated by D5 dopamine receptors.
format	article
author	Seiji Hayashizaki Shinobu Hirai Yumi Ito Yoshiko Honda Yosefu Arime Ichiro Sora Haruo Okado Tohru Kodama Masahiko Takada
author_facet	Seiji Hayashizaki Shinobu Hirai Yumi Ito Yoshiko Honda Yosefu Arime Ichiro Sora Haruo Okado Tohru Kodama Masahiko Takada
author_sort	Seiji Hayashizaki
title	Methamphetamine increases locomotion and dopamine transporter activity in dopamine d5 receptor-deficient mice.
title_short	Methamphetamine increases locomotion and dopamine transporter activity in dopamine d5 receptor-deficient mice.
title_full	Methamphetamine increases locomotion and dopamine transporter activity in dopamine d5 receptor-deficient mice.
title_fullStr	Methamphetamine increases locomotion and dopamine transporter activity in dopamine d5 receptor-deficient mice.
title_full_unstemmed	Methamphetamine increases locomotion and dopamine transporter activity in dopamine d5 receptor-deficient mice.
title_sort	methamphetamine increases locomotion and dopamine transporter activity in dopamine d5 receptor-deficient mice.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/6a4671a1bceb400a8c27c908ded610bf
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Methamphetamine increases locomotion and dopamine transporter activity in dopamine d5 receptor-deficient mice.

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