Circadian control of hepatitis B virus replication

The circadian factors BMAL1/CLOCK and REV-ERB are master regulators of the human liver transcriptome but their role in hepatitis B virus infection is largely unknown. Here, Zhuang et al. show that REV-ERB regulates hepatitis B virus entry and BMAL1 directly binds HBV DNA and activates viral genome t...

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Autores principales:	Xiaodong Zhuang, Donall Forde, Senko Tsukuda, Valentina D’Arienzo, Laurent Mailly, James M. Harris, Peter A. C. Wing, Helene Borrmann, Mirjam Schilling, Andrea Magri, Claudia Orbegozo Rubio, Robert J. Maidstone, Mudassar Iqbal, Miguel Garzon, Rosalba Minisini, Mario Pirisi, Sam Butterworth, Peter Balfe, David W. Ray, Koichi Watashi, Thomas F. Baumert, Jane A. McKeating
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6a8ef38d436d4d3fbb7a5a30aa9a40f8
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spelling	oai:doaj.org-article:6a8ef38d436d4d3fbb7a5a30aa9a40f82021-12-02T13:30:36ZCircadian control of hepatitis B virus replication10.1038/s41467-021-21821-02041-1723https://doaj.org/article/6a8ef38d436d4d3fbb7a5a30aa9a40f82021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21821-0https://doaj.org/toc/2041-1723The circadian factors BMAL1/CLOCK and REV-ERB are master regulators of the human liver transcriptome but their role in hepatitis B virus infection is largely unknown. Here, Zhuang et al. show that REV-ERB regulates hepatitis B virus entry and BMAL1 directly binds HBV DNA and activates viral genome transcription.Xiaodong ZhuangDonall FordeSenko TsukudaValentina D’ArienzoLaurent MaillyJames M. HarrisPeter A. C. WingHelene BorrmannMirjam SchillingAndrea MagriClaudia Orbegozo RubioRobert J. MaidstoneMudassar IqbalMiguel GarzonRosalba MinisiniMario PirisiSam ButterworthPeter BalfeDavid W. RayKoichi WatashiThomas F. BaumertJane A. McKeatingNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaodong Zhuang Donall Forde Senko Tsukuda Valentina D’Arienzo Laurent Mailly James M. Harris Peter A. C. Wing Helene Borrmann Mirjam Schilling Andrea Magri Claudia Orbegozo Rubio Robert J. Maidstone Mudassar Iqbal Miguel Garzon Rosalba Minisini Mario Pirisi Sam Butterworth Peter Balfe David W. Ray Koichi Watashi Thomas F. Baumert Jane A. McKeating Circadian control of hepatitis B virus replication
description	The circadian factors BMAL1/CLOCK and REV-ERB are master regulators of the human liver transcriptome but their role in hepatitis B virus infection is largely unknown. Here, Zhuang et al. show that REV-ERB regulates hepatitis B virus entry and BMAL1 directly binds HBV DNA and activates viral genome transcription.
format	article
author	Xiaodong Zhuang Donall Forde Senko Tsukuda Valentina D’Arienzo Laurent Mailly James M. Harris Peter A. C. Wing Helene Borrmann Mirjam Schilling Andrea Magri Claudia Orbegozo Rubio Robert J. Maidstone Mudassar Iqbal Miguel Garzon Rosalba Minisini Mario Pirisi Sam Butterworth Peter Balfe David W. Ray Koichi Watashi Thomas F. Baumert Jane A. McKeating
author_facet	Xiaodong Zhuang Donall Forde Senko Tsukuda Valentina D’Arienzo Laurent Mailly James M. Harris Peter A. C. Wing Helene Borrmann Mirjam Schilling Andrea Magri Claudia Orbegozo Rubio Robert J. Maidstone Mudassar Iqbal Miguel Garzon Rosalba Minisini Mario Pirisi Sam Butterworth Peter Balfe David W. Ray Koichi Watashi Thomas F. Baumert Jane A. McKeating
author_sort	Xiaodong Zhuang
title	Circadian control of hepatitis B virus replication
title_short	Circadian control of hepatitis B virus replication
title_full	Circadian control of hepatitis B virus replication
title_fullStr	Circadian control of hepatitis B virus replication
title_full_unstemmed	Circadian control of hepatitis B virus replication
title_sort	circadian control of hepatitis b virus replication
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6a8ef38d436d4d3fbb7a5a30aa9a40f8
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Circadian control of hepatitis B virus replication

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