NatD promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate Slug expression
NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulati...
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Nature Portfolio
2017
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oai:doaj.org-article:6a59395fcee24917b56f36386d89135b2021-12-02T14:40:48ZNatD promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate Slug expression10.1038/s41467-017-00988-52041-1723https://doaj.org/article/6a59395fcee24917b56f36386d89135b2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00988-5https://doaj.org/toc/2041-1723NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.Junyi JuAiping ChenYexuan DengMing LiuYing WangYadong WangMin NieChao WangHong DingBing YaoTao GuiXinyu LiZhen XuChi MaYong SongMarc KvansakulKe ZenChen-Yu ZhangCheng LuoMing FangDavid C. S. HuangC. David AllisRenxiang TanChangjiang Kathy ZengJiwu WeiQuan ZhaoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Junyi Ju Aiping Chen Yexuan Deng Ming Liu Ying Wang Yadong Wang Min Nie Chao Wang Hong Ding Bing Yao Tao Gui Xinyu Li Zhen Xu Chi Ma Yong Song Marc Kvansakul Ke Zen Chen-Yu Zhang Cheng Luo Ming Fang David C. S. Huang C. David Allis Renxiang Tan Changjiang Kathy Zeng Jiwu Wei Quan Zhao NatD promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate Slug expression |
| description |
NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression. |
| format |
article |
| author |
Junyi Ju Aiping Chen Yexuan Deng Ming Liu Ying Wang Yadong Wang Min Nie Chao Wang Hong Ding Bing Yao Tao Gui Xinyu Li Zhen Xu Chi Ma Yong Song Marc Kvansakul Ke Zen Chen-Yu Zhang Cheng Luo Ming Fang David C. S. Huang C. David Allis Renxiang Tan Changjiang Kathy Zeng Jiwu Wei Quan Zhao |
| author_facet |
Junyi Ju Aiping Chen Yexuan Deng Ming Liu Ying Wang Yadong Wang Min Nie Chao Wang Hong Ding Bing Yao Tao Gui Xinyu Li Zhen Xu Chi Ma Yong Song Marc Kvansakul Ke Zen Chen-Yu Zhang Cheng Luo Ming Fang David C. S. Huang C. David Allis Renxiang Tan Changjiang Kathy Zeng Jiwu Wei Quan Zhao |
| author_sort |
Junyi Ju |
| title |
NatD promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate Slug expression |
| title_short |
NatD promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate Slug expression |
| title_full |
NatD promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate Slug expression |
| title_fullStr |
NatD promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate Slug expression |
| title_full_unstemmed |
NatD promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate Slug expression |
| title_sort |
natd promotes lung cancer progression by preventing histone h4 serine phosphorylation to activate slug expression |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/6a59395fcee24917b56f36386d89135b |
| work_keys_str_mv |
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