Macular laser photocoagulation guided by spectral-domain optical coherence tomography versus fluorescein angiography for diabetic macular edema

Roberto Gallego-Pinazo1,2, Ana Marina Suelves-Cogollos1, Rosa Dolz-Marco1, J Fernando Arevalo3, Salvador Garc&iacute;a-Delpech1, J Luis Mullor4, Manuel D&iacute;az-Llopis1,2,51Department of Ophthalmology, Hospital Universitario La Fe, Valencia, Spain; 2Centro de Investigaci&o...

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Autores principales:	Gallego-Pinazo R, Suelves AM, Dolz-Marco R, Arevalo JF, Garcia-Delpech S, Mullor JL, Diaz-Llopis M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/6a4ee7a14825462f9f4a4b9c39ec68fa
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spelling	oai:doaj.org-article:6a4ee7a14825462f9f4a4b9c39ec68fa2021-12-02T06:06:47ZMacular laser photocoagulation guided by spectral-domain optical coherence tomography versus fluorescein angiography for diabetic macular edema1177-54671177-5483https://doaj.org/article/6a4ee7a14825462f9f4a4b9c39ec68fa2011-05-01T00:00:00Zhttp://www.dovepress.com/macular-laser-photocoagulation-guided-by-spectral-domain-optical-coher-a7458https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Roberto Gallego-Pinazo1,2, Ana Marina Suelves-Cogollos1, Rosa Dolz-Marco1, J Fernando Arevalo3, Salvador Garc&iacute;a-Delpech1, J Luis Mullor4, Manuel D&iacute;az-Llopis1,2,51Department of Ophthalmology, Hospital Universitario La Fe, Valencia, Spain; 2Centro de Investigaci&oacute;n Biom&eacute;dica en Red de Enfermedades Raras, Valencia, Spain; 3Retina and Vitreous Service, Clinical Ophthalmology Center, Caracas, Venezuela; 4Unit of Experimental Ophthalmology, Hospital Universitario La Fe, Valencia, Spain; 5University of Valencia, Faculty of Medicine, Valencia, SpainBackground: The aim of this study was to compare the efficacy of spectral-domain optical coherence tomography (SD-OCT) and fluorescein angiography (FA) in the guidance of macular laser photocoagulation for diabetic macular edema.Methods: This was a prospective interventional clinical comparative pilot study. Forty eyes from 24 consecutive patients with diabetic macular edema were allocated to receive laser photocoagulation guided by SD-OCT or FA. Best-corrected visual acuity (BCVA), central macular thickness, and retinal volume were assessed at baseline and two months after treatment.Results: Subjects treated using FA-guided laser improved BCVA from the logarithm of the minimum angle of resolution (logMAR) 0.52 &plusmn; 0.2 to 0.37 &plusmn; 0.2 (P &lt; 0.001), and decreased mean central macular thickness from 397.25 &plusmn; 139.1 to 333.50 &plusmn; 105.7 &micro;m (P &lt; 0.001) and retinal volume from 12.61 &plusmn; 1.6 to 10.94 &plusmn; 1.4 mm3 (P &lt; 0.001). Subjects treated using SD-OCT guided laser had improved BCVA from 0.48 &plusmn; 0.2 to 0.33 &plusmn; 0.2 logMAR (P &lt; 0.001), and decreased mean central macular thickness from 425.90 &plusmn; 149.6 to 353.4 &plusmn; 140 &micro;m (P &lt; 0.001) and retinal volume from 12.38 &plusmn; 2.1 to 11.53 &plusmn; 1.1 mm3 (P &lt; 0.001). No significant differences between the groups were found in two-month BCVA (P = 0.505), two-month central macular thickness (P = 0.660), or two-month retinal volume (P = 0.582).Conclusion: The short-term results of this pilot study suggest that SD-OCT is a safe and effective technique and could be considered as a valid alternative to FA in the guidance of macular laser photocoagulation treatment for diabetic macular edema.Keywords: spectral-domain optical coherence tomography, fluorescein angiography, macular laser photocoagulation, diabetic macular edemaGallego-Pinazo RSuelves AMDolz-Marco RArevalo JFGarcia-Delpech SMullor JLDiaz-Llopis MDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2011, Iss default, Pp 613-617 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Gallego-Pinazo R Suelves AM Dolz-Marco R Arevalo JF Garcia-Delpech S Mullor JL Diaz-Llopis M Macular laser photocoagulation guided by spectral-domain optical coherence tomography versus fluorescein angiography for diabetic macular edema
description	Roberto Gallego-Pinazo1,2, Ana Marina Suelves-Cogollos1, Rosa Dolz-Marco1, J Fernando Arevalo3, Salvador Garc&iacute;a-Delpech1, J Luis Mullor4, Manuel D&iacute;az-Llopis1,2,51Department of Ophthalmology, Hospital Universitario La Fe, Valencia, Spain; 2Centro de Investigaci&oacute;n Biom&eacute;dica en Red de Enfermedades Raras, Valencia, Spain; 3Retina and Vitreous Service, Clinical Ophthalmology Center, Caracas, Venezuela; 4Unit of Experimental Ophthalmology, Hospital Universitario La Fe, Valencia, Spain; 5University of Valencia, Faculty of Medicine, Valencia, SpainBackground: The aim of this study was to compare the efficacy of spectral-domain optical coherence tomography (SD-OCT) and fluorescein angiography (FA) in the guidance of macular laser photocoagulation for diabetic macular edema.Methods: This was a prospective interventional clinical comparative pilot study. Forty eyes from 24 consecutive patients with diabetic macular edema were allocated to receive laser photocoagulation guided by SD-OCT or FA. Best-corrected visual acuity (BCVA), central macular thickness, and retinal volume were assessed at baseline and two months after treatment.Results: Subjects treated using FA-guided laser improved BCVA from the logarithm of the minimum angle of resolution (logMAR) 0.52 &plusmn; 0.2 to 0.37 &plusmn; 0.2 (P &lt; 0.001), and decreased mean central macular thickness from 397.25 &plusmn; 139.1 to 333.50 &plusmn; 105.7 &micro;m (P &lt; 0.001) and retinal volume from 12.61 &plusmn; 1.6 to 10.94 &plusmn; 1.4 mm3 (P &lt; 0.001). Subjects treated using SD-OCT guided laser had improved BCVA from 0.48 &plusmn; 0.2 to 0.33 &plusmn; 0.2 logMAR (P &lt; 0.001), and decreased mean central macular thickness from 425.90 &plusmn; 149.6 to 353.4 &plusmn; 140 &micro;m (P &lt; 0.001) and retinal volume from 12.38 &plusmn; 2.1 to 11.53 &plusmn; 1.1 mm3 (P &lt; 0.001). No significant differences between the groups were found in two-month BCVA (P = 0.505), two-month central macular thickness (P = 0.660), or two-month retinal volume (P = 0.582).Conclusion: The short-term results of this pilot study suggest that SD-OCT is a safe and effective technique and could be considered as a valid alternative to FA in the guidance of macular laser photocoagulation treatment for diabetic macular edema.Keywords: spectral-domain optical coherence tomography, fluorescein angiography, macular laser photocoagulation, diabetic macular edema
format	article
author	Gallego-Pinazo R Suelves AM Dolz-Marco R Arevalo JF Garcia-Delpech S Mullor JL Diaz-Llopis M
author_facet	Gallego-Pinazo R Suelves AM Dolz-Marco R Arevalo JF Garcia-Delpech S Mullor JL Diaz-Llopis M
author_sort	Gallego-Pinazo R
title	Macular laser photocoagulation guided by spectral-domain optical coherence tomography versus fluorescein angiography for diabetic macular edema
title_short	Macular laser photocoagulation guided by spectral-domain optical coherence tomography versus fluorescein angiography for diabetic macular edema
title_full	Macular laser photocoagulation guided by spectral-domain optical coherence tomography versus fluorescein angiography for diabetic macular edema
title_fullStr	Macular laser photocoagulation guided by spectral-domain optical coherence tomography versus fluorescein angiography for diabetic macular edema
title_full_unstemmed	Macular laser photocoagulation guided by spectral-domain optical coherence tomography versus fluorescein angiography for diabetic macular edema
title_sort	macular laser photocoagulation guided by spectral-domain optical coherence tomography versus fluorescein angiography for diabetic macular edema
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/6a4ee7a14825462f9f4a4b9c39ec68fa
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Macular laser photocoagulation guided by spectral-domain optical coherence tomography versus fluorescein angiography for diabetic macular edema

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