Perioperative Doppler measurements of renal perfusion are associated with acute kidney injury in patients undergoing cardiac surgery

Abstract Acute kidney injury (AKI) is a frequent and severe complication in cardiac surgery. Normal renal function is dependent on adequate renal perfusion, which may be altered in the perioperative period. Renal perfusion can be assessed with Doppler measurement. We aimed to determine the associati...

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Autores principales:	Johan Lyngklip Hermansen, Gabriela Pettey, Heidi Tofte Sørensen, Samantha Nel, Nqoba Tsabedze, Arne Hørlyck, Palesa Motshabi Chakane, Henrik Gammelager, Peter Juhl-Olsen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6a6ad9fcfefd4c2eb04dce68b9239dda
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spelling	oai:doaj.org-article:6a6ad9fcfefd4c2eb04dce68b9239dda2021-12-02T17:13:17ZPerioperative Doppler measurements of renal perfusion are associated with acute kidney injury in patients undergoing cardiac surgery10.1038/s41598-021-99141-y2045-2322https://doaj.org/article/6a6ad9fcfefd4c2eb04dce68b9239dda2021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99141-yhttps://doaj.org/toc/2045-2322Abstract Acute kidney injury (AKI) is a frequent and severe complication in cardiac surgery. Normal renal function is dependent on adequate renal perfusion, which may be altered in the perioperative period. Renal perfusion can be assessed with Doppler measurement. We aimed to determine the association between Doppler measurements of renal perfusion and the development of AKI. This was a prospective, observational study of 100 patients with ≥ one risk factor for postoperative AKI undergoing open-heart surgery. Doppler ultrasound examinations were performed before surgery and on the first and fourth postoperative day. AKI was defined according to the KDIGO criteria and subdivided into mild (KDIGO stage 1) and severe AKI (KDIGO stage 2 + 3). Thirty-three patients developed AKI, 25 developed mild and eight developed severe AKI. Abnormal renal venous flow pattern on the first postoperative day was significantly associated with the development of severe AKI (OR 8.54 (95% CI 1.01; 72.2), P = 0.046), as were portal pulsatility fraction (OR 1.07 (95% CI 1.02; 1.13), P = 0.005). Point-of-care Doppler ultrasound measurements of renal perfusion are associated with the development of AKI after cardiac surgery. Renal and portal Doppler ultrasonography can be used to identify patients at high risk or very low risk of AKI after cardiac surgery.Johan Lyngklip HermansenGabriela PetteyHeidi Tofte SørensenSamantha NelNqoba TsabedzeArne HørlyckPalesa Motshabi ChakaneHenrik GammelagerPeter Juhl-OlsenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Johan Lyngklip Hermansen Gabriela Pettey Heidi Tofte Sørensen Samantha Nel Nqoba Tsabedze Arne Hørlyck Palesa Motshabi Chakane Henrik Gammelager Peter Juhl-Olsen Perioperative Doppler measurements of renal perfusion are associated with acute kidney injury in patients undergoing cardiac surgery
description	Abstract Acute kidney injury (AKI) is a frequent and severe complication in cardiac surgery. Normal renal function is dependent on adequate renal perfusion, which may be altered in the perioperative period. Renal perfusion can be assessed with Doppler measurement. We aimed to determine the association between Doppler measurements of renal perfusion and the development of AKI. This was a prospective, observational study of 100 patients with ≥ one risk factor for postoperative AKI undergoing open-heart surgery. Doppler ultrasound examinations were performed before surgery and on the first and fourth postoperative day. AKI was defined according to the KDIGO criteria and subdivided into mild (KDIGO stage 1) and severe AKI (KDIGO stage 2 + 3). Thirty-three patients developed AKI, 25 developed mild and eight developed severe AKI. Abnormal renal venous flow pattern on the first postoperative day was significantly associated with the development of severe AKI (OR 8.54 (95% CI 1.01; 72.2), P = 0.046), as were portal pulsatility fraction (OR 1.07 (95% CI 1.02; 1.13), P = 0.005). Point-of-care Doppler ultrasound measurements of renal perfusion are associated with the development of AKI after cardiac surgery. Renal and portal Doppler ultrasonography can be used to identify patients at high risk or very low risk of AKI after cardiac surgery.
format	article
author	Johan Lyngklip Hermansen Gabriela Pettey Heidi Tofte Sørensen Samantha Nel Nqoba Tsabedze Arne Hørlyck Palesa Motshabi Chakane Henrik Gammelager Peter Juhl-Olsen
author_facet	Johan Lyngklip Hermansen Gabriela Pettey Heidi Tofte Sørensen Samantha Nel Nqoba Tsabedze Arne Hørlyck Palesa Motshabi Chakane Henrik Gammelager Peter Juhl-Olsen
author_sort	Johan Lyngklip Hermansen
title	Perioperative Doppler measurements of renal perfusion are associated with acute kidney injury in patients undergoing cardiac surgery
title_short	Perioperative Doppler measurements of renal perfusion are associated with acute kidney injury in patients undergoing cardiac surgery
title_full	Perioperative Doppler measurements of renal perfusion are associated with acute kidney injury in patients undergoing cardiac surgery
title_fullStr	Perioperative Doppler measurements of renal perfusion are associated with acute kidney injury in patients undergoing cardiac surgery
title_full_unstemmed	Perioperative Doppler measurements of renal perfusion are associated with acute kidney injury in patients undergoing cardiac surgery
title_sort	perioperative doppler measurements of renal perfusion are associated with acute kidney injury in patients undergoing cardiac surgery
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6a6ad9fcfefd4c2eb04dce68b9239dda
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Perioperative Doppler measurements of renal perfusion are associated with acute kidney injury in patients undergoing cardiac surgery

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