Research Progress on the Ability of Astragaloside IV to Protect the Brain Against Ischemia-Reperfusion Injury

Stroke, a disease with a sudden onset and high morbidity and mortality rates, is difficult to treat in the clinic. Traditional Chinese medicine has become increasingly widely used in clinical practice. Modern pharmacological studies have found that Radix Astragali has a variety of medicinal properti...

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Autores principales:	Xianhui Kang, Shuyue Su, Wandong Hong, Wujun Geng, Hongli Tang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Radix Astragali astragaloside-IV stroke cerebral protection ischemia reperfusion Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/6a5e5b66a4c74a448aa8945a16bfca36
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spelling	oai:doaj.org-article:6a5e5b66a4c74a448aa8945a16bfca362021-11-16T07:46:51ZResearch Progress on the Ability of Astragaloside IV to Protect the Brain Against Ischemia-Reperfusion Injury1662-453X10.3389/fnins.2021.755902https://doaj.org/article/6a5e5b66a4c74a448aa8945a16bfca362021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnins.2021.755902/fullhttps://doaj.org/toc/1662-453XStroke, a disease with a sudden onset and high morbidity and mortality rates, is difficult to treat in the clinic. Traditional Chinese medicine has become increasingly widely used in clinical practice. Modern pharmacological studies have found that Radix Astragali has a variety of medicinal properties, i.e., immunoregulatory, antioxidative, anti-cancer, anti-diabetes, myocardial protective, hepatoprotective, and antiviral functions. This article reviews the protective effect and mechanism of astragaloside IV, which is extracted from Radix Astragali, on stroke, discusses the cerebroprotective effect of astragaloside IV against ischemia-reperfusion-related complications, offers insight into research prospects, and expands the idea of integrating traditional Chinese and Western medicine treatment strategies and drugs to provide a theoretical reference for the clinical treatment of cerebral ischemia-reperfusion injury and the improvement of stroke prognosis.Xianhui KangXianhui KangShuyue SuWandong HongWujun GengWujun GengHongli TangFrontiers Media S.A.articleRadix Astragaliastragaloside-IVstrokecerebral protectionischemia reperfusionNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Radix Astragali astragaloside-IV stroke cerebral protection ischemia reperfusion Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Radix Astragali astragaloside-IV stroke cerebral protection ischemia reperfusion Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Xianhui Kang Xianhui Kang Shuyue Su Wandong Hong Wujun Geng Wujun Geng Hongli Tang Research Progress on the Ability of Astragaloside IV to Protect the Brain Against Ischemia-Reperfusion Injury
description	Stroke, a disease with a sudden onset and high morbidity and mortality rates, is difficult to treat in the clinic. Traditional Chinese medicine has become increasingly widely used in clinical practice. Modern pharmacological studies have found that Radix Astragali has a variety of medicinal properties, i.e., immunoregulatory, antioxidative, anti-cancer, anti-diabetes, myocardial protective, hepatoprotective, and antiviral functions. This article reviews the protective effect and mechanism of astragaloside IV, which is extracted from Radix Astragali, on stroke, discusses the cerebroprotective effect of astragaloside IV against ischemia-reperfusion-related complications, offers insight into research prospects, and expands the idea of integrating traditional Chinese and Western medicine treatment strategies and drugs to provide a theoretical reference for the clinical treatment of cerebral ischemia-reperfusion injury and the improvement of stroke prognosis.
format	article
author	Xianhui Kang Xianhui Kang Shuyue Su Wandong Hong Wujun Geng Wujun Geng Hongli Tang
author_facet	Xianhui Kang Xianhui Kang Shuyue Su Wandong Hong Wujun Geng Wujun Geng Hongli Tang
author_sort	Xianhui Kang
title	Research Progress on the Ability of Astragaloside IV to Protect the Brain Against Ischemia-Reperfusion Injury
title_short	Research Progress on the Ability of Astragaloside IV to Protect the Brain Against Ischemia-Reperfusion Injury
title_full	Research Progress on the Ability of Astragaloside IV to Protect the Brain Against Ischemia-Reperfusion Injury
title_fullStr	Research Progress on the Ability of Astragaloside IV to Protect the Brain Against Ischemia-Reperfusion Injury
title_full_unstemmed	Research Progress on the Ability of Astragaloside IV to Protect the Brain Against Ischemia-Reperfusion Injury
title_sort	research progress on the ability of astragaloside iv to protect the brain against ischemia-reperfusion injury
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/6a5e5b66a4c74a448aa8945a16bfca36
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Research Progress on the Ability of Astragaloside IV to Protect the Brain Against Ischemia-Reperfusion Injury

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