AKAP95 regulates splicing through scaffolding RNAs and RNA processing factors

The chromatin-associated protein AKAP95 is known for its chromatin-related functions including enhancing transcription. Here the authors show that AKAP95 interacts with the splicing regulatory factors as well as RNAs to regulate the inclusion of exons and pre-mRNA splicing.

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Auteurs principaux: Jing Hu, Alireza Khodadadi-Jamayran, Miaowei Mao, Kushani Shah, Zhenhua Yang, Md Talat Nasim, Zefeng Wang, Hao Jiang
Format: article
Langue:EN
Publié: Nature Portfolio 2016
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Accès en ligne:https://doaj.org/article/6a5530b190df4e898f5958aba3f4b5b3
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Résumé:The chromatin-associated protein AKAP95 is known for its chromatin-related functions including enhancing transcription. Here the authors show that AKAP95 interacts with the splicing regulatory factors as well as RNAs to regulate the inclusion of exons and pre-mRNA splicing.