Comprehensive definition of human immunodominant CD8 antigens in tuberculosis

Tuberculosis: Defining the proteins that drive immune responses Specific bacterial proteins have been found that drive effective immune responses to tuberculosis, with use in making more effective vaccines. Immunity to tuberculosis (TB) is facilitated by two types of white blood cell; however, most...

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Autores principales:	Deborah A. Lewinsohn, Gwendolyn M. Swarbrick, Byung Park, Meghan E. Cansler, Megan D. Null, Katelynne G. Toren, Joy Baseke, Sarah Zalwango, Harriet Mayanja-Kizza, LaShaunda L. Malone, Melissa Nyendak, Guanming Wu, Kristi Guinn, Shannon McWeeney, Tomi Mori, Keith A. Chervenak, David R. Sherman, W. Henry Boom, David M. Lewinsohn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/6a7fcb5a9dd24cd682d8a9c35d006ba1
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spelling	oai:doaj.org-article:6a7fcb5a9dd24cd682d8a9c35d006ba12021-12-02T12:30:33ZComprehensive definition of human immunodominant CD8 antigens in tuberculosis10.1038/s41541-017-0008-62059-0105https://doaj.org/article/6a7fcb5a9dd24cd682d8a9c35d006ba12017-04-01T00:00:00Zhttps://doi.org/10.1038/s41541-017-0008-6https://doaj.org/toc/2059-0105Tuberculosis: Defining the proteins that drive immune responses Specific bacterial proteins have been found that drive effective immune responses to tuberculosis, with use in making more effective vaccines. Immunity to tuberculosis (TB) is facilitated by two types of white blood cell; however, most research has focused on one: the CD4+ T cell. Deborah A. Lewinsohn and David Lewinsohn, of the Oregon Health & Science University, USA, and collaborators lay out the essential functions of the oft-neglected CD8+ T cell, and undertook a broad approach to catalogue and define the bacterial proteins that activate the CD8+ T cell response. The team found that TB-infected humans reacted strongly to their protein library, and described several characteristics of CD8+ T cell ‘antigens’ (activators of immune cells) that will likely prove highly useful in the design of more protective TB vaccines.Deborah A. LewinsohnGwendolyn M. SwarbrickByung ParkMeghan E. CanslerMegan D. NullKatelynne G. TorenJoy BasekeSarah ZalwangoHarriet Mayanja-KizzaLaShaunda L. MaloneMelissa NyendakGuanming WuKristi GuinnShannon McWeeneyTomi MoriKeith A. ChervenakDavid R. ShermanW. Henry BoomDavid M. LewinsohnNature PortfolioarticleImmunologic diseases. AllergyRC581-607Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Vaccines, Vol 2, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Deborah A. Lewinsohn Gwendolyn M. Swarbrick Byung Park Meghan E. Cansler Megan D. Null Katelynne G. Toren Joy Baseke Sarah Zalwango Harriet Mayanja-Kizza LaShaunda L. Malone Melissa Nyendak Guanming Wu Kristi Guinn Shannon McWeeney Tomi Mori Keith A. Chervenak David R. Sherman W. Henry Boom David M. Lewinsohn Comprehensive definition of human immunodominant CD8 antigens in tuberculosis
description	Tuberculosis: Defining the proteins that drive immune responses Specific bacterial proteins have been found that drive effective immune responses to tuberculosis, with use in making more effective vaccines. Immunity to tuberculosis (TB) is facilitated by two types of white blood cell; however, most research has focused on one: the CD4+ T cell. Deborah A. Lewinsohn and David Lewinsohn, of the Oregon Health & Science University, USA, and collaborators lay out the essential functions of the oft-neglected CD8+ T cell, and undertook a broad approach to catalogue and define the bacterial proteins that activate the CD8+ T cell response. The team found that TB-infected humans reacted strongly to their protein library, and described several characteristics of CD8+ T cell ‘antigens’ (activators of immune cells) that will likely prove highly useful in the design of more protective TB vaccines.
format	article
author	Deborah A. Lewinsohn Gwendolyn M. Swarbrick Byung Park Meghan E. Cansler Megan D. Null Katelynne G. Toren Joy Baseke Sarah Zalwango Harriet Mayanja-Kizza LaShaunda L. Malone Melissa Nyendak Guanming Wu Kristi Guinn Shannon McWeeney Tomi Mori Keith A. Chervenak David R. Sherman W. Henry Boom David M. Lewinsohn
author_facet	Deborah A. Lewinsohn Gwendolyn M. Swarbrick Byung Park Meghan E. Cansler Megan D. Null Katelynne G. Toren Joy Baseke Sarah Zalwango Harriet Mayanja-Kizza LaShaunda L. Malone Melissa Nyendak Guanming Wu Kristi Guinn Shannon McWeeney Tomi Mori Keith A. Chervenak David R. Sherman W. Henry Boom David M. Lewinsohn
author_sort	Deborah A. Lewinsohn
title	Comprehensive definition of human immunodominant CD8 antigens in tuberculosis
title_short	Comprehensive definition of human immunodominant CD8 antigens in tuberculosis
title_full	Comprehensive definition of human immunodominant CD8 antigens in tuberculosis
title_fullStr	Comprehensive definition of human immunodominant CD8 antigens in tuberculosis
title_full_unstemmed	Comprehensive definition of human immunodominant CD8 antigens in tuberculosis
title_sort	comprehensive definition of human immunodominant cd8 antigens in tuberculosis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6a7fcb5a9dd24cd682d8a9c35d006ba1
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Comprehensive definition of human immunodominant CD8 antigens in tuberculosis

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