Low BMI and weight loss aggravate COPD mortality in men, findings from a large prospective cohort: the JACC study

Abstract To clarify how low BMI and weight loss were associated with risk of chronic obstructive pulmonary disease (COPD) mortality, in a large prospective cohort of the general population across Japan, the Japan Collaborative Cohort Study, conducted between 1988 and 2009. A total of 45,837 male res...

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Autores principales:	Hiroo Wada, Ai Ikeda, Koutatsu Maruyama, Kazumasa Yamagishi, Peter J. Barnes, Takeshi Tanigawa, Akiko Tamakoshi, Hiroyasu Iso
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6a66e30085924bd5839833c04cdcd382
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spelling	oai:doaj.org-article:6a66e30085924bd5839833c04cdcd3822021-12-02T14:01:20ZLow BMI and weight loss aggravate COPD mortality in men, findings from a large prospective cohort: the JACC study10.1038/s41598-020-79860-42045-2322https://doaj.org/article/6a66e30085924bd5839833c04cdcd3822021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79860-4https://doaj.org/toc/2045-2322Abstract To clarify how low BMI and weight loss were associated with risk of chronic obstructive pulmonary disease (COPD) mortality, in a large prospective cohort of the general population across Japan, the Japan Collaborative Cohort Study, conducted between 1988 and 2009. A total of 45,837 male residents were observed for a median period of 19.1 years. Self-administered questionnaires, collecting information on BMI, weight loss since the age of 20, lifestyles, history of diseases, as well as records of COPD mortality, were analysed at 2019. During follow-up, 268 participants died from COPD. The multivariate-adjusted hazard ratio (95% confidence interval) of COPD mortality associated with a 1-SD increment of body mass index (BMI) was 0.48 (0.41–0.57), while for weight change from age of 20 (+ 2.0 kg) it was 0.63 (0.59–0.68). These associations were persistently observed after stratifications with smoking status, excluding those having airway symptoms in the baseline survey, and excluding early COPD deaths within 5, 10 and 15 years. Our study suggests that BMI and weight change since the age of 20 could be markers for COPD prognosis, indicated by risk of COPD mortality.Hiroo WadaAi IkedaKoutatsu MaruyamaKazumasa YamagishiPeter J. BarnesTakeshi TanigawaAkiko TamakoshiHiroyasu IsoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hiroo Wada Ai Ikeda Koutatsu Maruyama Kazumasa Yamagishi Peter J. Barnes Takeshi Tanigawa Akiko Tamakoshi Hiroyasu Iso Low BMI and weight loss aggravate COPD mortality in men, findings from a large prospective cohort: the JACC study
description	Abstract To clarify how low BMI and weight loss were associated with risk of chronic obstructive pulmonary disease (COPD) mortality, in a large prospective cohort of the general population across Japan, the Japan Collaborative Cohort Study, conducted between 1988 and 2009. A total of 45,837 male residents were observed for a median period of 19.1 years. Self-administered questionnaires, collecting information on BMI, weight loss since the age of 20, lifestyles, history of diseases, as well as records of COPD mortality, were analysed at 2019. During follow-up, 268 participants died from COPD. The multivariate-adjusted hazard ratio (95% confidence interval) of COPD mortality associated with a 1-SD increment of body mass index (BMI) was 0.48 (0.41–0.57), while for weight change from age of 20 (+ 2.0 kg) it was 0.63 (0.59–0.68). These associations were persistently observed after stratifications with smoking status, excluding those having airway symptoms in the baseline survey, and excluding early COPD deaths within 5, 10 and 15 years. Our study suggests that BMI and weight change since the age of 20 could be markers for COPD prognosis, indicated by risk of COPD mortality.
format	article
author	Hiroo Wada Ai Ikeda Koutatsu Maruyama Kazumasa Yamagishi Peter J. Barnes Takeshi Tanigawa Akiko Tamakoshi Hiroyasu Iso
author_facet	Hiroo Wada Ai Ikeda Koutatsu Maruyama Kazumasa Yamagishi Peter J. Barnes Takeshi Tanigawa Akiko Tamakoshi Hiroyasu Iso
author_sort	Hiroo Wada
title	Low BMI and weight loss aggravate COPD mortality in men, findings from a large prospective cohort: the JACC study
title_short	Low BMI and weight loss aggravate COPD mortality in men, findings from a large prospective cohort: the JACC study
title_full	Low BMI and weight loss aggravate COPD mortality in men, findings from a large prospective cohort: the JACC study
title_fullStr	Low BMI and weight loss aggravate COPD mortality in men, findings from a large prospective cohort: the JACC study
title_full_unstemmed	Low BMI and weight loss aggravate COPD mortality in men, findings from a large prospective cohort: the JACC study
title_sort	low bmi and weight loss aggravate copd mortality in men, findings from a large prospective cohort: the jacc study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6a66e30085924bd5839833c04cdcd382
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Low BMI and weight loss aggravate COPD mortality in men, findings from a large prospective cohort: the JACC study

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