HIF1α regulates glioma chemosensitivity through the transformation between differentiation and dedifferentiation in various oxygen levels

Abstract Chemotherapy plays a significant role in glioma treatment; however, it has limited effectiveness in extending the life expectancies of glioma patients. Traditional studies have attributed this lack of efficacy to glioma stem cells (GSCs) and their high resistance to chemotherapy, and hypoxi...

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Autores principales:	Pan Wang, Wenwu Wan, Shuanglong Xiong, Junwei Wang, Dewei Zou, Chuan Lan, Shuangjiang Yu, Bin Liao, Hua Feng, Nan Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6a5b57193964410488125334d895996d
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spelling	oai:doaj.org-article:6a5b57193964410488125334d895996d2021-12-02T15:05:41ZHIF1α regulates glioma chemosensitivity through the transformation between differentiation and dedifferentiation in various oxygen levels10.1038/s41598-017-06086-22045-2322https://doaj.org/article/6a5b57193964410488125334d895996d2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06086-2https://doaj.org/toc/2045-2322Abstract Chemotherapy plays a significant role in glioma treatment; however, it has limited effectiveness in extending the life expectancies of glioma patients. Traditional studies have attributed this lack of efficacy to glioma stem cells (GSCs) and their high resistance to chemotherapy, and hypoxia worsens this issue. In contrast, hyperoxia effectively alleviates hypoxia in glioma and sensitizes glioma cells to chemotherapy. In a summary of traditional studies, the majority of researchers overlooked the influence of hypoxia on differentiated cells because they only focused on the maintenance of GSCs stemness, which thus resulted in chemoresistance. Because of this background, we hypothesized that GSCs may be induced through dedifferentiation under hypoxic conditions, and hypoxia maintains GSCs stemness, which thus leads to resistance to chemotherapy. In contrast, hyperoxia inhibits the dedifferentiation process and promotes GSCs differentiation, which increases the sensitization of glioma cells to chemotherapy. Hypoxia-inducible factor-1α (HIF1α) contributes substantially to the stemness maintenance of GSCs and resistance of glioma to chemotherapy; thus, we investigated whether HIF1α regulates the resistance or sensitization of glioma cells to chemotherapy in different oxygen levels. It highlights a novel viewpoint on glioma chemosensitivity from the transformation between dedifferentiation and differentiation in different oxygen levels.Pan WangWenwu WanShuanglong XiongJunwei WangDewei ZouChuan LanShuangjiang YuBin LiaoHua FengNan WuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pan Wang Wenwu Wan Shuanglong Xiong Junwei Wang Dewei Zou Chuan Lan Shuangjiang Yu Bin Liao Hua Feng Nan Wu HIF1α regulates glioma chemosensitivity through the transformation between differentiation and dedifferentiation in various oxygen levels
description	Abstract Chemotherapy plays a significant role in glioma treatment; however, it has limited effectiveness in extending the life expectancies of glioma patients. Traditional studies have attributed this lack of efficacy to glioma stem cells (GSCs) and their high resistance to chemotherapy, and hypoxia worsens this issue. In contrast, hyperoxia effectively alleviates hypoxia in glioma and sensitizes glioma cells to chemotherapy. In a summary of traditional studies, the majority of researchers overlooked the influence of hypoxia on differentiated cells because they only focused on the maintenance of GSCs stemness, which thus resulted in chemoresistance. Because of this background, we hypothesized that GSCs may be induced through dedifferentiation under hypoxic conditions, and hypoxia maintains GSCs stemness, which thus leads to resistance to chemotherapy. In contrast, hyperoxia inhibits the dedifferentiation process and promotes GSCs differentiation, which increases the sensitization of glioma cells to chemotherapy. Hypoxia-inducible factor-1α (HIF1α) contributes substantially to the stemness maintenance of GSCs and resistance of glioma to chemotherapy; thus, we investigated whether HIF1α regulates the resistance or sensitization of glioma cells to chemotherapy in different oxygen levels. It highlights a novel viewpoint on glioma chemosensitivity from the transformation between dedifferentiation and differentiation in different oxygen levels.
format	article
author	Pan Wang Wenwu Wan Shuanglong Xiong Junwei Wang Dewei Zou Chuan Lan Shuangjiang Yu Bin Liao Hua Feng Nan Wu
author_facet	Pan Wang Wenwu Wan Shuanglong Xiong Junwei Wang Dewei Zou Chuan Lan Shuangjiang Yu Bin Liao Hua Feng Nan Wu
author_sort	Pan Wang
title	HIF1α regulates glioma chemosensitivity through the transformation between differentiation and dedifferentiation in various oxygen levels
title_short	HIF1α regulates glioma chemosensitivity through the transformation between differentiation and dedifferentiation in various oxygen levels
title_full	HIF1α regulates glioma chemosensitivity through the transformation between differentiation and dedifferentiation in various oxygen levels
title_fullStr	HIF1α regulates glioma chemosensitivity through the transformation between differentiation and dedifferentiation in various oxygen levels
title_full_unstemmed	HIF1α regulates glioma chemosensitivity through the transformation between differentiation and dedifferentiation in various oxygen levels
title_sort	hif1α regulates glioma chemosensitivity through the transformation between differentiation and dedifferentiation in various oxygen levels
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6a5b57193964410488125334d895996d
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HIF1α regulates glioma chemosensitivity through the transformation between differentiation and dedifferentiation in various oxygen levels

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