Variations of Brain Functional Connectivity in Alcohol-Preferring and Non-Preferring Rats with Consecutive Alcohol Training or Acute Alcohol Administration

Alcohol addiction is regarded as a series of dynamic changes to neural circuitries. A comparison of the global network during different stages of alcohol addiction could provide an efficient way to understand the neurobiological basis of addiction. Two animal models (P-rats screened from an alcohol...

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Autores principales:	Yue Liu, Binbin Nie, Taotao Liu, Ning Zheng, Zeyuan Liu, Baoci Shan, Lihong Jiang, Anne Manyande, Xihai Li, Fuqiang Xu, Jie Wang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	alcohol-preferring rats fMRI genetic background functional connectivity resting state Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/6a670e5396984abcb64c33a3434883ac
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spelling	oai:doaj.org-article:6a670e5396984abcb64c33a3434883ac2021-11-25T16:58:04ZVariations of Brain Functional Connectivity in Alcohol-Preferring and Non-Preferring Rats with Consecutive Alcohol Training or Acute Alcohol Administration10.3390/brainsci111114742076-3425https://doaj.org/article/6a670e5396984abcb64c33a3434883ac2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3425/11/11/1474https://doaj.org/toc/2076-3425Alcohol addiction is regarded as a series of dynamic changes to neural circuitries. A comparison of the global network during different stages of alcohol addiction could provide an efficient way to understand the neurobiological basis of addiction. Two animal models (P-rats screened from an alcohol preference family, and NP-rats screened from an alcohol non-preference family) were trained for alcohol preference with a two-bottle free choice method for 4 weeks. To examine the changes in the neural response to alcohol during the development of alcohol preference and acute stimulation, different trials were studied with resting-state fMRI methods during different periods of alcohol preference. The correlation coefficients of 28 regions in the whole brain were calculated, and the results were compared for alcohol preference related to the genetic background/training association. The variety of coherence patterns was highly related to the state and development of alcohol preference. We observed significant special brain connectivity changes during alcohol preference in P-rats. The comparison between the P- and NP-rats highlighted the role of genetic background in alcohol preference. The results of this study support the alterations of the neural network connection during the formation of alcohol preference and confirm that alcohol preference is highly related to the genetic background. This study could provide an effective approach for understanding the neurobiological basis of alcohol addiction.Yue LiuBinbin NieTaotao LiuNing ZhengZeyuan LiuBaoci ShanLihong JiangAnne ManyandeXihai LiFuqiang XuJie WangMDPI AGarticlealcohol-preferring ratsfMRIgenetic backgroundfunctional connectivityresting stateNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain Sciences, Vol 11, Iss 1474, p 1474 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	alcohol-preferring rats fMRI genetic background functional connectivity resting state Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	alcohol-preferring rats fMRI genetic background functional connectivity resting state Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Yue Liu Binbin Nie Taotao Liu Ning Zheng Zeyuan Liu Baoci Shan Lihong Jiang Anne Manyande Xihai Li Fuqiang Xu Jie Wang Variations of Brain Functional Connectivity in Alcohol-Preferring and Non-Preferring Rats with Consecutive Alcohol Training or Acute Alcohol Administration
description	Alcohol addiction is regarded as a series of dynamic changes to neural circuitries. A comparison of the global network during different stages of alcohol addiction could provide an efficient way to understand the neurobiological basis of addiction. Two animal models (P-rats screened from an alcohol preference family, and NP-rats screened from an alcohol non-preference family) were trained for alcohol preference with a two-bottle free choice method for 4 weeks. To examine the changes in the neural response to alcohol during the development of alcohol preference and acute stimulation, different trials were studied with resting-state fMRI methods during different periods of alcohol preference. The correlation coefficients of 28 regions in the whole brain were calculated, and the results were compared for alcohol preference related to the genetic background/training association. The variety of coherence patterns was highly related to the state and development of alcohol preference. We observed significant special brain connectivity changes during alcohol preference in P-rats. The comparison between the P- and NP-rats highlighted the role of genetic background in alcohol preference. The results of this study support the alterations of the neural network connection during the formation of alcohol preference and confirm that alcohol preference is highly related to the genetic background. This study could provide an effective approach for understanding the neurobiological basis of alcohol addiction.
format	article
author	Yue Liu Binbin Nie Taotao Liu Ning Zheng Zeyuan Liu Baoci Shan Lihong Jiang Anne Manyande Xihai Li Fuqiang Xu Jie Wang
author_facet	Yue Liu Binbin Nie Taotao Liu Ning Zheng Zeyuan Liu Baoci Shan Lihong Jiang Anne Manyande Xihai Li Fuqiang Xu Jie Wang
author_sort	Yue Liu
title	Variations of Brain Functional Connectivity in Alcohol-Preferring and Non-Preferring Rats with Consecutive Alcohol Training or Acute Alcohol Administration
title_short	Variations of Brain Functional Connectivity in Alcohol-Preferring and Non-Preferring Rats with Consecutive Alcohol Training or Acute Alcohol Administration
title_full	Variations of Brain Functional Connectivity in Alcohol-Preferring and Non-Preferring Rats with Consecutive Alcohol Training or Acute Alcohol Administration
title_fullStr	Variations of Brain Functional Connectivity in Alcohol-Preferring and Non-Preferring Rats with Consecutive Alcohol Training or Acute Alcohol Administration
title_full_unstemmed	Variations of Brain Functional Connectivity in Alcohol-Preferring and Non-Preferring Rats with Consecutive Alcohol Training or Acute Alcohol Administration
title_sort	variations of brain functional connectivity in alcohol-preferring and non-preferring rats with consecutive alcohol training or acute alcohol administration
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6a670e5396984abcb64c33a3434883ac
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Variations of Brain Functional Connectivity in Alcohol-Preferring and Non-Preferring Rats with Consecutive Alcohol Training or Acute Alcohol Administration

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