Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions

Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions

Cancer cells adapt their metabolism to survive limited nutrient availability. Here, the authors show that in conditions of limited glucose or glutamine availability, pancreatic ductal adenocarcinoma cells can use collagen-derived proline to foster the TCA cycle and allow cell survival bothin vitro a...

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Autores principales: Orianne Olivares, Jared R. Mayers, Victoire Gouirand, Margaret E. Torrence, Tristan Gicquel, Laurence Borge, Sophie Lac, Julie Roques, Marie-Noëlle Lavaut, Patrice Berthezène, Marion Rubis, Veronique Secq, Stéphane Garcia, Vincent Moutardier, Dominique Lombardo, Juan Lucio Iovanna, Richard Tomasini, Fabienne Guillaumond, Matthew G. Vander Heiden, Sophie Vasseur
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/6a73d2e74efe45e79489251d11428d7b
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spelling oai:doaj.org-article:6a73d2e74efe45e79489251d11428d7b2021-12-02T14:42:44ZCollagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions10.1038/ncomms160312041-1723https://doaj.org/article/6a73d2e74efe45e79489251d11428d7b2017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms16031https://doaj.org/toc/2041-1723Cancer cells adapt their metabolism to survive limited nutrient availability. Here, the authors show that in conditions of limited glucose or glutamine availability, pancreatic ductal adenocarcinoma cells can use collagen-derived proline to foster the TCA cycle and allow cell survival bothin vitro and in vivo.Orianne OlivaresJared R. MayersVictoire GouirandMargaret E. TorrenceTristan GicquelLaurence BorgeSophie LacJulie RoquesMarie-Noëlle LavautPatrice BerthezèneMarion RubisVeronique SecqStéphane GarciaVincent MoutardierDominique LombardoJuan Lucio IovannaRichard TomasiniFabienne GuillaumondMatthew G. Vander HeidenSophie VasseurNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Orianne Olivares
Jared R. Mayers
Victoire Gouirand
Margaret E. Torrence
Tristan Gicquel
Laurence Borge
Sophie Lac
Julie Roques
Marie-Noëlle Lavaut
Patrice Berthezène
Marion Rubis
Veronique Secq
Stéphane Garcia
Vincent Moutardier
Dominique Lombardo
Juan Lucio Iovanna
Richard Tomasini
Fabienne Guillaumond
Matthew G. Vander Heiden
Sophie Vasseur
Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions
description Cancer cells adapt their metabolism to survive limited nutrient availability. Here, the authors show that in conditions of limited glucose or glutamine availability, pancreatic ductal adenocarcinoma cells can use collagen-derived proline to foster the TCA cycle and allow cell survival bothin vitro and in vivo.
format article
author Orianne Olivares
Jared R. Mayers
Victoire Gouirand
Margaret E. Torrence
Tristan Gicquel
Laurence Borge
Sophie Lac
Julie Roques
Marie-Noëlle Lavaut
Patrice Berthezène
Marion Rubis
Veronique Secq
Stéphane Garcia
Vincent Moutardier
Dominique Lombardo
Juan Lucio Iovanna
Richard Tomasini
Fabienne Guillaumond
Matthew G. Vander Heiden
Sophie Vasseur
author_facet Orianne Olivares
Jared R. Mayers
Victoire Gouirand
Margaret E. Torrence
Tristan Gicquel
Laurence Borge
Sophie Lac
Julie Roques
Marie-Noëlle Lavaut
Patrice Berthezène
Marion Rubis
Veronique Secq
Stéphane Garcia
Vincent Moutardier
Dominique Lombardo
Juan Lucio Iovanna
Richard Tomasini
Fabienne Guillaumond
Matthew G. Vander Heiden
Sophie Vasseur
author_sort Orianne Olivares
title Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions
title_short Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions
title_full Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions
title_fullStr Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions
title_full_unstemmed Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions
title_sort collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/6a73d2e74efe45e79489251d11428d7b
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