Beige adipocytes mediate the neuroprotective and anti-inflammatory effects of subcutaneous fat in obese mice

Visceral adiposity is a risk factor for cognitive decline, but subcutaneous adipose tissue (SAT) is not and may be protective. Here, the authors show that beige adipocytes are indispensable for the neuroprotective effects of SAT. Beige fat knockout mice were more susceptible to the neuroimmune and c...

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Autores principales:	De-Huang Guo, Masaki Yamamoto, Caterina M. Hernandez, Hesam Khodadadi, Babak Baban, Alexis M. Stranahan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6a721c53c0ba40748c1d57563d2efd85
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spelling	oai:doaj.org-article:6a721c53c0ba40748c1d57563d2efd852021-12-02T16:30:11ZBeige adipocytes mediate the neuroprotective and anti-inflammatory effects of subcutaneous fat in obese mice10.1038/s41467-021-24540-82041-1723https://doaj.org/article/6a721c53c0ba40748c1d57563d2efd852021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24540-8https://doaj.org/toc/2041-1723Visceral adiposity is a risk factor for cognitive decline, but subcutaneous adipose tissue (SAT) is not and may be protective. Here, the authors show that beige adipocytes are indispensable for the neuroprotective effects of SAT. Beige fat knockout mice were more susceptible to the neuroimmune and cognitive effects of obesity, and in normal mice, SAT transplants protected against chronic obesity via beige fat-dependent mechanisms.De-Huang GuoMasaki YamamotoCaterina M. HernandezHesam KhodadadiBabak BabanAlexis M. StranahanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q De-Huang Guo Masaki Yamamoto Caterina M. Hernandez Hesam Khodadadi Babak Baban Alexis M. Stranahan Beige adipocytes mediate the neuroprotective and anti-inflammatory effects of subcutaneous fat in obese mice
description	Visceral adiposity is a risk factor for cognitive decline, but subcutaneous adipose tissue (SAT) is not and may be protective. Here, the authors show that beige adipocytes are indispensable for the neuroprotective effects of SAT. Beige fat knockout mice were more susceptible to the neuroimmune and cognitive effects of obesity, and in normal mice, SAT transplants protected against chronic obesity via beige fat-dependent mechanisms.
format	article
author	De-Huang Guo Masaki Yamamoto Caterina M. Hernandez Hesam Khodadadi Babak Baban Alexis M. Stranahan
author_facet	De-Huang Guo Masaki Yamamoto Caterina M. Hernandez Hesam Khodadadi Babak Baban Alexis M. Stranahan
author_sort	De-Huang Guo
title	Beige adipocytes mediate the neuroprotective and anti-inflammatory effects of subcutaneous fat in obese mice
title_short	Beige adipocytes mediate the neuroprotective and anti-inflammatory effects of subcutaneous fat in obese mice
title_full	Beige adipocytes mediate the neuroprotective and anti-inflammatory effects of subcutaneous fat in obese mice
title_fullStr	Beige adipocytes mediate the neuroprotective and anti-inflammatory effects of subcutaneous fat in obese mice
title_full_unstemmed	Beige adipocytes mediate the neuroprotective and anti-inflammatory effects of subcutaneous fat in obese mice
title_sort	beige adipocytes mediate the neuroprotective and anti-inflammatory effects of subcutaneous fat in obese mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6a721c53c0ba40748c1d57563d2efd85
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Beige adipocytes mediate the neuroprotective and anti-inflammatory effects of subcutaneous fat in obese mice

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