Electrophysiology of the rhythmic defecation program in nematode Heterorhabditis megidis

Abstract The nervous system controls most rhythmic behaviors, with a remarkable exception. In Caenorhabditis elegans periodic defecation rhythm does not appear to involve the nervous system. Such oscillations are studied in detail with genetic and molecular biology tools. The small size of C. elegan...

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Autores principales:	Victor P. Kuznetsov, Georgy A. Slivko-Koltchik, Dmitry A. Voronov, Yuri V. Panchin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6a8f2ed04bc94cf3911035d2a9ffc102
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spelling	oai:doaj.org-article:6a8f2ed04bc94cf3911035d2a9ffc1022021-12-02T15:05:16ZElectrophysiology of the rhythmic defecation program in nematode Heterorhabditis megidis10.1038/s41598-017-18118-y2045-2322https://doaj.org/article/6a8f2ed04bc94cf3911035d2a9ffc1022017-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-18118-yhttps://doaj.org/toc/2045-2322Abstract The nervous system controls most rhythmic behaviors, with a remarkable exception. In Caenorhabditis elegans periodic defecation rhythm does not appear to involve the nervous system. Such oscillations are studied in detail with genetic and molecular biology tools. The small size of C. elegans cells impairs the use of standard electrophysiological methods. We studied a similar rhythmic pacemaker in the noticeably larger gut cells of Heterorhabditis megidis nematode. H. megidis defecation cycle is driven by a central pattern generator (CPG) associated with unusual all-or-none hyper-polarization “action potential”. The CPG cycle period depends on the membrane potential and CPG cycling also persisted in experiments where the membrane potential of gut cells was continuously clamped at steady voltage levels. The usual excitable tissue description does not include the endoderm or imply the generation of hyper-polarization spikes. The nematode gut cells activity calls for a reevaluation of the excitable cells definition.Victor P. KuznetsovGeorgy A. Slivko-KoltchikDmitry A. VoronovYuri V. PanchinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Victor P. Kuznetsov Georgy A. Slivko-Koltchik Dmitry A. Voronov Yuri V. Panchin Electrophysiology of the rhythmic defecation program in nematode Heterorhabditis megidis
description	Abstract The nervous system controls most rhythmic behaviors, with a remarkable exception. In Caenorhabditis elegans periodic defecation rhythm does not appear to involve the nervous system. Such oscillations are studied in detail with genetic and molecular biology tools. The small size of C. elegans cells impairs the use of standard electrophysiological methods. We studied a similar rhythmic pacemaker in the noticeably larger gut cells of Heterorhabditis megidis nematode. H. megidis defecation cycle is driven by a central pattern generator (CPG) associated with unusual all-or-none hyper-polarization “action potential”. The CPG cycle period depends on the membrane potential and CPG cycling also persisted in experiments where the membrane potential of gut cells was continuously clamped at steady voltage levels. The usual excitable tissue description does not include the endoderm or imply the generation of hyper-polarization spikes. The nematode gut cells activity calls for a reevaluation of the excitable cells definition.
format	article
author	Victor P. Kuznetsov Georgy A. Slivko-Koltchik Dmitry A. Voronov Yuri V. Panchin
author_facet	Victor P. Kuznetsov Georgy A. Slivko-Koltchik Dmitry A. Voronov Yuri V. Panchin
author_sort	Victor P. Kuznetsov
title	Electrophysiology of the rhythmic defecation program in nematode Heterorhabditis megidis
title_short	Electrophysiology of the rhythmic defecation program in nematode Heterorhabditis megidis
title_full	Electrophysiology of the rhythmic defecation program in nematode Heterorhabditis megidis
title_fullStr	Electrophysiology of the rhythmic defecation program in nematode Heterorhabditis megidis
title_full_unstemmed	Electrophysiology of the rhythmic defecation program in nematode Heterorhabditis megidis
title_sort	electrophysiology of the rhythmic defecation program in nematode heterorhabditis megidis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6a8f2ed04bc94cf3911035d2a9ffc102
work_keys_str_mv	AT victorpkuznetsov electrophysiologyoftherhythmicdefecationprograminnematodeheterorhabditismegidis AT georgyaslivkokoltchik electrophysiologyoftherhythmicdefecationprograminnematodeheterorhabditismegidis AT dmitryavoronov electrophysiologyoftherhythmicdefecationprograminnematodeheterorhabditismegidis AT yurivpanchin electrophysiologyoftherhythmicdefecationprograminnematodeheterorhabditismegidis
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Electrophysiology of the rhythmic defecation program in nematode Heterorhabditis megidis

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