B-CELL SUBPOPULATIONS OF PERIPHERAL BLOOD IN SYSTEMIC LUPUS ERYTHEMATOSUS

Distinct changes of B-cell subpopulations are observed in most systemic rheumatic diseases associated with polyclonal B cell hyperreactivity. Immunosuppressive and cytostatic therapy may also differentially influence B lymphocyte subsets in these. We studied subpopulations of B cells in systemic rhe...

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Autores principales:	A. I. Budkova, S. V. Lapin, M. K. Serebriakova, I. V. Kudryavtsev, I. N. Trishina, A. L. Maslyansky, A. A. Totolian
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2017
Materias:	systemic rheumatic diseases flow cytometry b-lymphocyte subpopulations Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/6a8f9d1cd6954dc0b9a41e5a3cb9afa5
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spelling	oai:doaj.org-article:6a8f9d1cd6954dc0b9a41e5a3cb9afa52021-11-18T08:03:46ZB-CELL SUBPOPULATIONS OF PERIPHERAL BLOOD IN SYSTEMIC LUPUS ERYTHEMATOSUS1563-06252313-741X10.15789/1563-0625-2017-2-175-184https://doaj.org/article/6a8f9d1cd6954dc0b9a41e5a3cb9afa52017-05-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1220https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XDistinct changes of B-cell subpopulations are observed in most systemic rheumatic diseases associated with polyclonal B cell hyperreactivity. Immunosuppressive and cytostatic therapy may also differentially influence B lymphocyte subsets in these. We studied subpopulations of B cells in systemic rheumatic patients along treatment with cytostatics. We analyzed B cell phenotypes in ninety-nine blood samples from the patients with systemic lupus erythematosus (SLE, n = 25), systemic sclerosis (n = 27), Sjogren’s syndrome (n = 47) in the course of their hospital treatment. Control group consisted of 49 healthy blood donors. Phenotyping of blood B-cell subpopulations was performed by means of flow cytometry (Beckman Coulter, USA). Naïve B-cell subpopulations in SLE patients who underwent cyclophosphan treatment, were underrepresented, if compared with normal control group, whereas plasmablast levels were increased irrespectively of medication mode. B cell population exhibits a natural heterogeneity, thus making it necessary to analyze distinct B cell subpopulations as independent functional units, when studying different rheumatic diseases. The levels of plasmablasts which are active antibody producers, remain high, despite immunosuppressive therapy performed in SLE. Thus, therapy targeted against certain B cell subsets, could be able to provide a more effective treatment for the patients with systemic rheumatic diseases.A. I. BudkovaS. V. LapinM. K. SerebriakovaI. V. KudryavtsevI. N. TrishinaA. L. MaslyanskyA. A. TotolianSPb RAACIarticlesystemic rheumatic diseasesflow cytometryb-lymphocyte subpopulationsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 19, Iss 2, Pp 175-184 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	systemic rheumatic diseases flow cytometry b-lymphocyte subpopulations Immunologic diseases. Allergy RC581-607
spellingShingle	systemic rheumatic diseases flow cytometry b-lymphocyte subpopulations Immunologic diseases. Allergy RC581-607 A. I. Budkova S. V. Lapin M. K. Serebriakova I. V. Kudryavtsev I. N. Trishina A. L. Maslyansky A. A. Totolian B-CELL SUBPOPULATIONS OF PERIPHERAL BLOOD IN SYSTEMIC LUPUS ERYTHEMATOSUS
description	Distinct changes of B-cell subpopulations are observed in most systemic rheumatic diseases associated with polyclonal B cell hyperreactivity. Immunosuppressive and cytostatic therapy may also differentially influence B lymphocyte subsets in these. We studied subpopulations of B cells in systemic rheumatic patients along treatment with cytostatics. We analyzed B cell phenotypes in ninety-nine blood samples from the patients with systemic lupus erythematosus (SLE, n = 25), systemic sclerosis (n = 27), Sjogren’s syndrome (n = 47) in the course of their hospital treatment. Control group consisted of 49 healthy blood donors. Phenotyping of blood B-cell subpopulations was performed by means of flow cytometry (Beckman Coulter, USA). Naïve B-cell subpopulations in SLE patients who underwent cyclophosphan treatment, were underrepresented, if compared with normal control group, whereas plasmablast levels were increased irrespectively of medication mode. B cell population exhibits a natural heterogeneity, thus making it necessary to analyze distinct B cell subpopulations as independent functional units, when studying different rheumatic diseases. The levels of plasmablasts which are active antibody producers, remain high, despite immunosuppressive therapy performed in SLE. Thus, therapy targeted against certain B cell subsets, could be able to provide a more effective treatment for the patients with systemic rheumatic diseases.
format	article
author	A. I. Budkova S. V. Lapin M. K. Serebriakova I. V. Kudryavtsev I. N. Trishina A. L. Maslyansky A. A. Totolian
author_facet	A. I. Budkova S. V. Lapin M. K. Serebriakova I. V. Kudryavtsev I. N. Trishina A. L. Maslyansky A. A. Totolian
author_sort	A. I. Budkova
title	B-CELL SUBPOPULATIONS OF PERIPHERAL BLOOD IN SYSTEMIC LUPUS ERYTHEMATOSUS
title_short	B-CELL SUBPOPULATIONS OF PERIPHERAL BLOOD IN SYSTEMIC LUPUS ERYTHEMATOSUS
title_full	B-CELL SUBPOPULATIONS OF PERIPHERAL BLOOD IN SYSTEMIC LUPUS ERYTHEMATOSUS
title_fullStr	B-CELL SUBPOPULATIONS OF PERIPHERAL BLOOD IN SYSTEMIC LUPUS ERYTHEMATOSUS
title_full_unstemmed	B-CELL SUBPOPULATIONS OF PERIPHERAL BLOOD IN SYSTEMIC LUPUS ERYTHEMATOSUS
title_sort	b-cell subpopulations of peripheral blood in systemic lupus erythematosus
publisher	SPb RAACI
publishDate	2017
url	https://doaj.org/article/6a8f9d1cd6954dc0b9a41e5a3cb9afa5
work_keys_str_mv	AT aibudkova bcellsubpopulationsofperipheralbloodinsystemiclupuserythematosus AT svlapin bcellsubpopulationsofperipheralbloodinsystemiclupuserythematosus AT mkserebriakova bcellsubpopulationsofperipheralbloodinsystemiclupuserythematosus AT ivkudryavtsev bcellsubpopulationsofperipheralbloodinsystemiclupuserythematosus AT intrishina bcellsubpopulationsofperipheralbloodinsystemiclupuserythematosus AT almaslyansky bcellsubpopulationsofperipheralbloodinsystemiclupuserythematosus AT aatotolian bcellsubpopulationsofperipheralbloodinsystemiclupuserythematosus
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B-CELL SUBPOPULATIONS OF PERIPHERAL BLOOD IN SYSTEMIC LUPUS ERYTHEMATOSUS

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