Case-area targeted interventions (CATI) for reactive dengue control: Modelling effectiveness of vector control and prophylactic drugs in Singapore.

<h4>Background</h4>Targeting interventions to areas that have recently experienced cases of disease is one strategy to contain outbreaks of infectious disease. Such case-area targeted interventions (CATI) have become an increasingly popular approach for dengue control but there is little...

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Autores principales:	Oliver J Brady, Adam J Kucharski, Sebastian Funk, Yalda Jafari, Marnix Van Loock, Guillermo Herrera-Taracena, Joris Menten, W John Edmunds, Shuzhen Sim, Lee-Ching Ng, Stéphane Hué, Martin L Hibberd
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/6a745354fac048e69f32bee0153e1f90
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spelling	oai:doaj.org-article:6a745354fac048e69f32bee0153e1f902021-12-02T20:23:40ZCase-area targeted interventions (CATI) for reactive dengue control: Modelling effectiveness of vector control and prophylactic drugs in Singapore.1935-27271935-273510.1371/journal.pntd.0009562https://doaj.org/article/6a745354fac048e69f32bee0153e1f902021-08-01T00:00:00Zhttps://doi.org/10.1371/journal.pntd.0009562https://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735<h4>Background</h4>Targeting interventions to areas that have recently experienced cases of disease is one strategy to contain outbreaks of infectious disease. Such case-area targeted interventions (CATI) have become an increasingly popular approach for dengue control but there is little evidence to suggest how precisely targeted or how recent cases need to be, to mount an effective response. The growing interest in the development of prophylactic and therapeutic drugs for dengue has also given new relevance for CATI strategies to interrupt transmission or deliver early treatment.<h4>Methods/principal findings</h4>Here we develop a patch-based mathematical model of spatial dengue spread and fit it to spatiotemporal datasets from Singapore. Simulations from this model suggest CATI strategies could be effective, particularly if used in lower density areas. To maximise effectiveness, increasing the size of the radius around an index case should be prioritised even if it results in delays in the intervention being applied. This is partially because large intervention radii ensure individuals receive multiple and regular rounds of drug dosing or vector control, and thus boost overall coverage. Given equivalent efficacy, CATIs using prophylactic drugs are predicted to be more effective than adult mosquito-killing vector control methods and may even offer the possibility of interrupting individual chains of transmission if rapidly deployed. CATI strategies quickly lose their effectiveness if baseline transmission increases or case detection rates fall.<h4>Conclusions/significance</h4>These results suggest CATI strategies can play an important role in dengue control but are likely to be most relevant for low transmission areas where high coverage of other non-reactive interventions already exists. Controlled field trials are needed to assess the field efficacy and practical constraints of large operational CATI strategies.Oliver J BradyAdam J KucharskiSebastian FunkYalda JafariMarnix Van LoockGuillermo Herrera-TaracenaJoris MentenW John EdmundsShuzhen SimLee-Ching NgStéphane HuéMartin L HibberdPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 15, Iss 8, p e0009562 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Oliver J Brady Adam J Kucharski Sebastian Funk Yalda Jafari Marnix Van Loock Guillermo Herrera-Taracena Joris Menten W John Edmunds Shuzhen Sim Lee-Ching Ng Stéphane Hué Martin L Hibberd Case-area targeted interventions (CATI) for reactive dengue control: Modelling effectiveness of vector control and prophylactic drugs in Singapore.
description	<h4>Background</h4>Targeting interventions to areas that have recently experienced cases of disease is one strategy to contain outbreaks of infectious disease. Such case-area targeted interventions (CATI) have become an increasingly popular approach for dengue control but there is little evidence to suggest how precisely targeted or how recent cases need to be, to mount an effective response. The growing interest in the development of prophylactic and therapeutic drugs for dengue has also given new relevance for CATI strategies to interrupt transmission or deliver early treatment.<h4>Methods/principal findings</h4>Here we develop a patch-based mathematical model of spatial dengue spread and fit it to spatiotemporal datasets from Singapore. Simulations from this model suggest CATI strategies could be effective, particularly if used in lower density areas. To maximise effectiveness, increasing the size of the radius around an index case should be prioritised even if it results in delays in the intervention being applied. This is partially because large intervention radii ensure individuals receive multiple and regular rounds of drug dosing or vector control, and thus boost overall coverage. Given equivalent efficacy, CATIs using prophylactic drugs are predicted to be more effective than adult mosquito-killing vector control methods and may even offer the possibility of interrupting individual chains of transmission if rapidly deployed. CATI strategies quickly lose their effectiveness if baseline transmission increases or case detection rates fall.<h4>Conclusions/significance</h4>These results suggest CATI strategies can play an important role in dengue control but are likely to be most relevant for low transmission areas where high coverage of other non-reactive interventions already exists. Controlled field trials are needed to assess the field efficacy and practical constraints of large operational CATI strategies.
format	article
author	Oliver J Brady Adam J Kucharski Sebastian Funk Yalda Jafari Marnix Van Loock Guillermo Herrera-Taracena Joris Menten W John Edmunds Shuzhen Sim Lee-Ching Ng Stéphane Hué Martin L Hibberd
author_facet	Oliver J Brady Adam J Kucharski Sebastian Funk Yalda Jafari Marnix Van Loock Guillermo Herrera-Taracena Joris Menten W John Edmunds Shuzhen Sim Lee-Ching Ng Stéphane Hué Martin L Hibberd
author_sort	Oliver J Brady
title	Case-area targeted interventions (CATI) for reactive dengue control: Modelling effectiveness of vector control and prophylactic drugs in Singapore.
title_short	Case-area targeted interventions (CATI) for reactive dengue control: Modelling effectiveness of vector control and prophylactic drugs in Singapore.
title_full	Case-area targeted interventions (CATI) for reactive dengue control: Modelling effectiveness of vector control and prophylactic drugs in Singapore.
title_fullStr	Case-area targeted interventions (CATI) for reactive dengue control: Modelling effectiveness of vector control and prophylactic drugs in Singapore.
title_full_unstemmed	Case-area targeted interventions (CATI) for reactive dengue control: Modelling effectiveness of vector control and prophylactic drugs in Singapore.
title_sort	case-area targeted interventions (cati) for reactive dengue control: modelling effectiveness of vector control and prophylactic drugs in singapore.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/6a745354fac048e69f32bee0153e1f90
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Case-area targeted interventions (CATI) for reactive dengue control: Modelling effectiveness of vector control and prophylactic drugs in Singapore.

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