The impact of vascular risk factors on the thickness and volume of the choroid in AMD patients

Abstract Disturbances in choroidal microcirculation may lead to the onset and progression of age-related macular degeneration (AMD). We aimed to assess changes in the choroidal volume and thickness in the macular region in AMD eyes and to investigate whether coexisting vascular risk factors alter ch...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Elżbieta Krytkowska, Aleksandra Grabowicz, Katarzyna Mozolewska-Piotrowska, Zofia Ulańczyk, Krzysztof Safranow, Anna Machalińska
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6a6824b1c4f540c2a82cee20fbe1113f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6a6824b1c4f540c2a82cee20fbe1113f
record_format	dspace
spelling	oai:doaj.org-article:6a6824b1c4f540c2a82cee20fbe1113f2021-12-02T17:56:56ZThe impact of vascular risk factors on the thickness and volume of the choroid in AMD patients10.1038/s41598-021-94676-62045-2322https://doaj.org/article/6a6824b1c4f540c2a82cee20fbe1113f2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94676-6https://doaj.org/toc/2045-2322Abstract Disturbances in choroidal microcirculation may lead to the onset and progression of age-related macular degeneration (AMD). We aimed to assess changes in the choroidal volume and thickness in the macular region in AMD eyes and to investigate whether coexisting vascular risk factors alter choroidal status. We enrolled 354 AMD patients (175 dry, 179 wet AMD) and 121 healthy controls. All participants underwent a complete ophthalmologic examination and assessment of choroidal thickness and volume. A multivariate analysis adjusted for age, sex, and smoking status revealed that wet AMD was an independent factor associated with higher average thickness of the central ring area (ATC) and average volume of the central ring area (AVC) and lower choroidal vascularity index (CVI) compared to controls (β = + 0.18, p = 0.0007, β = + 0.18, p = 0.0008, respectively) and to dry AMD (β = + 0.17, p = 0.00003 for both ATC and AVC and β = − 0.30 p < 0.0001 for CVI). ATC, AVC and average volume (AV) were lower in AMD patients with hypertension and ischaemic heart disease (IHD). The duration of hypertension was inversely correlated with ATC, AVC and AV (Rs = − 0.13, p < 0.05; Rs = − 0.12; p < 0.05, Rs = − 0.12; p < 0.05, respectively) while IHD duration negatively correlated with AV (Rs = − 0.15, p < 0.05). No such associations were observed in the control group. Our findings show that the choroidal vascular system in eyes with AMD is much more susceptible to damage in the presence than in the absence of systemic vascular disease.Elżbieta KrytkowskaAleksandra GrabowiczKatarzyna Mozolewska-PiotrowskaZofia UlańczykKrzysztof SafranowAnna MachalińskaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Elżbieta Krytkowska Aleksandra Grabowicz Katarzyna Mozolewska-Piotrowska Zofia Ulańczyk Krzysztof Safranow Anna Machalińska The impact of vascular risk factors on the thickness and volume of the choroid in AMD patients
description	Abstract Disturbances in choroidal microcirculation may lead to the onset and progression of age-related macular degeneration (AMD). We aimed to assess changes in the choroidal volume and thickness in the macular region in AMD eyes and to investigate whether coexisting vascular risk factors alter choroidal status. We enrolled 354 AMD patients (175 dry, 179 wet AMD) and 121 healthy controls. All participants underwent a complete ophthalmologic examination and assessment of choroidal thickness and volume. A multivariate analysis adjusted for age, sex, and smoking status revealed that wet AMD was an independent factor associated with higher average thickness of the central ring area (ATC) and average volume of the central ring area (AVC) and lower choroidal vascularity index (CVI) compared to controls (β = + 0.18, p = 0.0007, β = + 0.18, p = 0.0008, respectively) and to dry AMD (β = + 0.17, p = 0.00003 for both ATC and AVC and β = − 0.30 p < 0.0001 for CVI). ATC, AVC and average volume (AV) were lower in AMD patients with hypertension and ischaemic heart disease (IHD). The duration of hypertension was inversely correlated with ATC, AVC and AV (Rs = − 0.13, p < 0.05; Rs = − 0.12; p < 0.05, Rs = − 0.12; p < 0.05, respectively) while IHD duration negatively correlated with AV (Rs = − 0.15, p < 0.05). No such associations were observed in the control group. Our findings show that the choroidal vascular system in eyes with AMD is much more susceptible to damage in the presence than in the absence of systemic vascular disease.
format	article
author	Elżbieta Krytkowska Aleksandra Grabowicz Katarzyna Mozolewska-Piotrowska Zofia Ulańczyk Krzysztof Safranow Anna Machalińska
author_facet	Elżbieta Krytkowska Aleksandra Grabowicz Katarzyna Mozolewska-Piotrowska Zofia Ulańczyk Krzysztof Safranow Anna Machalińska
author_sort	Elżbieta Krytkowska
title	The impact of vascular risk factors on the thickness and volume of the choroid in AMD patients
title_short	The impact of vascular risk factors on the thickness and volume of the choroid in AMD patients
title_full	The impact of vascular risk factors on the thickness and volume of the choroid in AMD patients
title_fullStr	The impact of vascular risk factors on the thickness and volume of the choroid in AMD patients
title_full_unstemmed	The impact of vascular risk factors on the thickness and volume of the choroid in AMD patients
title_sort	impact of vascular risk factors on the thickness and volume of the choroid in amd patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6a6824b1c4f540c2a82cee20fbe1113f
work_keys_str_mv	AT elzbietakrytkowska theimpactofvascularriskfactorsonthethicknessandvolumeofthechoroidinamdpatients AT aleksandragrabowicz theimpactofvascularriskfactorsonthethicknessandvolumeofthechoroidinamdpatients AT katarzynamozolewskapiotrowska theimpactofvascularriskfactorsonthethicknessandvolumeofthechoroidinamdpatients AT zofiaulanczyk theimpactofvascularriskfactorsonthethicknessandvolumeofthechoroidinamdpatients AT krzysztofsafranow theimpactofvascularriskfactorsonthethicknessandvolumeofthechoroidinamdpatients AT annamachalinska theimpactofvascularriskfactorsonthethicknessandvolumeofthechoroidinamdpatients AT elzbietakrytkowska impactofvascularriskfactorsonthethicknessandvolumeofthechoroidinamdpatients AT aleksandragrabowicz impactofvascularriskfactorsonthethicknessandvolumeofthechoroidinamdpatients AT katarzynamozolewskapiotrowska impactofvascularriskfactorsonthethicknessandvolumeofthechoroidinamdpatients AT zofiaulanczyk impactofvascularriskfactorsonthethicknessandvolumeofthechoroidinamdpatients AT krzysztofsafranow impactofvascularriskfactorsonthethicknessandvolumeofthechoroidinamdpatients AT annamachalinska impactofvascularriskfactorsonthethicknessandvolumeofthechoroidinamdpatients
_version_	1718379049700556800

The impact of vascular risk factors on the thickness and volume of the choroid in AMD patients

Ejemplares similares