Structural properties of the Caenorhabditis elegans neuronal network.

Despite recent interest in reconstructing neuronal networks, complete wiring diagrams on the level of individual synapses remain scarce and the insights into function they can provide remain unclear. Even for Caenorhabditis elegans, whose neuronal network is relatively small and stereotypical from a...

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Autores principales:	Lav R Varshney, Beth L Chen, Eric Paniagua, David H Hall, Dmitri B Chklovskii
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/6a6b03e9bb5444bc8c8b95ad9759c879
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spelling	oai:doaj.org-article:6a6b03e9bb5444bc8c8b95ad9759c8792021-11-18T05:50:45ZStructural properties of the Caenorhabditis elegans neuronal network.1553-734X1553-735810.1371/journal.pcbi.1001066https://doaj.org/article/6a6b03e9bb5444bc8c8b95ad9759c8792011-02-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21304930/pdf/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Despite recent interest in reconstructing neuronal networks, complete wiring diagrams on the level of individual synapses remain scarce and the insights into function they can provide remain unclear. Even for Caenorhabditis elegans, whose neuronal network is relatively small and stereotypical from animal to animal, published wiring diagrams are neither accurate nor complete and self-consistent. Using materials from White et al. and new electron micrographs we assemble whole, self-consistent gap junction and chemical synapse networks of hermaphrodite C. elegans. We propose a method to visualize the wiring diagram, which reflects network signal flow. We calculate statistical and topological properties of the network, such as degree distributions, synaptic multiplicities, and small-world properties, that help in understanding network signal propagation. We identify neurons that may play central roles in information processing, and network motifs that could serve as functional modules of the network. We explore propagation of neuronal activity in response to sensory or artificial stimulation using linear systems theory and find several activity patterns that could serve as substrates of previously described behaviors. Finally, we analyze the interaction between the gap junction and the chemical synapse networks. Since several statistical properties of the C. elegans network, such as multiplicity and motif distributions are similar to those found in mammalian neocortex, they likely point to general principles of neuronal networks. The wiring diagram reported here can help in understanding the mechanistic basis of behavior by generating predictions about future experiments involving genetic perturbations, laser ablations, or monitoring propagation of neuronal activity in response to stimulation.Lav R VarshneyBeth L ChenEric PaniaguaDavid H HallDmitri B ChklovskiiPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 7, Iss 2, p e1001066 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Lav R Varshney Beth L Chen Eric Paniagua David H Hall Dmitri B Chklovskii Structural properties of the Caenorhabditis elegans neuronal network.
description	Despite recent interest in reconstructing neuronal networks, complete wiring diagrams on the level of individual synapses remain scarce and the insights into function they can provide remain unclear. Even for Caenorhabditis elegans, whose neuronal network is relatively small and stereotypical from animal to animal, published wiring diagrams are neither accurate nor complete and self-consistent. Using materials from White et al. and new electron micrographs we assemble whole, self-consistent gap junction and chemical synapse networks of hermaphrodite C. elegans. We propose a method to visualize the wiring diagram, which reflects network signal flow. We calculate statistical and topological properties of the network, such as degree distributions, synaptic multiplicities, and small-world properties, that help in understanding network signal propagation. We identify neurons that may play central roles in information processing, and network motifs that could serve as functional modules of the network. We explore propagation of neuronal activity in response to sensory or artificial stimulation using linear systems theory and find several activity patterns that could serve as substrates of previously described behaviors. Finally, we analyze the interaction between the gap junction and the chemical synapse networks. Since several statistical properties of the C. elegans network, such as multiplicity and motif distributions are similar to those found in mammalian neocortex, they likely point to general principles of neuronal networks. The wiring diagram reported here can help in understanding the mechanistic basis of behavior by generating predictions about future experiments involving genetic perturbations, laser ablations, or monitoring propagation of neuronal activity in response to stimulation.
format	article
author	Lav R Varshney Beth L Chen Eric Paniagua David H Hall Dmitri B Chklovskii
author_facet	Lav R Varshney Beth L Chen Eric Paniagua David H Hall Dmitri B Chklovskii
author_sort	Lav R Varshney
title	Structural properties of the Caenorhabditis elegans neuronal network.
title_short	Structural properties of the Caenorhabditis elegans neuronal network.
title_full	Structural properties of the Caenorhabditis elegans neuronal network.
title_fullStr	Structural properties of the Caenorhabditis elegans neuronal network.
title_full_unstemmed	Structural properties of the Caenorhabditis elegans neuronal network.
title_sort	structural properties of the caenorhabditis elegans neuronal network.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/6a6b03e9bb5444bc8c8b95ad9759c879
work_keys_str_mv	AT lavrvarshney structuralpropertiesofthecaenorhabditiselegansneuronalnetwork AT bethlchen structuralpropertiesofthecaenorhabditiselegansneuronalnetwork AT ericpaniagua structuralpropertiesofthecaenorhabditiselegansneuronalnetwork AT davidhhall structuralpropertiesofthecaenorhabditiselegansneuronalnetwork AT dmitribchklovskii structuralpropertiesofthecaenorhabditiselegansneuronalnetwork
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Structural properties of the Caenorhabditis elegans neuronal network.

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