Targeting Bacterial Gyrase with Cystobactamid, Fluoroquinolone, and Aminocoumarin Antibiotics Induces Distinct Molecular Signatures in Pseudomonas aeruginosa

Novel antibiotics are urgently needed to tackle the growing worldwide problem of antimicrobial resistance. Bacterial pathogens possess few privileged targets for a successful therapy: the majority of existing antibiotics as well as current candidates in development target the complex bacterial mach...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Raimo Franke, Heike Overwin, Susanne Häussler, Mark Brönstrup
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/6a607938d1524a0f9610a31caf9103cb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6a607938d1524a0f9610a31caf9103cb
record_format	dspace
spelling	oai:doaj.org-article:6a607938d1524a0f9610a31caf9103cb2021-12-02T17:49:15ZTargeting Bacterial Gyrase with Cystobactamid, Fluoroquinolone, and Aminocoumarin Antibiotics Induces Distinct Molecular Signatures in Pseudomonas aeruginosa2379-507710.1128/mSystems.00610-21https://doaj.org/article/6a607938d1524a0f9610a31caf9103cb2021-08-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00610-21https://doaj.org/toc/2379-5077 Novel antibiotics are urgently needed to tackle the growing worldwide problem of antimicrobial resistance. Bacterial pathogens possess few privileged targets for a successful therapy: the majority of existing antibiotics as well as current candidates in development target the complex bacterial machinery for cell wall synthesis, protein synthesis, or DNA replication.Raimo FrankeHeike OverwinSusanne HäusslerMark BrönstrupAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmSystems, Vol 6, Iss 4 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Raimo Franke Heike Overwin Susanne Häussler Mark Brönstrup Targeting Bacterial Gyrase with Cystobactamid, Fluoroquinolone, and Aminocoumarin Antibiotics Induces Distinct Molecular Signatures in Pseudomonas aeruginosa
description	Novel antibiotics are urgently needed to tackle the growing worldwide problem of antimicrobial resistance. Bacterial pathogens possess few privileged targets for a successful therapy: the majority of existing antibiotics as well as current candidates in development target the complex bacterial machinery for cell wall synthesis, protein synthesis, or DNA replication.
format	article
author	Raimo Franke Heike Overwin Susanne Häussler Mark Brönstrup
author_facet	Raimo Franke Heike Overwin Susanne Häussler Mark Brönstrup
author_sort	Raimo Franke
title	Targeting Bacterial Gyrase with Cystobactamid, Fluoroquinolone, and Aminocoumarin Antibiotics Induces Distinct Molecular Signatures in Pseudomonas aeruginosa
title_short	Targeting Bacterial Gyrase with Cystobactamid, Fluoroquinolone, and Aminocoumarin Antibiotics Induces Distinct Molecular Signatures in Pseudomonas aeruginosa
title_full	Targeting Bacterial Gyrase with Cystobactamid, Fluoroquinolone, and Aminocoumarin Antibiotics Induces Distinct Molecular Signatures in Pseudomonas aeruginosa
title_fullStr	Targeting Bacterial Gyrase with Cystobactamid, Fluoroquinolone, and Aminocoumarin Antibiotics Induces Distinct Molecular Signatures in Pseudomonas aeruginosa
title_full_unstemmed	Targeting Bacterial Gyrase with Cystobactamid, Fluoroquinolone, and Aminocoumarin Antibiotics Induces Distinct Molecular Signatures in Pseudomonas aeruginosa
title_sort	targeting bacterial gyrase with cystobactamid, fluoroquinolone, and aminocoumarin antibiotics induces distinct molecular signatures in pseudomonas aeruginosa
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/6a607938d1524a0f9610a31caf9103cb
work_keys_str_mv	AT raimofranke targetingbacterialgyrasewithcystobactamidfluoroquinoloneandaminocoumarinantibioticsinducesdistinctmolecularsignaturesinpseudomonasaeruginosa AT heikeoverwin targetingbacterialgyrasewithcystobactamidfluoroquinoloneandaminocoumarinantibioticsinducesdistinctmolecularsignaturesinpseudomonasaeruginosa AT susannehaussler targetingbacterialgyrasewithcystobactamidfluoroquinoloneandaminocoumarinantibioticsinducesdistinctmolecularsignaturesinpseudomonasaeruginosa AT markbronstrup targetingbacterialgyrasewithcystobactamidfluoroquinoloneandaminocoumarinantibioticsinducesdistinctmolecularsignaturesinpseudomonasaeruginosa
_version_	1718379412772093952

Targeting Bacterial Gyrase with Cystobactamid, Fluoroquinolone, and Aminocoumarin Antibiotics Induces Distinct Molecular Signatures in Pseudomonas aeruginosa

Ejemplares similares