Fecal short chain fatty acids in children living on farms and a link between valeric acid and protection from eczema

Abstract Children growing up on farms have low rates of allergy, but the mechanism for this protective effect has not been fully elucidated. Short chain fatty acids (SCFAs) produced by the gut microbiota may play a role in protection from allergy. We measured fecal SCFA levels in samples collected f...

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Autores principales:	Monica Gio-Batta, Fei Sjöberg, Karin Jonsson, Malin Barman, Anna-Carin Lundell, Ingegerd Adlerberth, Bill Hesselmar, Ann-Sofie Sandberg, Agnes E. Wold
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6a4a7f12d4de40ffa1155e0b261db6e1
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spelling	oai:doaj.org-article:6a4a7f12d4de40ffa1155e0b261db6e12021-12-02T14:01:27ZFecal short chain fatty acids in children living on farms and a link between valeric acid and protection from eczema10.1038/s41598-020-79737-62045-2322https://doaj.org/article/6a4a7f12d4de40ffa1155e0b261db6e12020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79737-6https://doaj.org/toc/2045-2322Abstract Children growing up on farms have low rates of allergy, but the mechanism for this protective effect has not been fully elucidated. Short chain fatty acids (SCFAs) produced by the gut microbiota may play a role in protection from allergy. We measured fecal SCFA levels in samples collected from 28 farming and 37 control children over the first 3 years of life using gas chromatography. Data on diet and other host factors were recorded and allergy was diagnosed at 8 years of age. Among all children, median propionic and butyric acid concentration increased over the first 3 years, and longer SCFAs typically appeared by 1 year of age. Farm children had higher levels of iso-butyric, iso-valeric and valeric acid at 3 years of age than rural controls. In addition, children with elder siblings had higher levels of valeric acid at 3 years of age, and dietary factors also affected SCFA pattern. High levels of valeric acid at 3 years of age were associated with low rate of eczema at 8 years of age. The fecal SCFA pattern in farm children suggests a more rapid maturation of the gut microbiota. Valeric acid or associated microbes may have protective potential against eczema.Monica Gio-BattaFei SjöbergKarin JonssonMalin BarmanAnna-Carin LundellIngegerd AdlerberthBill HesselmarAnn-Sofie SandbergAgnes E. WoldNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Monica Gio-Batta Fei Sjöberg Karin Jonsson Malin Barman Anna-Carin Lundell Ingegerd Adlerberth Bill Hesselmar Ann-Sofie Sandberg Agnes E. Wold Fecal short chain fatty acids in children living on farms and a link between valeric acid and protection from eczema
description	Abstract Children growing up on farms have low rates of allergy, but the mechanism for this protective effect has not been fully elucidated. Short chain fatty acids (SCFAs) produced by the gut microbiota may play a role in protection from allergy. We measured fecal SCFA levels in samples collected from 28 farming and 37 control children over the first 3 years of life using gas chromatography. Data on diet and other host factors were recorded and allergy was diagnosed at 8 years of age. Among all children, median propionic and butyric acid concentration increased over the first 3 years, and longer SCFAs typically appeared by 1 year of age. Farm children had higher levels of iso-butyric, iso-valeric and valeric acid at 3 years of age than rural controls. In addition, children with elder siblings had higher levels of valeric acid at 3 years of age, and dietary factors also affected SCFA pattern. High levels of valeric acid at 3 years of age were associated with low rate of eczema at 8 years of age. The fecal SCFA pattern in farm children suggests a more rapid maturation of the gut microbiota. Valeric acid or associated microbes may have protective potential against eczema.
format	article
author	Monica Gio-Batta Fei Sjöberg Karin Jonsson Malin Barman Anna-Carin Lundell Ingegerd Adlerberth Bill Hesselmar Ann-Sofie Sandberg Agnes E. Wold
author_facet	Monica Gio-Batta Fei Sjöberg Karin Jonsson Malin Barman Anna-Carin Lundell Ingegerd Adlerberth Bill Hesselmar Ann-Sofie Sandberg Agnes E. Wold
author_sort	Monica Gio-Batta
title	Fecal short chain fatty acids in children living on farms and a link between valeric acid and protection from eczema
title_short	Fecal short chain fatty acids in children living on farms and a link between valeric acid and protection from eczema
title_full	Fecal short chain fatty acids in children living on farms and a link between valeric acid and protection from eczema
title_fullStr	Fecal short chain fatty acids in children living on farms and a link between valeric acid and protection from eczema
title_full_unstemmed	Fecal short chain fatty acids in children living on farms and a link between valeric acid and protection from eczema
title_sort	fecal short chain fatty acids in children living on farms and a link between valeric acid and protection from eczema
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6a4a7f12d4de40ffa1155e0b261db6e1
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Fecal short chain fatty acids in children living on farms and a link between valeric acid and protection from eczema

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