Myeloid-derived interleukin-1β drives oncogenic KRAS-NF-κΒ addiction in malignant pleural effusion

Myeloid-derived interleukin-1β drives oncogenic KRAS-NF-κΒ addiction in malignant pleural effusion

Malignant pleural effusion (MPE) is a life-threatening cancer-related disorder. Here, the authors show that KRAS-mutant tumor cells require IKKα, activated via host-provided IL-1β, to promote MPE development and that co-inhibition of both KRAS and IKKα ameliorates the development of MPE in mouse mod...

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Autores principales: Antonia Marazioti, Ioannis Lilis, Malamati Vreka, Hara Apostolopoulou, Argyro Kalogeropoulou, Ioanna Giopanou, Georgia A. Giotopoulou, Anthi C. Krontira, Marianthi Iliopoulou, Nikolaos I. Kanellakis, Theodora Agalioti, Anastasios D. Giannou, Celestial Jones-Paris, Yoichiro Iwakura, Dimitrios Kardamakis, Timothy S. Blackwell, Stavros Taraviras, Magda Spella, Georgios T. Stathopoulos
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/6a500ee17a8443c4ad3c2fbe668a22da
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spelling oai:doaj.org-article:6a500ee17a8443c4ad3c2fbe668a22da2021-12-02T14:39:08ZMyeloid-derived interleukin-1β drives oncogenic KRAS-NF-κΒ addiction in malignant pleural effusion10.1038/s41467-018-03051-z2041-1723https://doaj.org/article/6a500ee17a8443c4ad3c2fbe668a22da2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03051-zhttps://doaj.org/toc/2041-1723Malignant pleural effusion (MPE) is a life-threatening cancer-related disorder. Here, the authors show that KRAS-mutant tumor cells require IKKα, activated via host-provided IL-1β, to promote MPE development and that co-inhibition of both KRAS and IKKα ameliorates the development of MPE in mouse models.Antonia MaraziotiIoannis LilisMalamati VrekaHara ApostolopoulouArgyro KalogeropoulouIoanna GiopanouGeorgia A. GiotopoulouAnthi C. KrontiraMarianthi IliopoulouNikolaos I. KanellakisTheodora AgaliotiAnastasios D. GiannouCelestial Jones-ParisYoichiro IwakuraDimitrios KardamakisTimothy S. BlackwellStavros TaravirasMagda SpellaGeorgios T. StathopoulosNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Antonia Marazioti
Ioannis Lilis
Malamati Vreka
Hara Apostolopoulou
Argyro Kalogeropoulou
Ioanna Giopanou
Georgia A. Giotopoulou
Anthi C. Krontira
Marianthi Iliopoulou
Nikolaos I. Kanellakis
Theodora Agalioti
Anastasios D. Giannou
Celestial Jones-Paris
Yoichiro Iwakura
Dimitrios Kardamakis
Timothy S. Blackwell
Stavros Taraviras
Magda Spella
Georgios T. Stathopoulos
Myeloid-derived interleukin-1β drives oncogenic KRAS-NF-κΒ addiction in malignant pleural effusion
description Malignant pleural effusion (MPE) is a life-threatening cancer-related disorder. Here, the authors show that KRAS-mutant tumor cells require IKKα, activated via host-provided IL-1β, to promote MPE development and that co-inhibition of both KRAS and IKKα ameliorates the development of MPE in mouse models.
format article
author Antonia Marazioti
Ioannis Lilis
Malamati Vreka
Hara Apostolopoulou
Argyro Kalogeropoulou
Ioanna Giopanou
Georgia A. Giotopoulou
Anthi C. Krontira
Marianthi Iliopoulou
Nikolaos I. Kanellakis
Theodora Agalioti
Anastasios D. Giannou
Celestial Jones-Paris
Yoichiro Iwakura
Dimitrios Kardamakis
Timothy S. Blackwell
Stavros Taraviras
Magda Spella
Georgios T. Stathopoulos
author_facet Antonia Marazioti
Ioannis Lilis
Malamati Vreka
Hara Apostolopoulou
Argyro Kalogeropoulou
Ioanna Giopanou
Georgia A. Giotopoulou
Anthi C. Krontira
Marianthi Iliopoulou
Nikolaos I. Kanellakis
Theodora Agalioti
Anastasios D. Giannou
Celestial Jones-Paris
Yoichiro Iwakura
Dimitrios Kardamakis
Timothy S. Blackwell
Stavros Taraviras
Magda Spella
Georgios T. Stathopoulos
author_sort Antonia Marazioti
title Myeloid-derived interleukin-1β drives oncogenic KRAS-NF-κΒ addiction in malignant pleural effusion
title_short Myeloid-derived interleukin-1β drives oncogenic KRAS-NF-κΒ addiction in malignant pleural effusion
title_full Myeloid-derived interleukin-1β drives oncogenic KRAS-NF-κΒ addiction in malignant pleural effusion
title_fullStr Myeloid-derived interleukin-1β drives oncogenic KRAS-NF-κΒ addiction in malignant pleural effusion
title_full_unstemmed Myeloid-derived interleukin-1β drives oncogenic KRAS-NF-κΒ addiction in malignant pleural effusion
title_sort myeloid-derived interleukin-1β drives oncogenic kras-nf-κβ addiction in malignant pleural effusion
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/6a500ee17a8443c4ad3c2fbe668a22da
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