Experimental Validation of the MRcollar: An MR Compatible Applicator for Deep Heating in the Head and Neck Region

Clinical effectiveness of hyperthermia treatments, in which tumor tissue is artificially heated to 40–44 °C for 60–90 min, can be hampered by a lack of accurate temperature monitoring. The need for noninvasive temperature monitoring in the head and neck region (H&N) and the potential of MR therm...

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Autores principales:	Kemal Sumser, Tomas Drizdal, Gennaro G. Bellizzi, Juan A. Hernandez-Tamames, Gerard C. van Rhoon, Margarethus Marius Paulides
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hyperthermia microwave hyperthermia MR thermometry MRI guided interventions Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/6a4e76181e06469a9ea1b74f8af28b08
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spelling	oai:doaj.org-article:6a4e76181e06469a9ea1b74f8af28b082021-11-25T17:01:40ZExperimental Validation of the MRcollar: An MR Compatible Applicator for Deep Heating in the Head and Neck Region10.3390/cancers132256172072-6694https://doaj.org/article/6a4e76181e06469a9ea1b74f8af28b082021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5617https://doaj.org/toc/2072-6694Clinical effectiveness of hyperthermia treatments, in which tumor tissue is artificially heated to 40–44 °C for 60–90 min, can be hampered by a lack of accurate temperature monitoring. The need for noninvasive temperature monitoring in the head and neck region (H&N) and the potential of MR thermometry prompt us to design an MR compatible hyperthermia applicator: the MRcollar. In this work, we validate the design, numerical model, and MR performance of the MRcollar. The MRcollar antennas have low reflection coefficients (<−15 dB) and the intended low interaction between the individual antenna modules (<−32 dB). A 10 °C increase in 3 min was reached in a muscle-equivalent phantom, such that the specifications from the European Society for Hyperthermic Oncology were easily reached. The MRcollar had a minimal effect on MR image quality and a five-fold improvement in SNR was achieved using the integrated coils of the MRcollar, compared to the body coil. The feasibility of using the MRcollar in an MR environment was shown by a synchronous heating experiment. The match between the predicted SAR and measured SAR using MR thermometry satisfied the gamma criteria [distance-to-agreement = 5 mm, dose-difference = 7%]. All experiments combined show that the MRcollar delivers on the needs for MR—hyperthermia in the H&N and is ready for in vivo investigation.Kemal SumserTomas DrizdalGennaro G. BellizziJuan A. Hernandez-TamamesGerard C. van RhoonMargarethus Marius PaulidesMDPI AGarticlehyperthermiamicrowave hyperthermiaMR thermometryMRI guided interventionsNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5617, p 5617 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hyperthermia microwave hyperthermia MR thermometry MRI guided interventions Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	hyperthermia microwave hyperthermia MR thermometry MRI guided interventions Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Kemal Sumser Tomas Drizdal Gennaro G. Bellizzi Juan A. Hernandez-Tamames Gerard C. van Rhoon Margarethus Marius Paulides Experimental Validation of the MRcollar: An MR Compatible Applicator for Deep Heating in the Head and Neck Region
description	Clinical effectiveness of hyperthermia treatments, in which tumor tissue is artificially heated to 40–44 °C for 60–90 min, can be hampered by a lack of accurate temperature monitoring. The need for noninvasive temperature monitoring in the head and neck region (H&N) and the potential of MR thermometry prompt us to design an MR compatible hyperthermia applicator: the MRcollar. In this work, we validate the design, numerical model, and MR performance of the MRcollar. The MRcollar antennas have low reflection coefficients (<−15 dB) and the intended low interaction between the individual antenna modules (<−32 dB). A 10 °C increase in 3 min was reached in a muscle-equivalent phantom, such that the specifications from the European Society for Hyperthermic Oncology were easily reached. The MRcollar had a minimal effect on MR image quality and a five-fold improvement in SNR was achieved using the integrated coils of the MRcollar, compared to the body coil. The feasibility of using the MRcollar in an MR environment was shown by a synchronous heating experiment. The match between the predicted SAR and measured SAR using MR thermometry satisfied the gamma criteria [distance-to-agreement = 5 mm, dose-difference = 7%]. All experiments combined show that the MRcollar delivers on the needs for MR—hyperthermia in the H&N and is ready for in vivo investigation.
format	article
author	Kemal Sumser Tomas Drizdal Gennaro G. Bellizzi Juan A. Hernandez-Tamames Gerard C. van Rhoon Margarethus Marius Paulides
author_facet	Kemal Sumser Tomas Drizdal Gennaro G. Bellizzi Juan A. Hernandez-Tamames Gerard C. van Rhoon Margarethus Marius Paulides
author_sort	Kemal Sumser
title	Experimental Validation of the MRcollar: An MR Compatible Applicator for Deep Heating in the Head and Neck Region
title_short	Experimental Validation of the MRcollar: An MR Compatible Applicator for Deep Heating in the Head and Neck Region
title_full	Experimental Validation of the MRcollar: An MR Compatible Applicator for Deep Heating in the Head and Neck Region
title_fullStr	Experimental Validation of the MRcollar: An MR Compatible Applicator for Deep Heating in the Head and Neck Region
title_full_unstemmed	Experimental Validation of the MRcollar: An MR Compatible Applicator for Deep Heating in the Head and Neck Region
title_sort	experimental validation of the mrcollar: an mr compatible applicator for deep heating in the head and neck region
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6a4e76181e06469a9ea1b74f8af28b08
work_keys_str_mv	AT kemalsumser experimentalvalidationofthemrcollaranmrcompatibleapplicatorfordeepheatingintheheadandneckregion AT tomasdrizdal experimentalvalidationofthemrcollaranmrcompatibleapplicatorfordeepheatingintheheadandneckregion AT gennarogbellizzi experimentalvalidationofthemrcollaranmrcompatibleapplicatorfordeepheatingintheheadandneckregion AT juanahernandeztamames experimentalvalidationofthemrcollaranmrcompatibleapplicatorfordeepheatingintheheadandneckregion AT gerardcvanrhoon experimentalvalidationofthemrcollaranmrcompatibleapplicatorfordeepheatingintheheadandneckregion AT margarethusmariuspaulides experimentalvalidationofthemrcollaranmrcompatibleapplicatorfordeepheatingintheheadandneckregion
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Experimental Validation of the MRcollar: An MR Compatible Applicator for Deep Heating in the Head and Neck Region

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