Immune-Mediated Necrotizing Myopathy Initially Presenting as Erythema Nodosum

Shuni Ying, Sheng Li, Shunli Tang, Qingmiao Sun, Deren Fang, Yali Li, Dingxian Zhu, Hong Fang, Jianjun Qiao Department of Dermatology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, People’s Republic of ChinaCorrespondence: Jianjun Qiao; Hong FangDe...

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Autores principales:	Ying S, Li S, Tang S, Sun Q, Fang D, Li Y, Zhu D, Fang H, Qiao J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	immune-mediated necrotizing myopathy erythema nodosum autoantibody Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/6a73ce6f00f14ed1bb6cbe6f0c33b842
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spelling	oai:doaj.org-article:6a73ce6f00f14ed1bb6cbe6f0c33b8422021-12-02T10:52:50ZImmune-Mediated Necrotizing Myopathy Initially Presenting as Erythema Nodosum1178-7031https://doaj.org/article/6a73ce6f00f14ed1bb6cbe6f0c33b8422020-08-01T00:00:00Zhttps://www.dovepress.com/immune-mediated-necrotizing-myopathy-initially-presenting-as-erythema--peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Shuni Ying, Sheng Li, Shunli Tang, Qingmiao Sun, Deren Fang, Yali Li, Dingxian Zhu, Hong Fang, Jianjun Qiao Department of Dermatology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, People’s Republic of ChinaCorrespondence: Jianjun Qiao; Hong FangDepartment of Dermatology, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79, Qingchun Road, Hangzhou 310003, People’s Republic of ChinaTel +86-571-87236385Email qiaojianjun@zju.edu.cn; fanghongzy@zju.edu.cnAbstract: Immune-mediated necrotizing myopathy (IMNM) is a type of autoimmune myopathy characterized by severe diffuse proximal myofiber necrosis in the context of inflammatory myopathy. Autoantibodies of anti-signal recognition particle and anti-hydroxy-3-methylglutaryl-CoA reductase are two antibodies specific to IMNM. Erythema nodosum (EN) is often accompanied by various systemic diseases, such as autoimmune diseases. Herein, we report a female patient with signal recognition particle-associated IMNM, with EN as the first presentation. She showed significant clinical improvement after the initiation of glucocorticoids, intravenous immunoglobulin, rituximab, and mycophenolate mofetil. This case indicates that IMNM can initially present as EN. IMNM and EN might have overlapping pathogeneses.Keywords: immune-mediated necrotizing myopathy, erythema nodosum, autoantibodyYing SLi STang SSun QFang DLi YZhu DFang HQiao JDove Medical Pressarticleimmune-mediated necrotizing myopathyerythema nodosumautoantibodyPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 13, Pp 471-476 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	immune-mediated necrotizing myopathy erythema nodosum autoantibody Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	immune-mediated necrotizing myopathy erythema nodosum autoantibody Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Ying S Li S Tang S Sun Q Fang D Li Y Zhu D Fang H Qiao J Immune-Mediated Necrotizing Myopathy Initially Presenting as Erythema Nodosum
description	Shuni Ying, Sheng Li, Shunli Tang, Qingmiao Sun, Deren Fang, Yali Li, Dingxian Zhu, Hong Fang, Jianjun Qiao Department of Dermatology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, People’s Republic of ChinaCorrespondence: Jianjun Qiao; Hong FangDepartment of Dermatology, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79, Qingchun Road, Hangzhou 310003, People’s Republic of ChinaTel +86-571-87236385Email qiaojianjun@zju.edu.cn; fanghongzy@zju.edu.cnAbstract: Immune-mediated necrotizing myopathy (IMNM) is a type of autoimmune myopathy characterized by severe diffuse proximal myofiber necrosis in the context of inflammatory myopathy. Autoantibodies of anti-signal recognition particle and anti-hydroxy-3-methylglutaryl-CoA reductase are two antibodies specific to IMNM. Erythema nodosum (EN) is often accompanied by various systemic diseases, such as autoimmune diseases. Herein, we report a female patient with signal recognition particle-associated IMNM, with EN as the first presentation. She showed significant clinical improvement after the initiation of glucocorticoids, intravenous immunoglobulin, rituximab, and mycophenolate mofetil. This case indicates that IMNM can initially present as EN. IMNM and EN might have overlapping pathogeneses.Keywords: immune-mediated necrotizing myopathy, erythema nodosum, autoantibody
format	article
author	Ying S Li S Tang S Sun Q Fang D Li Y Zhu D Fang H Qiao J
author_facet	Ying S Li S Tang S Sun Q Fang D Li Y Zhu D Fang H Qiao J
author_sort	Ying S
title	Immune-Mediated Necrotizing Myopathy Initially Presenting as Erythema Nodosum
title_short	Immune-Mediated Necrotizing Myopathy Initially Presenting as Erythema Nodosum
title_full	Immune-Mediated Necrotizing Myopathy Initially Presenting as Erythema Nodosum
title_fullStr	Immune-Mediated Necrotizing Myopathy Initially Presenting as Erythema Nodosum
title_full_unstemmed	Immune-Mediated Necrotizing Myopathy Initially Presenting as Erythema Nodosum
title_sort	immune-mediated necrotizing myopathy initially presenting as erythema nodosum
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/6a73ce6f00f14ed1bb6cbe6f0c33b842
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Immune-Mediated Necrotizing Myopathy Initially Presenting as Erythema Nodosum

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