FMR1 genotype with autoimmunity-associated polycystic ovary-like phenotype and decreased pregnancy chance.

The FMR1 gene partially appears to control ovarian reserve, with a specific ovarian sub-genotype statistically associated with a polycystic ovary (PCO)- like phenotype. Some forms of PCO have been associated with autoimmunity. We, therefore, investigated in multiple regression analyses associations...

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Autores principales:	Norbert Gleicher, Andrea Weghofer, Irene H Lee, David H Barad
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6a5ce08fe5a94b0aaf62b1c1fc0fc702
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spelling	oai:doaj.org-article:6a5ce08fe5a94b0aaf62b1c1fc0fc7022021-11-18T07:01:37ZFMR1 genotype with autoimmunity-associated polycystic ovary-like phenotype and decreased pregnancy chance.1932-620310.1371/journal.pone.0015303https://doaj.org/article/6a5ce08fe5a94b0aaf62b1c1fc0fc7022010-12-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21179569/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The FMR1 gene partially appears to control ovarian reserve, with a specific ovarian sub-genotype statistically associated with a polycystic ovary (PCO)- like phenotype. Some forms of PCO have been associated with autoimmunity. We, therefore, investigated in multiple regression analyses associations of ovary-specific FMR1 genotypes with autoimmunity and pregnancy chances (with in vitro fertilization, IVF) in 339 consecutive infertile women (455 IVF cycles), 75 with PCO-like phenotype, adjusted for age, race/ethnicity, medication dosage and number of oocytes retrieved. Patients included 183 (54.0%) with normal (norm) and 156 (46%) with heterozygous (het) FMR1 genotypes; 133 (39.2%) demonstrated laboratory evidence of autoimmunity: 51.1% of het-norm/low, 38.3% of norm and 24.2% het-norm/high genotype and sub-genotypes demonstrated autoimmunity (p=0.003). Prevalence of autoimmunity increased further in PCO-like phenotype patients with het-norm/low genotype (83.3%), remained unchanged with norm (34.0%) and decreased in het-norm/high women (10.0%; P<0.0001). Pregnancy rates were significantly higher with norm (38.6%) than het-norm/low (22.2%, p=0.001). FMR1 sub-genotype het-norm/low is strongly associated with autoimmunity and decreased pregnancy chances in IVF, reaffirming the importance of the distal long arm of the X chromosome (FMR1 maps at Xq27.3) for autoimmunity, ovarian function and, likely, pregnancy chance with IVF.Norbert GleicherAndrea WeghoferIrene H LeeDavid H BaradPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 12, p e15303 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Norbert Gleicher Andrea Weghofer Irene H Lee David H Barad FMR1 genotype with autoimmunity-associated polycystic ovary-like phenotype and decreased pregnancy chance.
description	The FMR1 gene partially appears to control ovarian reserve, with a specific ovarian sub-genotype statistically associated with a polycystic ovary (PCO)- like phenotype. Some forms of PCO have been associated with autoimmunity. We, therefore, investigated in multiple regression analyses associations of ovary-specific FMR1 genotypes with autoimmunity and pregnancy chances (with in vitro fertilization, IVF) in 339 consecutive infertile women (455 IVF cycles), 75 with PCO-like phenotype, adjusted for age, race/ethnicity, medication dosage and number of oocytes retrieved. Patients included 183 (54.0%) with normal (norm) and 156 (46%) with heterozygous (het) FMR1 genotypes; 133 (39.2%) demonstrated laboratory evidence of autoimmunity: 51.1% of het-norm/low, 38.3% of norm and 24.2% het-norm/high genotype and sub-genotypes demonstrated autoimmunity (p=0.003). Prevalence of autoimmunity increased further in PCO-like phenotype patients with het-norm/low genotype (83.3%), remained unchanged with norm (34.0%) and decreased in het-norm/high women (10.0%; P<0.0001). Pregnancy rates were significantly higher with norm (38.6%) than het-norm/low (22.2%, p=0.001). FMR1 sub-genotype het-norm/low is strongly associated with autoimmunity and decreased pregnancy chances in IVF, reaffirming the importance of the distal long arm of the X chromosome (FMR1 maps at Xq27.3) for autoimmunity, ovarian function and, likely, pregnancy chance with IVF.
format	article
author	Norbert Gleicher Andrea Weghofer Irene H Lee David H Barad
author_facet	Norbert Gleicher Andrea Weghofer Irene H Lee David H Barad
author_sort	Norbert Gleicher
title	FMR1 genotype with autoimmunity-associated polycystic ovary-like phenotype and decreased pregnancy chance.
title_short	FMR1 genotype with autoimmunity-associated polycystic ovary-like phenotype and decreased pregnancy chance.
title_full	FMR1 genotype with autoimmunity-associated polycystic ovary-like phenotype and decreased pregnancy chance.
title_fullStr	FMR1 genotype with autoimmunity-associated polycystic ovary-like phenotype and decreased pregnancy chance.
title_full_unstemmed	FMR1 genotype with autoimmunity-associated polycystic ovary-like phenotype and decreased pregnancy chance.
title_sort	fmr1 genotype with autoimmunity-associated polycystic ovary-like phenotype and decreased pregnancy chance.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/6a5ce08fe5a94b0aaf62b1c1fc0fc702
work_keys_str_mv	AT norbertgleicher fmr1genotypewithautoimmunityassociatedpolycysticovarylikephenotypeanddecreasedpregnancychance AT andreaweghofer fmr1genotypewithautoimmunityassociatedpolycysticovarylikephenotypeanddecreasedpregnancychance AT irenehlee fmr1genotypewithautoimmunityassociatedpolycysticovarylikephenotypeanddecreasedpregnancychance AT davidhbarad fmr1genotypewithautoimmunityassociatedpolycysticovarylikephenotypeanddecreasedpregnancychance
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FMR1 genotype with autoimmunity-associated polycystic ovary-like phenotype and decreased pregnancy chance.

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