Calcium-activated potassium current modulates ventricular repolarization in chronic heart failure.

Calcium-activated potassium current modulates ventricular repolarization in chronic heart failure.

The role of I(KCa) in cardiac repolarization remains controversial and varies across species. The relevance of the current as a therapeutic target is therefore undefined. We examined the cellular electrophysiologic effects of I(KCa) blockade in controls, chronic heart failure (HF) and HF with sustai...

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Main Authors: Ingrid M Bonilla, Victor P Long, Pedro Vargas-Pinto, Patrick Wright, Andriy Belevych, Qing Lou, Kent Mowrey, Jae Yoo, Philip F Binkley, Vadim V Fedorov, Sandor Györke, Paulus M L Janssen, Ahmet Kilic, Peter J Mohler, Cynthia A Carnes
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2014
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/6a6220e6898943efbd5f6ac67f57f16c
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