Predicting the receptive range of olfactory receptors.

Although the family of genes encoding for olfactory receptors was identified more than 15 years ago, the difficulty of functionally expressing these receptors in an heterologous system has, with only some exceptions, rendered the receptive range of given olfactory receptors largely unknown. Furtherm...

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Autores principales:	Rafi Haddad, Liran Carmel, Noam Sobel, David Harel
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/6a8d0d7223e144578cdea528b9594d70
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spelling	oai:doaj.org-article:6a8d0d7223e144578cdea528b9594d702021-11-25T05:41:27ZPredicting the receptive range of olfactory receptors.1553-734X1553-735810.1371/journal.pcbi.0040018https://doaj.org/article/6a8d0d7223e144578cdea528b9594d702008-02-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18248088/pdf/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Although the family of genes encoding for olfactory receptors was identified more than 15 years ago, the difficulty of functionally expressing these receptors in an heterologous system has, with only some exceptions, rendered the receptive range of given olfactory receptors largely unknown. Furthermore, even when successfully expressed, the task of probing such a receptor with thousands of odors/ligands remains daunting. Here we provide proof of concept for a solution to this problem. Using computational methods, we tune an electronic nose to the receptive range of an olfactory receptor. We then use this electronic nose to predict the receptors' response to other odorants. Our method can be used to identify the receptive range of olfactory receptors, and can also be applied to other questions involving receptor-ligand interactions in non-olfactory settings.Rafi HaddadLiran CarmelNoam SobelDavid HarelPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 4, Iss 2, p e18 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Rafi Haddad Liran Carmel Noam Sobel David Harel Predicting the receptive range of olfactory receptors.
description	Although the family of genes encoding for olfactory receptors was identified more than 15 years ago, the difficulty of functionally expressing these receptors in an heterologous system has, with only some exceptions, rendered the receptive range of given olfactory receptors largely unknown. Furthermore, even when successfully expressed, the task of probing such a receptor with thousands of odors/ligands remains daunting. Here we provide proof of concept for a solution to this problem. Using computational methods, we tune an electronic nose to the receptive range of an olfactory receptor. We then use this electronic nose to predict the receptors' response to other odorants. Our method can be used to identify the receptive range of olfactory receptors, and can also be applied to other questions involving receptor-ligand interactions in non-olfactory settings.
format	article
author	Rafi Haddad Liran Carmel Noam Sobel David Harel
author_facet	Rafi Haddad Liran Carmel Noam Sobel David Harel
author_sort	Rafi Haddad
title	Predicting the receptive range of olfactory receptors.
title_short	Predicting the receptive range of olfactory receptors.
title_full	Predicting the receptive range of olfactory receptors.
title_fullStr	Predicting the receptive range of olfactory receptors.
title_full_unstemmed	Predicting the receptive range of olfactory receptors.
title_sort	predicting the receptive range of olfactory receptors.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/6a8d0d7223e144578cdea528b9594d70
work_keys_str_mv	AT rafihaddad predictingthereceptiverangeofolfactoryreceptors AT lirancarmel predictingthereceptiverangeofolfactoryreceptors AT noamsobel predictingthereceptiverangeofolfactoryreceptors AT davidharel predictingthereceptiverangeofolfactoryreceptors
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Predicting the receptive range of olfactory receptors.

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