P2RX7 gene variation mediates the effect of childhood adversity and recent stress on the severity of depressive symptoms.

The P2X purinoceptor 7 (P2RX7) mediates inflammatory microglial responses and is implicated in neuroimmune mechanisms of depression and neurodegenerative disorders. A number of studies suggest that psychosocial stress may precipitate depression through immune activation. Genetic association studies...

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Autores principales: Zsuliet Kristof, Nora Eszlari, Sara Sutori, Zsofia Gal, Dora Torok, Daniel Baksa, Peter Petschner, Beata Sperlagh, Ian M Anderson, John Francis William Deakin, Gabriella Juhasz, Gyorgy Bagdy, Xenia Gonda
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
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Acceso en línea:https://doaj.org/article/6a53842c27204f458916cea46a0bd37e
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