Temporal dynamics of base excision/single-strand break repair protein complex assembly/disassembly are modulated by the PARP/NAD+/SIRT6 axis

Temporal dynamics of base excision/single-strand break repair protein complex assembly/disassembly are modulated by the PARP/NAD+/SIRT6 axis

Summary: Assembly and disassembly of DNA repair protein complexes at DNA damage sites are essential for maintaining genomic integrity. Investigating factors coordinating assembly of the base excision repair (BER) proteins DNA polymerase β (Polβ) and XRCC1 to DNA lesion sites identifies a role for Po...

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Detalles Bibliográficos
Autores principales: Christopher A. Koczor, Kate M. Saville, Joel F. Andrews, Jennifer Clark, Qingming Fang, Jianfeng Li, Rasha Q. Al-Rahahleh, Md Ibrahim, Steven McClellan, Mikhail V. Makarov, Marie E. Migaud, Robert W. Sobol
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
Materias:
DNA polymerase β
XRCC1
poly(ADP-ribose)
PAR
NAD+
NRH
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/6a82efe53d94463fb399bda39a6d5f71
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