Altered Intrinsic Functional Connectivity of the Primary Visual Cortex in Patients with Corneal Ulcer: A Resting-State fMRI Study
Shou-Long Hu,1,2,* Li-Ying Tang,3,* Jian-Wen Fang,2,* Ting Su,3 Qian-Min Ge,2 Qi Lin,2 Biao Li,2 Wen-Qing Shi,2 Qiu-Yu Li,2 Rong-Bin Liang,2 Yi Shao2 1National Center for Children’s Health, MOE Key Laboratory of Major Diseases in Children, Department of Ophthalmology, Beijing Children&...
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Dove Medical Press
2020
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oai:doaj.org-article:6a5a11fe385e4d62bee6c462d9d55c172021-12-02T13:14:20ZAltered Intrinsic Functional Connectivity of the Primary Visual Cortex in Patients with Corneal Ulcer: A Resting-State fMRI Study1178-2021https://doaj.org/article/6a5a11fe385e4d62bee6c462d9d55c172020-06-01T00:00:00Zhttps://www.dovepress.com/-altered-intrinsic-functional-connectivity-of-the-primary-visual-cort-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Shou-Long Hu,1,2,* Li-Ying Tang,3,* Jian-Wen Fang,2,* Ting Su,3 Qian-Min Ge,2 Qi Lin,2 Biao Li,2 Wen-Qing Shi,2 Qiu-Yu Li,2 Rong-Bin Liang,2 Yi Shao2 1National Center for Children’s Health, MOE Key Laboratory of Major Diseases in Children, Department of Ophthalmology, Beijing Children’s Hospital, Capital Medical University, Beijing 100045, People’s Republic of China; 2Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, Nanchang 330006, Jiangxi, People’s Republic of China; 3Department of Ophthalmology, Xiang’an Hospital of Xiamen University; Fujian Provincial Key Laboratory of Ophthalmology and Visual Science; Eye Institute of Xiamen University; Xiamen University School of Medicine, Xiamen 361102, Fujian Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yi Shao Email freebee99@163.comPurpose: To investigate differences in the functional connectivity (FC) of the primary visual cortex between patients with corneal ulcer (CU) and healthy controls (HCs) using resting-state functional magnetic resonance imaging.Patients and Methods: A total of 30 patients with CU and 30 HCs were closely matched in terms of sex, age, and level of education. Two-sample t-test, receiver operating characteristic curve, and Pearson’s correlation coefficient analyses were used to determine the differences in FC between the two groups, the mean FC value of patients with CU and HCs, and the correlation between FC signal values and clinical manifestations in different brain regions of patients.Results: The CU group showed significantly elevated FC in the left and right middle frontal gyri and lower FC with the right cuneus compared with the HC group. In addition, the FC of the right cingulate and left superior frontal gyri also increased in the CU group. The receiver operating characteristic curve revealed high diagnostic value in those brain regions.Conclusion: CU involves aberrant FC of the primary visual cortex in different brain areas, including visual-related and cognitive-related regions. This finding may unveil the underlying neural mechanisms of impaired visual function in CU.Keywords: corneal ulcer, functional magnetic resonance imaging, resting state, spontaneous brain activity, primary visual cortexHu SLTang LYFang JWSu TGe QMLin QLi BShi WQLi QYLiang RBShao YDove Medical Pressarticlecorneal ulcerfunctional magnetic resonance imagingresting statespontaneous brain activityprimary visual cortexNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 1571-1581 (2020) |
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corneal ulcer functional magnetic resonance imaging resting state spontaneous brain activity primary visual cortex Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
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corneal ulcer functional magnetic resonance imaging resting state spontaneous brain activity primary visual cortex Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Hu SL Tang LY Fang JW Su T Ge QM Lin Q Li B Shi WQ Li QY Liang RB Shao Y Altered Intrinsic Functional Connectivity of the Primary Visual Cortex in Patients with Corneal Ulcer: A Resting-State fMRI Study |
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Shou-Long Hu,1,2,* Li-Ying Tang,3,* Jian-Wen Fang,2,* Ting Su,3 Qian-Min Ge,2 Qi Lin,2 Biao Li,2 Wen-Qing Shi,2 Qiu-Yu Li,2 Rong-Bin Liang,2 Yi Shao2 1National Center for Children’s Health, MOE Key Laboratory of Major Diseases in Children, Department of Ophthalmology, Beijing Children’s Hospital, Capital Medical University, Beijing 100045, People’s Republic of China; 2Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, Nanchang 330006, Jiangxi, People’s Republic of China; 3Department of Ophthalmology, Xiang’an Hospital of Xiamen University; Fujian Provincial Key Laboratory of Ophthalmology and Visual Science; Eye Institute of Xiamen University; Xiamen University School of Medicine, Xiamen 361102, Fujian Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yi Shao Email freebee99@163.comPurpose: To investigate differences in the functional connectivity (FC) of the primary visual cortex between patients with corneal ulcer (CU) and healthy controls (HCs) using resting-state functional magnetic resonance imaging.Patients and Methods: A total of 30 patients with CU and 30 HCs were closely matched in terms of sex, age, and level of education. Two-sample t-test, receiver operating characteristic curve, and Pearson’s correlation coefficient analyses were used to determine the differences in FC between the two groups, the mean FC value of patients with CU and HCs, and the correlation between FC signal values and clinical manifestations in different brain regions of patients.Results: The CU group showed significantly elevated FC in the left and right middle frontal gyri and lower FC with the right cuneus compared with the HC group. In addition, the FC of the right cingulate and left superior frontal gyri also increased in the CU group. The receiver operating characteristic curve revealed high diagnostic value in those brain regions.Conclusion: CU involves aberrant FC of the primary visual cortex in different brain areas, including visual-related and cognitive-related regions. This finding may unveil the underlying neural mechanisms of impaired visual function in CU.Keywords: corneal ulcer, functional magnetic resonance imaging, resting state, spontaneous brain activity, primary visual cortex |
format |
article |
author |
Hu SL Tang LY Fang JW Su T Ge QM Lin Q Li B Shi WQ Li QY Liang RB Shao Y |
author_facet |
Hu SL Tang LY Fang JW Su T Ge QM Lin Q Li B Shi WQ Li QY Liang RB Shao Y |
author_sort |
Hu SL |
title |
Altered Intrinsic Functional Connectivity of the Primary Visual Cortex in Patients with Corneal Ulcer: A Resting-State fMRI Study |
title_short |
Altered Intrinsic Functional Connectivity of the Primary Visual Cortex in Patients with Corneal Ulcer: A Resting-State fMRI Study |
title_full |
Altered Intrinsic Functional Connectivity of the Primary Visual Cortex in Patients with Corneal Ulcer: A Resting-State fMRI Study |
title_fullStr |
Altered Intrinsic Functional Connectivity of the Primary Visual Cortex in Patients with Corneal Ulcer: A Resting-State fMRI Study |
title_full_unstemmed |
Altered Intrinsic Functional Connectivity of the Primary Visual Cortex in Patients with Corneal Ulcer: A Resting-State fMRI Study |
title_sort |
altered intrinsic functional connectivity of the primary visual cortex in patients with corneal ulcer: a resting-state fmri study |
publisher |
Dove Medical Press |
publishDate |
2020 |
url |
https://doaj.org/article/6a5a11fe385e4d62bee6c462d9d55c17 |
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