Cortical representation of experimental periodontal pain: a functional magnetic resonance imaging study

Abstract The aim of this study was to investigate central pain representations during loading of the periodontium induced by orthodontic and occlusal stress. Nineteen healthy male volunteers (25.7 ± 2.8 years) were tested on two consecutive days: after phenotyping (questionnaires) and determination...

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Autores principales:	Angelika Maurer, Damian Verma, Annika Reddehase, Lukas Scheef, Alexander Radbruch, Ulrike Attenberger, Andreas Jäger, Henning Boecker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6a63b4dcabc6422b8b54548746b0c622
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spelling	oai:doaj.org-article:6a63b4dcabc6422b8b54548746b0c6222021-12-02T16:34:05ZCortical representation of experimental periodontal pain: a functional magnetic resonance imaging study10.1038/s41598-021-94775-42045-2322https://doaj.org/article/6a63b4dcabc6422b8b54548746b0c6222021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94775-4https://doaj.org/toc/2045-2322Abstract The aim of this study was to investigate central pain representations during loading of the periodontium induced by orthodontic and occlusal stress. Nineteen healthy male volunteers (25.7 ± 2.8 years) were tested on two consecutive days: after phenotyping (questionnaires) and determination of warmth (WPT) and heat (HPT) pain thresholds, functional magnetic resonance imaging was performed as event-related paradigm including 36 tooth clenchings of 3 s duration, alternating with rest periods varying between 20–30 s. The task was performed in absence (T1) and 24 h after placement of an elastic separator between the second bicuspid and the first molar on the right side of the lower jaw (T2). No significant changes in WPT and HPT were observed but pain ratings were significantly elevated at T2. Significantly elevated activation at T2, as compared to T1, was found in bilateral sensorimotor cortex, bilateral secondary sensory cortex, supplementary motor area, right rolandic operculum, and bilateral insula. Our data show for the first time in humans that periodontal stimulation, as tested by tooth clenching in the presence of an elastic separator, goes along with specific expressions of pain at behavioral and neuronal network levels. Findings supplement the existing neuroimaging literature on odontogenic pain.Angelika MaurerDamian VermaAnnika ReddehaseLukas ScheefAlexander RadbruchUlrike AttenbergerAndreas JägerHenning BoeckerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Angelika Maurer Damian Verma Annika Reddehase Lukas Scheef Alexander Radbruch Ulrike Attenberger Andreas Jäger Henning Boecker Cortical representation of experimental periodontal pain: a functional magnetic resonance imaging study
description	Abstract The aim of this study was to investigate central pain representations during loading of the periodontium induced by orthodontic and occlusal stress. Nineteen healthy male volunteers (25.7 ± 2.8 years) were tested on two consecutive days: after phenotyping (questionnaires) and determination of warmth (WPT) and heat (HPT) pain thresholds, functional magnetic resonance imaging was performed as event-related paradigm including 36 tooth clenchings of 3 s duration, alternating with rest periods varying between 20–30 s. The task was performed in absence (T1) and 24 h after placement of an elastic separator between the second bicuspid and the first molar on the right side of the lower jaw (T2). No significant changes in WPT and HPT were observed but pain ratings were significantly elevated at T2. Significantly elevated activation at T2, as compared to T1, was found in bilateral sensorimotor cortex, bilateral secondary sensory cortex, supplementary motor area, right rolandic operculum, and bilateral insula. Our data show for the first time in humans that periodontal stimulation, as tested by tooth clenching in the presence of an elastic separator, goes along with specific expressions of pain at behavioral and neuronal network levels. Findings supplement the existing neuroimaging literature on odontogenic pain.
format	article
author	Angelika Maurer Damian Verma Annika Reddehase Lukas Scheef Alexander Radbruch Ulrike Attenberger Andreas Jäger Henning Boecker
author_facet	Angelika Maurer Damian Verma Annika Reddehase Lukas Scheef Alexander Radbruch Ulrike Attenberger Andreas Jäger Henning Boecker
author_sort	Angelika Maurer
title	Cortical representation of experimental periodontal pain: a functional magnetic resonance imaging study
title_short	Cortical representation of experimental periodontal pain: a functional magnetic resonance imaging study
title_full	Cortical representation of experimental periodontal pain: a functional magnetic resonance imaging study
title_fullStr	Cortical representation of experimental periodontal pain: a functional magnetic resonance imaging study
title_full_unstemmed	Cortical representation of experimental periodontal pain: a functional magnetic resonance imaging study
title_sort	cortical representation of experimental periodontal pain: a functional magnetic resonance imaging study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6a63b4dcabc6422b8b54548746b0c622
work_keys_str_mv	AT angelikamaurer corticalrepresentationofexperimentalperiodontalpainafunctionalmagneticresonanceimagingstudy AT damianverma corticalrepresentationofexperimentalperiodontalpainafunctionalmagneticresonanceimagingstudy AT annikareddehase corticalrepresentationofexperimentalperiodontalpainafunctionalmagneticresonanceimagingstudy AT lukasscheef corticalrepresentationofexperimentalperiodontalpainafunctionalmagneticresonanceimagingstudy AT alexanderradbruch corticalrepresentationofexperimentalperiodontalpainafunctionalmagneticresonanceimagingstudy AT ulrikeattenberger corticalrepresentationofexperimentalperiodontalpainafunctionalmagneticresonanceimagingstudy AT andreasjager corticalrepresentationofexperimentalperiodontalpainafunctionalmagneticresonanceimagingstudy AT henningboecker corticalrepresentationofexperimentalperiodontalpainafunctionalmagneticresonanceimagingstudy
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Cortical representation of experimental periodontal pain: a functional magnetic resonance imaging study

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