A modular self-adjuvanting cancer vaccine combined with an oncolytic vaccine induces potent antitumor immunity

Successful cancer immune therapy correlates with a T cell-inflamed tumour microenvironment. Authors show here that co-administration of a self-adjuvanting protein vaccine and an antigen-expressing oncolytic virus in an optimised regimen strongly enhances T cell immunogenicity and may turn non-inflam...

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Autores principales:	Krishna Das, Elodie Belnoue, Matteo Rossi, Tamara Hofer, Sarah Danklmaier, Tobias Nolden, Liesa-Marie Schreiber, Katharina Angerer, Janine Kimpel, Sandra Hoegler, Bart Spiesschaert, Lukas Kenner, Dorothee von Laer, Knut Elbers, Madiha Derouazi, Guido Wollmann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6a4885a11bbe41c6aef5c595a4d1525a
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spelling	oai:doaj.org-article:6a4885a11bbe41c6aef5c595a4d1525a2021-12-02T19:10:37ZA modular self-adjuvanting cancer vaccine combined with an oncolytic vaccine induces potent antitumor immunity10.1038/s41467-021-25506-62041-1723https://doaj.org/article/6a4885a11bbe41c6aef5c595a4d1525a2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25506-6https://doaj.org/toc/2041-1723Successful cancer immune therapy correlates with a T cell-inflamed tumour microenvironment. Authors show here that co-administration of a self-adjuvanting protein vaccine and an antigen-expressing oncolytic virus in an optimised regimen strongly enhances T cell immunogenicity and may turn non-inflamed tumours proinflammatory and less resistant to checkpoint blockade therapy.Krishna DasElodie BelnoueMatteo RossiTamara HoferSarah DanklmaierTobias NoldenLiesa-Marie SchreiberKatharina AngererJanine KimpelSandra HoeglerBart SpiesschaertLukas KennerDorothee von LaerKnut ElbersMadiha DerouaziGuido WollmannNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Krishna Das Elodie Belnoue Matteo Rossi Tamara Hofer Sarah Danklmaier Tobias Nolden Liesa-Marie Schreiber Katharina Angerer Janine Kimpel Sandra Hoegler Bart Spiesschaert Lukas Kenner Dorothee von Laer Knut Elbers Madiha Derouazi Guido Wollmann A modular self-adjuvanting cancer vaccine combined with an oncolytic vaccine induces potent antitumor immunity
description	Successful cancer immune therapy correlates with a T cell-inflamed tumour microenvironment. Authors show here that co-administration of a self-adjuvanting protein vaccine and an antigen-expressing oncolytic virus in an optimised regimen strongly enhances T cell immunogenicity and may turn non-inflamed tumours proinflammatory and less resistant to checkpoint blockade therapy.
format	article
author	Krishna Das Elodie Belnoue Matteo Rossi Tamara Hofer Sarah Danklmaier Tobias Nolden Liesa-Marie Schreiber Katharina Angerer Janine Kimpel Sandra Hoegler Bart Spiesschaert Lukas Kenner Dorothee von Laer Knut Elbers Madiha Derouazi Guido Wollmann
author_facet	Krishna Das Elodie Belnoue Matteo Rossi Tamara Hofer Sarah Danklmaier Tobias Nolden Liesa-Marie Schreiber Katharina Angerer Janine Kimpel Sandra Hoegler Bart Spiesschaert Lukas Kenner Dorothee von Laer Knut Elbers Madiha Derouazi Guido Wollmann
author_sort	Krishna Das
title	A modular self-adjuvanting cancer vaccine combined with an oncolytic vaccine induces potent antitumor immunity
title_short	A modular self-adjuvanting cancer vaccine combined with an oncolytic vaccine induces potent antitumor immunity
title_full	A modular self-adjuvanting cancer vaccine combined with an oncolytic vaccine induces potent antitumor immunity
title_fullStr	A modular self-adjuvanting cancer vaccine combined with an oncolytic vaccine induces potent antitumor immunity
title_full_unstemmed	A modular self-adjuvanting cancer vaccine combined with an oncolytic vaccine induces potent antitumor immunity
title_sort	modular self-adjuvanting cancer vaccine combined with an oncolytic vaccine induces potent antitumor immunity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6a4885a11bbe41c6aef5c595a4d1525a
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A modular self-adjuvanting cancer vaccine combined with an oncolytic vaccine induces potent antitumor immunity

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