P2RX7 gene variation mediates the effect of childhood adversity and recent stress on the severity of depressive symptoms.

P2RX7 gene variation mediates the effect of childhood adversity and recent stress on the severity of depressive symptoms.

The P2X purinoceptor 7 (P2RX7) mediates inflammatory microglial responses and is implicated in neuroimmune mechanisms of depression and neurodegenerative disorders. A number of studies suggest that psychosocial stress may precipitate depression through immune activation. Genetic association studies...

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Main Authors: Zsuliet Kristof, Nora Eszlari, Sara Sutori, Zsofia Gal, Dora Torok, Daniel Baksa, Peter Petschner, Beata Sperlagh, Ian M Anderson, John Francis William Deakin, Gabriella Juhasz, Gyorgy Bagdy, Xenia Gonda
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2021
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/6a53842c27204f458916cea46a0bd37e
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https://doaj.org/article/6a53842c27204f458916cea46a0bd37e

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