Macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells

Abdominal aortic aneurysms (AAA) are characterized by extensive extracellular matrix degradation. Here Hadi et al. identify a netrin-1/neogenin-based crosstalk between macrophages and vascular smooth muscle cells (VSMCs), leading to the secretion of the matrix metalloproteinase MMP-3 by VSMCs and su...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tarik Hadi, Ludovic Boytard, Michele Silvestro, Dornazsadat Alebrahim, Samson Jacob, Jordyn Feinstein, Krista Barone, Wes Spiro, Susan Hutchison, Russell Simon, Debra Rateri, Florence Pinet, David Fenyo, Mark Adelman, Kathryn J. Moore, Holger K. Eltzschig, Alan Daugherty, Bhama Ramkhelawon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6a80aa6aa5a6430686da689e4970e306
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6a80aa6aa5a6430686da689e4970e306
record_format	dspace
spelling	oai:doaj.org-article:6a80aa6aa5a6430686da689e4970e3062021-12-02T16:49:34ZMacrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells10.1038/s41467-018-07495-12041-1723https://doaj.org/article/6a80aa6aa5a6430686da689e4970e3062018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07495-1https://doaj.org/toc/2041-1723Abdominal aortic aneurysms (AAA) are characterized by extensive extracellular matrix degradation. Here Hadi et al. identify a netrin-1/neogenin-based crosstalk between macrophages and vascular smooth muscle cells (VSMCs), leading to the secretion of the matrix metalloproteinase MMP-3 by VSMCs and subsequent matrix degradation in AAA lesions.Tarik HadiLudovic BoytardMichele SilvestroDornazsadat AlebrahimSamson JacobJordyn FeinsteinKrista BaroneWes SpiroSusan HutchisonRussell SimonDebra RateriFlorence PinetDavid FenyoMark AdelmanKathryn J. MooreHolger K. EltzschigAlan DaughertyBhama RamkhelawonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tarik Hadi Ludovic Boytard Michele Silvestro Dornazsadat Alebrahim Samson Jacob Jordyn Feinstein Krista Barone Wes Spiro Susan Hutchison Russell Simon Debra Rateri Florence Pinet David Fenyo Mark Adelman Kathryn J. Moore Holger K. Eltzschig Alan Daugherty Bhama Ramkhelawon Macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells
description	Abdominal aortic aneurysms (AAA) are characterized by extensive extracellular matrix degradation. Here Hadi et al. identify a netrin-1/neogenin-based crosstalk between macrophages and vascular smooth muscle cells (VSMCs), leading to the secretion of the matrix metalloproteinase MMP-3 by VSMCs and subsequent matrix degradation in AAA lesions.
format	article
author	Tarik Hadi Ludovic Boytard Michele Silvestro Dornazsadat Alebrahim Samson Jacob Jordyn Feinstein Krista Barone Wes Spiro Susan Hutchison Russell Simon Debra Rateri Florence Pinet David Fenyo Mark Adelman Kathryn J. Moore Holger K. Eltzschig Alan Daugherty Bhama Ramkhelawon
author_facet	Tarik Hadi Ludovic Boytard Michele Silvestro Dornazsadat Alebrahim Samson Jacob Jordyn Feinstein Krista Barone Wes Spiro Susan Hutchison Russell Simon Debra Rateri Florence Pinet David Fenyo Mark Adelman Kathryn J. Moore Holger K. Eltzschig Alan Daugherty Bhama Ramkhelawon
author_sort	Tarik Hadi
title	Macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells
title_short	Macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells
title_full	Macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells
title_fullStr	Macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells
title_full_unstemmed	Macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells
title_sort	macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating mmp3 in vascular smooth muscle cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/6a80aa6aa5a6430686da689e4970e306
work_keys_str_mv	AT tarikhadi macrophagederivednetrin1promotesabdominalaorticaneurysmformationbyactivatingmmp3invascularsmoothmusclecells AT ludovicboytard macrophagederivednetrin1promotesabdominalaorticaneurysmformationbyactivatingmmp3invascularsmoothmusclecells AT michelesilvestro macrophagederivednetrin1promotesabdominalaorticaneurysmformationbyactivatingmmp3invascularsmoothmusclecells AT dornazsadatalebrahim macrophagederivednetrin1promotesabdominalaorticaneurysmformationbyactivatingmmp3invascularsmoothmusclecells AT samsonjacob macrophagederivednetrin1promotesabdominalaorticaneurysmformationbyactivatingmmp3invascularsmoothmusclecells AT jordynfeinstein macrophagederivednetrin1promotesabdominalaorticaneurysmformationbyactivatingmmp3invascularsmoothmusclecells AT kristabarone macrophagederivednetrin1promotesabdominalaorticaneurysmformationbyactivatingmmp3invascularsmoothmusclecells AT wesspiro macrophagederivednetrin1promotesabdominalaorticaneurysmformationbyactivatingmmp3invascularsmoothmusclecells AT susanhutchison macrophagederivednetrin1promotesabdominalaorticaneurysmformationbyactivatingmmp3invascularsmoothmusclecells AT russellsimon macrophagederivednetrin1promotesabdominalaorticaneurysmformationbyactivatingmmp3invascularsmoothmusclecells AT debrarateri macrophagederivednetrin1promotesabdominalaorticaneurysmformationbyactivatingmmp3invascularsmoothmusclecells AT florencepinet macrophagederivednetrin1promotesabdominalaorticaneurysmformationbyactivatingmmp3invascularsmoothmusclecells AT davidfenyo macrophagederivednetrin1promotesabdominalaorticaneurysmformationbyactivatingmmp3invascularsmoothmusclecells AT markadelman macrophagederivednetrin1promotesabdominalaorticaneurysmformationbyactivatingmmp3invascularsmoothmusclecells AT kathrynjmoore macrophagederivednetrin1promotesabdominalaorticaneurysmformationbyactivatingmmp3invascularsmoothmusclecells AT holgerkeltzschig macrophagederivednetrin1promotesabdominalaorticaneurysmformationbyactivatingmmp3invascularsmoothmusclecells AT alandaugherty macrophagederivednetrin1promotesabdominalaorticaneurysmformationbyactivatingmmp3invascularsmoothmusclecells AT bhamaramkhelawon macrophagederivednetrin1promotesabdominalaorticaneurysmformationbyactivatingmmp3invascularsmoothmusclecells
_version_	1718383282040602624

Macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells

Ejemplares similares