Genomic landscape associated with potential response to anti-CTLA-4 treatment in cancers

There is an urgent need to identify predictive markers for selecting responders to immunotherapy. Here, the authors describe a transcriptional predictor of immunotherapy response and assess it in genomic data from ~ 10,000 human tissues across 30 different cancer types.

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Autores principales:	Chan-Young Ock, Jun-Eul Hwang, Bhumsuk Keam, Sang-Bae Kim, Jae-Jun Shim, Hee-Jin Jang, Sarang Park, Bo Hwa Sohn, Minse Cha, Jaffer A. Ajani, Scott Kopetz, Keun-Wook Lee, Tae Min Kim, Dae Seog Heo, Ju-Seog Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6a7dbe118f55479d9642734712ad0d61
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spelling	oai:doaj.org-article:6a7dbe118f55479d9642734712ad0d612021-12-02T15:37:01ZGenomic landscape associated with potential response to anti-CTLA-4 treatment in cancers10.1038/s41467-017-01018-02041-1723https://doaj.org/article/6a7dbe118f55479d9642734712ad0d612017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01018-0https://doaj.org/toc/2041-1723There is an urgent need to identify predictive markers for selecting responders to immunotherapy. Here, the authors describe a transcriptional predictor of immunotherapy response and assess it in genomic data from ~ 10,000 human tissues across 30 different cancer types.Chan-Young OckJun-Eul HwangBhumsuk KeamSang-Bae KimJae-Jun ShimHee-Jin JangSarang ParkBo Hwa SohnMinse ChaJaffer A. AjaniScott KopetzKeun-Wook LeeTae Min KimDae Seog HeoJu-Seog LeeNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chan-Young Ock Jun-Eul Hwang Bhumsuk Keam Sang-Bae Kim Jae-Jun Shim Hee-Jin Jang Sarang Park Bo Hwa Sohn Minse Cha Jaffer A. Ajani Scott Kopetz Keun-Wook Lee Tae Min Kim Dae Seog Heo Ju-Seog Lee Genomic landscape associated with potential response to anti-CTLA-4 treatment in cancers
description	There is an urgent need to identify predictive markers for selecting responders to immunotherapy. Here, the authors describe a transcriptional predictor of immunotherapy response and assess it in genomic data from ~ 10,000 human tissues across 30 different cancer types.
format	article
author	Chan-Young Ock Jun-Eul Hwang Bhumsuk Keam Sang-Bae Kim Jae-Jun Shim Hee-Jin Jang Sarang Park Bo Hwa Sohn Minse Cha Jaffer A. Ajani Scott Kopetz Keun-Wook Lee Tae Min Kim Dae Seog Heo Ju-Seog Lee
author_facet	Chan-Young Ock Jun-Eul Hwang Bhumsuk Keam Sang-Bae Kim Jae-Jun Shim Hee-Jin Jang Sarang Park Bo Hwa Sohn Minse Cha Jaffer A. Ajani Scott Kopetz Keun-Wook Lee Tae Min Kim Dae Seog Heo Ju-Seog Lee
author_sort	Chan-Young Ock
title	Genomic landscape associated with potential response to anti-CTLA-4 treatment in cancers
title_short	Genomic landscape associated with potential response to anti-CTLA-4 treatment in cancers
title_full	Genomic landscape associated with potential response to anti-CTLA-4 treatment in cancers
title_fullStr	Genomic landscape associated with potential response to anti-CTLA-4 treatment in cancers
title_full_unstemmed	Genomic landscape associated with potential response to anti-CTLA-4 treatment in cancers
title_sort	genomic landscape associated with potential response to anti-ctla-4 treatment in cancers
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6a7dbe118f55479d9642734712ad0d61
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Genomic landscape associated with potential response to anti-CTLA-4 treatment in cancers

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