Attenuation of oxidative damage-associated hepatotoxicity by piperine in CCl4-induced liver fibrosis

Objectives: The present research has demonstrated the impact of treatment with piperine on hepatic fibrosis induced by the administration of carbon tetrachloride. Methods: In order to study the outcome of piperine treatment on hepatic fibrosis caused by carbon tetrachloride administration in male Wi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Adil Farooq Wali, Shafat Ali, Summya Rashid, Rana M. Alsaffar, Azher Arafah, Wajhul Qamar, Ajaz Ahmad, Bilal Ahmad Paray, Sheikh Bilal Ahmad, Bashayr M. Alsuwayni, Muneeb U. Rehman
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Fibrosis Hepatotoxicity Piperine Carbon tetrachloride Proinflammatory markers Science (General) Q1-390
Acceso en línea:	https://doaj.org/article/6a5a46190c5d4a32a2067d3b66a2c57b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6a5a46190c5d4a32a2067d3b66a2c57b
record_format	dspace
spelling	oai:doaj.org-article:6a5a46190c5d4a32a2067d3b66a2c57b2021-11-18T04:44:12ZAttenuation of oxidative damage-associated hepatotoxicity by piperine in CCl4-induced liver fibrosis1018-364710.1016/j.jksus.2021.101629https://doaj.org/article/6a5a46190c5d4a32a2067d3b66a2c57b2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1018364721002913https://doaj.org/toc/1018-3647Objectives: The present research has demonstrated the impact of treatment with piperine on hepatic fibrosis induced by the administration of carbon tetrachloride. Methods: In order to study the outcome of piperine treatment on hepatic fibrosis caused by carbon tetrachloride administration in male Wistar rats, a total of 24 rats were collected and randomly classified into 4 separate groups each consisting of 6 animals. Group I was assigned as a control group and treated with olive oil for 4 weeks (1 ml/kg, i.p.) with two doses each week. Group II was designated as a toxic group and treated with carbon tetrachloride for 4 weeks (1 ml/kg, 1:1 combination with olive oil, i.p.) with two hepatic fibrosis induction doses each week. Group III was graded as a group I therapy and co-treated with carbon tetrachloride (1 ml/kg, 1:1 combination with olive oil, i.p.) for 4 weeks with two hepatic fibrosis induction doses a week and with piperine (25 mg/kg) for 4 weeks. Group IV was designated as group II therapy and co-treated with carbon tetrachloride (1 ml/kg, 1:1 combination of olive oil, i.p.) for 4 weeks with two hepatic fibrosis induction doses a week and piperine (50 mg/kg) for 4 weeks. Results: Piperine significantly reduced the carbon tetrachloride augmented activities of liver enzymes, lipid peroxidation, glutathione, hydroxyproline, nitrite, and carbonyl levels. Carbon tetrachloride enhanced Total cholesterol (TC), Triglyceride (TG), Low density lipoprotein (LDL), and Very low density lipoprotein (VLDL) levels, and decreased High density lipoprotein (HDL) level was restored to normal with piperine treatment. Moreover, piperine inhibited the over-expression of pro-inflammatory biomarkers and α-SMA. Conclusion: The data of the current study demonstrated piperine as a potent hepato-protective agent and recommends the use of piperine for preventing hepatic fibrosis.Adil Farooq WaliShafat AliSummya RashidRana M. AlsaffarAzher ArafahWajhul QamarAjaz AhmadBilal Ahmad ParaySheikh Bilal AhmadBashayr M. AlsuwayniMuneeb U. RehmanElsevierarticleFibrosisHepatotoxicityPiperineCarbon tetrachlorideProinflammatory markersScience (General)Q1-390ENJournal of King Saud University: Science, Vol 33, Iss 8, Pp 101629- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Fibrosis Hepatotoxicity Piperine Carbon tetrachloride Proinflammatory markers Science (General) Q1-390
spellingShingle	Fibrosis Hepatotoxicity Piperine Carbon tetrachloride Proinflammatory markers Science (General) Q1-390 Adil Farooq Wali Shafat Ali Summya Rashid Rana M. Alsaffar Azher Arafah Wajhul Qamar Ajaz Ahmad Bilal Ahmad Paray Sheikh Bilal Ahmad Bashayr M. Alsuwayni Muneeb U. Rehman Attenuation of oxidative damage-associated hepatotoxicity by piperine in CCl4-induced liver fibrosis
description	Objectives: The present research has demonstrated the impact of treatment with piperine on hepatic fibrosis induced by the administration of carbon tetrachloride. Methods: In order to study the outcome of piperine treatment on hepatic fibrosis caused by carbon tetrachloride administration in male Wistar rats, a total of 24 rats were collected and randomly classified into 4 separate groups each consisting of 6 animals. Group I was assigned as a control group and treated with olive oil for 4 weeks (1 ml/kg, i.p.) with two doses each week. Group II was designated as a toxic group and treated with carbon tetrachloride for 4 weeks (1 ml/kg, 1:1 combination with olive oil, i.p.) with two hepatic fibrosis induction doses each week. Group III was graded as a group I therapy and co-treated with carbon tetrachloride (1 ml/kg, 1:1 combination with olive oil, i.p.) for 4 weeks with two hepatic fibrosis induction doses a week and with piperine (25 mg/kg) for 4 weeks. Group IV was designated as group II therapy and co-treated with carbon tetrachloride (1 ml/kg, 1:1 combination of olive oil, i.p.) for 4 weeks with two hepatic fibrosis induction doses a week and piperine (50 mg/kg) for 4 weeks. Results: Piperine significantly reduced the carbon tetrachloride augmented activities of liver enzymes, lipid peroxidation, glutathione, hydroxyproline, nitrite, and carbonyl levels. Carbon tetrachloride enhanced Total cholesterol (TC), Triglyceride (TG), Low density lipoprotein (LDL), and Very low density lipoprotein (VLDL) levels, and decreased High density lipoprotein (HDL) level was restored to normal with piperine treatment. Moreover, piperine inhibited the over-expression of pro-inflammatory biomarkers and α-SMA. Conclusion: The data of the current study demonstrated piperine as a potent hepato-protective agent and recommends the use of piperine for preventing hepatic fibrosis.
format	article
author	Adil Farooq Wali Shafat Ali Summya Rashid Rana M. Alsaffar Azher Arafah Wajhul Qamar Ajaz Ahmad Bilal Ahmad Paray Sheikh Bilal Ahmad Bashayr M. Alsuwayni Muneeb U. Rehman
author_facet	Adil Farooq Wali Shafat Ali Summya Rashid Rana M. Alsaffar Azher Arafah Wajhul Qamar Ajaz Ahmad Bilal Ahmad Paray Sheikh Bilal Ahmad Bashayr M. Alsuwayni Muneeb U. Rehman
author_sort	Adil Farooq Wali
title	Attenuation of oxidative damage-associated hepatotoxicity by piperine in CCl4-induced liver fibrosis
title_short	Attenuation of oxidative damage-associated hepatotoxicity by piperine in CCl4-induced liver fibrosis
title_full	Attenuation of oxidative damage-associated hepatotoxicity by piperine in CCl4-induced liver fibrosis
title_fullStr	Attenuation of oxidative damage-associated hepatotoxicity by piperine in CCl4-induced liver fibrosis
title_full_unstemmed	Attenuation of oxidative damage-associated hepatotoxicity by piperine in CCl4-induced liver fibrosis
title_sort	attenuation of oxidative damage-associated hepatotoxicity by piperine in ccl4-induced liver fibrosis
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/6a5a46190c5d4a32a2067d3b66a2c57b
work_keys_str_mv	AT adilfarooqwali attenuationofoxidativedamageassociatedhepatotoxicitybypiperineinccl4inducedliverfibrosis AT shafatali attenuationofoxidativedamageassociatedhepatotoxicitybypiperineinccl4inducedliverfibrosis AT summyarashid attenuationofoxidativedamageassociatedhepatotoxicitybypiperineinccl4inducedliverfibrosis AT ranamalsaffar attenuationofoxidativedamageassociatedhepatotoxicitybypiperineinccl4inducedliverfibrosis AT azherarafah attenuationofoxidativedamageassociatedhepatotoxicitybypiperineinccl4inducedliverfibrosis AT wajhulqamar attenuationofoxidativedamageassociatedhepatotoxicitybypiperineinccl4inducedliverfibrosis AT ajazahmad attenuationofoxidativedamageassociatedhepatotoxicitybypiperineinccl4inducedliverfibrosis AT bilalahmadparay attenuationofoxidativedamageassociatedhepatotoxicitybypiperineinccl4inducedliverfibrosis AT sheikhbilalahmad attenuationofoxidativedamageassociatedhepatotoxicitybypiperineinccl4inducedliverfibrosis AT bashayrmalsuwayni attenuationofoxidativedamageassociatedhepatotoxicitybypiperineinccl4inducedliverfibrosis AT muneeburehman attenuationofoxidativedamageassociatedhepatotoxicitybypiperineinccl4inducedliverfibrosis
_version_	1718425105762091008

Attenuation of oxidative damage-associated hepatotoxicity by piperine in CCl4-induced liver fibrosis

Ejemplares similares