Broadband criticality of human brain network synchronization.

Self-organized criticality is an attractive model for human brain dynamics, but there has been little direct evidence for its existence in large-scale systems measured by neuroimaging. In general, critical systems are associated with fractal or power law scaling, long-range correlations in space and...

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Autores principales:	Manfred G Kitzbichler, Marie L Smith, Søren R Christensen, Ed Bullmore
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/6a6b72a026ea4e629f1ec5cbbf5520fa
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spelling	oai:doaj.org-article:6a6b72a026ea4e629f1ec5cbbf5520fa2021-11-25T05:41:47ZBroadband criticality of human brain network synchronization.1553-734X1553-735810.1371/journal.pcbi.1000314https://doaj.org/article/6a6b72a026ea4e629f1ec5cbbf5520fa2009-03-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19300473/pdf/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Self-organized criticality is an attractive model for human brain dynamics, but there has been little direct evidence for its existence in large-scale systems measured by neuroimaging. In general, critical systems are associated with fractal or power law scaling, long-range correlations in space and time, and rapid reconfiguration in response to external inputs. Here, we consider two measures of phase synchronization: the phase-lock interval, or duration of coupling between a pair of (neurophysiological) processes, and the lability of global synchronization of a (brain functional) network. Using computational simulations of two mechanistically distinct systems displaying complex dynamics, the Ising model and the Kuramoto model, we show that both synchronization metrics have power law probability distributions specifically when these systems are in a critical state. We then demonstrate power law scaling of both pairwise and global synchronization metrics in functional MRI and magnetoencephalographic data recorded from normal volunteers under resting conditions. These results strongly suggest that human brain functional systems exist in an endogenous state of dynamical criticality, characterized by a greater than random probability of both prolonged periods of phase-locking and occurrence of large rapid changes in the state of global synchronization, analogous to the neuronal "avalanches" previously described in cellular systems. Moreover, evidence for critical dynamics was identified consistently in neurophysiological systems operating at frequency intervals ranging from 0.05-0.11 to 62.5-125 Hz, confirming that criticality is a property of human brain functional network organization at all frequency intervals in the brain's physiological bandwidth.Manfred G KitzbichlerMarie L SmithSøren R ChristensenEd BullmorePublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 5, Iss 3, p e1000314 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Manfred G Kitzbichler Marie L Smith Søren R Christensen Ed Bullmore Broadband criticality of human brain network synchronization.
description	Self-organized criticality is an attractive model for human brain dynamics, but there has been little direct evidence for its existence in large-scale systems measured by neuroimaging. In general, critical systems are associated with fractal or power law scaling, long-range correlations in space and time, and rapid reconfiguration in response to external inputs. Here, we consider two measures of phase synchronization: the phase-lock interval, or duration of coupling between a pair of (neurophysiological) processes, and the lability of global synchronization of a (brain functional) network. Using computational simulations of two mechanistically distinct systems displaying complex dynamics, the Ising model and the Kuramoto model, we show that both synchronization metrics have power law probability distributions specifically when these systems are in a critical state. We then demonstrate power law scaling of both pairwise and global synchronization metrics in functional MRI and magnetoencephalographic data recorded from normal volunteers under resting conditions. These results strongly suggest that human brain functional systems exist in an endogenous state of dynamical criticality, characterized by a greater than random probability of both prolonged periods of phase-locking and occurrence of large rapid changes in the state of global synchronization, analogous to the neuronal "avalanches" previously described in cellular systems. Moreover, evidence for critical dynamics was identified consistently in neurophysiological systems operating at frequency intervals ranging from 0.05-0.11 to 62.5-125 Hz, confirming that criticality is a property of human brain functional network organization at all frequency intervals in the brain's physiological bandwidth.
format	article
author	Manfred G Kitzbichler Marie L Smith Søren R Christensen Ed Bullmore
author_facet	Manfred G Kitzbichler Marie L Smith Søren R Christensen Ed Bullmore
author_sort	Manfred G Kitzbichler
title	Broadband criticality of human brain network synchronization.
title_short	Broadband criticality of human brain network synchronization.
title_full	Broadband criticality of human brain network synchronization.
title_fullStr	Broadband criticality of human brain network synchronization.
title_full_unstemmed	Broadband criticality of human brain network synchronization.
title_sort	broadband criticality of human brain network synchronization.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/6a6b72a026ea4e629f1ec5cbbf5520fa
work_keys_str_mv	AT manfredgkitzbichler broadbandcriticalityofhumanbrainnetworksynchronization AT marielsmith broadbandcriticalityofhumanbrainnetworksynchronization AT sørenrchristensen broadbandcriticalityofhumanbrainnetworksynchronization AT edbullmore broadbandcriticalityofhumanbrainnetworksynchronization
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Broadband criticality of human brain network synchronization.

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