The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure

The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure

The MiDAC complex recruits class I histone deacetylases to chromatin but little is known about its precise structure and function. Here, the authors explore the role of MiDAC in the cell cycle and during mouse embryogenesis, and present cryoEM structures that provide insight into MiDAC’s mode of ass...

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Autores principales: Robert E. Turnbull, Louise Fairall, Almutasem Saleh, Emma Kelsall, Kyle L. Morris, T. J. Ragan, Christos G. Savva, Aditya Chandru, Christopher J. Millard, Olga V. Makarova, Corinne J. Smith, Alan M. Roseman, Andrew M. Fry, Shaun M. Cowley, John W. R. Schwabe
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/6a71d260306a424c936ce21edc133482
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spelling oai:doaj.org-article:6a71d260306a424c936ce21edc1334822021-12-02T17:12:20ZThe MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure10.1038/s41467-020-17078-82041-1723https://doaj.org/article/6a71d260306a424c936ce21edc1334822020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17078-8https://doaj.org/toc/2041-1723The MiDAC complex recruits class I histone deacetylases to chromatin but little is known about its precise structure and function. Here, the authors explore the role of MiDAC in the cell cycle and during mouse embryogenesis, and present cryoEM structures that provide insight into MiDAC’s mode of assembly.Robert E. TurnbullLouise FairallAlmutasem SalehEmma KelsallKyle L. MorrisT. J. RaganChristos G. SavvaAditya ChandruChristopher J. MillardOlga V. MakarovaCorinne J. SmithAlan M. RosemanAndrew M. FryShaun M. CowleyJohn W. R. SchwabeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Robert E. Turnbull
Louise Fairall
Almutasem Saleh
Emma Kelsall
Kyle L. Morris
T. J. Ragan
Christos G. Savva
Aditya Chandru
Christopher J. Millard
Olga V. Makarova
Corinne J. Smith
Alan M. Roseman
Andrew M. Fry
Shaun M. Cowley
John W. R. Schwabe
The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure
description The MiDAC complex recruits class I histone deacetylases to chromatin but little is known about its precise structure and function. Here, the authors explore the role of MiDAC in the cell cycle and during mouse embryogenesis, and present cryoEM structures that provide insight into MiDAC’s mode of assembly.
format article
author Robert E. Turnbull
Louise Fairall
Almutasem Saleh
Emma Kelsall
Kyle L. Morris
T. J. Ragan
Christos G. Savva
Aditya Chandru
Christopher J. Millard
Olga V. Makarova
Corinne J. Smith
Alan M. Roseman
Andrew M. Fry
Shaun M. Cowley
John W. R. Schwabe
author_facet Robert E. Turnbull
Louise Fairall
Almutasem Saleh
Emma Kelsall
Kyle L. Morris
T. J. Ragan
Christos G. Savva
Aditya Chandru
Christopher J. Millard
Olga V. Makarova
Corinne J. Smith
Alan M. Roseman
Andrew M. Fry
Shaun M. Cowley
John W. R. Schwabe
author_sort Robert E. Turnbull
title The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure
title_short The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure
title_full The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure
title_fullStr The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure
title_full_unstemmed The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure
title_sort midac histone deacetylase complex is essential for embryonic development and has a unique multivalent structure
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/6a71d260306a424c936ce21edc133482
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