Evaluation of PD-L1 and tumor infiltrating lymphocytes in paired pretreatment biopsies and post neoadjuvant chemotherapy surgical specimens of breast carcinoma

Abstract Herein it was evaluated the impact of PD-L1 immunohistochemical expression and stromal tumor-infiltrating lymphocyte (sTIL) counts in pretreatment needle core biopsy on response to neoadjuvant chemotherapy (NACT) for patients with breast carcinomas (BC). In 127 paired pre- and post-NACT BC...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lucas Grecco Hoffmann, Luis Otavio Sarian, José Vassallo, Geisilene Russano de Paiva Silva, Susana Oliveira Botelho Ramalho, Amanda Canato Ferracini, Karina da Silva Araujo, Rodrigo Menezes Jales, Deayra Emyle Figueira, Sophie Derchain
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6a90dcf15a63432886ba86d132fec09e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6a90dcf15a63432886ba86d132fec09e
record_format	dspace
spelling	oai:doaj.org-article:6a90dcf15a63432886ba86d132fec09e2021-11-21T12:20:57ZEvaluation of PD-L1 and tumor infiltrating lymphocytes in paired pretreatment biopsies and post neoadjuvant chemotherapy surgical specimens of breast carcinoma10.1038/s41598-021-00944-w2045-2322https://doaj.org/article/6a90dcf15a63432886ba86d132fec09e2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-00944-whttps://doaj.org/toc/2045-2322Abstract Herein it was evaluated the impact of PD-L1 immunohistochemical expression and stromal tumor-infiltrating lymphocyte (sTIL) counts in pretreatment needle core biopsy on response to neoadjuvant chemotherapy (NACT) for patients with breast carcinomas (BC). In 127 paired pre- and post-NACT BC specimens, immunohistochemical expression of PD-L1 was evaluated in stroma and in neoplastic cells. In the same samples sTILs were semi-quantified in tumor stroma. Post-NACT specimens were histologically rated as having residual cancer burden (RCB of any degree), or with complete pathological response (pCR). PD-L1 expression and higher sTIL counts were associated with histological grade 3 BC. PD-L1 expression was also associated with the non-luminal-HER2+ and triple negative immunohistochemical profiles of BC. Pathological complete response was associated with histological grade 3 tumors, and with the non-luminal-HER2+ and triple negative profiles. Additionally, our results support an association between PD-L1 expression and pCR to NACT. It was also observed that there is a trend to reduction of sTIL counts in the post-NACT specimens of patients with pCR. Of note, PD-L1 was expressed in half of the hormone receptor positive cases, a finding that might expand the potential use of immune checkpoint inhibitors for BC patients.Lucas Grecco HoffmannLuis Otavio SarianJosé VassalloGeisilene Russano de Paiva SilvaSusana Oliveira Botelho RamalhoAmanda Canato FerraciniKarina da Silva AraujoRodrigo Menezes JalesDeayra Emyle FigueiraSophie DerchainNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lucas Grecco Hoffmann Luis Otavio Sarian José Vassallo Geisilene Russano de Paiva Silva Susana Oliveira Botelho Ramalho Amanda Canato Ferracini Karina da Silva Araujo Rodrigo Menezes Jales Deayra Emyle Figueira Sophie Derchain Evaluation of PD-L1 and tumor infiltrating lymphocytes in paired pretreatment biopsies and post neoadjuvant chemotherapy surgical specimens of breast carcinoma
description	Abstract Herein it was evaluated the impact of PD-L1 immunohistochemical expression and stromal tumor-infiltrating lymphocyte (sTIL) counts in pretreatment needle core biopsy on response to neoadjuvant chemotherapy (NACT) for patients with breast carcinomas (BC). In 127 paired pre- and post-NACT BC specimens, immunohistochemical expression of PD-L1 was evaluated in stroma and in neoplastic cells. In the same samples sTILs were semi-quantified in tumor stroma. Post-NACT specimens were histologically rated as having residual cancer burden (RCB of any degree), or with complete pathological response (pCR). PD-L1 expression and higher sTIL counts were associated with histological grade 3 BC. PD-L1 expression was also associated with the non-luminal-HER2+ and triple negative immunohistochemical profiles of BC. Pathological complete response was associated with histological grade 3 tumors, and with the non-luminal-HER2+ and triple negative profiles. Additionally, our results support an association between PD-L1 expression and pCR to NACT. It was also observed that there is a trend to reduction of sTIL counts in the post-NACT specimens of patients with pCR. Of note, PD-L1 was expressed in half of the hormone receptor positive cases, a finding that might expand the potential use of immune checkpoint inhibitors for BC patients.
format	article
author	Lucas Grecco Hoffmann Luis Otavio Sarian José Vassallo Geisilene Russano de Paiva Silva Susana Oliveira Botelho Ramalho Amanda Canato Ferracini Karina da Silva Araujo Rodrigo Menezes Jales Deayra Emyle Figueira Sophie Derchain
author_facet	Lucas Grecco Hoffmann Luis Otavio Sarian José Vassallo Geisilene Russano de Paiva Silva Susana Oliveira Botelho Ramalho Amanda Canato Ferracini Karina da Silva Araujo Rodrigo Menezes Jales Deayra Emyle Figueira Sophie Derchain
author_sort	Lucas Grecco Hoffmann
title	Evaluation of PD-L1 and tumor infiltrating lymphocytes in paired pretreatment biopsies and post neoadjuvant chemotherapy surgical specimens of breast carcinoma
title_short	Evaluation of PD-L1 and tumor infiltrating lymphocytes in paired pretreatment biopsies and post neoadjuvant chemotherapy surgical specimens of breast carcinoma
title_full	Evaluation of PD-L1 and tumor infiltrating lymphocytes in paired pretreatment biopsies and post neoadjuvant chemotherapy surgical specimens of breast carcinoma
title_fullStr	Evaluation of PD-L1 and tumor infiltrating lymphocytes in paired pretreatment biopsies and post neoadjuvant chemotherapy surgical specimens of breast carcinoma
title_full_unstemmed	Evaluation of PD-L1 and tumor infiltrating lymphocytes in paired pretreatment biopsies and post neoadjuvant chemotherapy surgical specimens of breast carcinoma
title_sort	evaluation of pd-l1 and tumor infiltrating lymphocytes in paired pretreatment biopsies and post neoadjuvant chemotherapy surgical specimens of breast carcinoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6a90dcf15a63432886ba86d132fec09e
work_keys_str_mv	AT lucasgreccohoffmann evaluationofpdl1andtumorinfiltratinglymphocytesinpairedpretreatmentbiopsiesandpostneoadjuvantchemotherapysurgicalspecimensofbreastcarcinoma AT luisotaviosarian evaluationofpdl1andtumorinfiltratinglymphocytesinpairedpretreatmentbiopsiesandpostneoadjuvantchemotherapysurgicalspecimensofbreastcarcinoma AT josevassallo evaluationofpdl1andtumorinfiltratinglymphocytesinpairedpretreatmentbiopsiesandpostneoadjuvantchemotherapysurgicalspecimensofbreastcarcinoma AT geisilenerussanodepaivasilva evaluationofpdl1andtumorinfiltratinglymphocytesinpairedpretreatmentbiopsiesandpostneoadjuvantchemotherapysurgicalspecimensofbreastcarcinoma AT susanaoliveirabotelhoramalho evaluationofpdl1andtumorinfiltratinglymphocytesinpairedpretreatmentbiopsiesandpostneoadjuvantchemotherapysurgicalspecimensofbreastcarcinoma AT amandacanatoferracini evaluationofpdl1andtumorinfiltratinglymphocytesinpairedpretreatmentbiopsiesandpostneoadjuvantchemotherapysurgicalspecimensofbreastcarcinoma AT karinadasilvaaraujo evaluationofpdl1andtumorinfiltratinglymphocytesinpairedpretreatmentbiopsiesandpostneoadjuvantchemotherapysurgicalspecimensofbreastcarcinoma AT rodrigomenezesjales evaluationofpdl1andtumorinfiltratinglymphocytesinpairedpretreatmentbiopsiesandpostneoadjuvantchemotherapysurgicalspecimensofbreastcarcinoma AT deayraemylefigueira evaluationofpdl1andtumorinfiltratinglymphocytesinpairedpretreatmentbiopsiesandpostneoadjuvantchemotherapysurgicalspecimensofbreastcarcinoma AT sophiederchain evaluationofpdl1andtumorinfiltratinglymphocytesinpairedpretreatmentbiopsiesandpostneoadjuvantchemotherapysurgicalspecimensofbreastcarcinoma
_version_	1718419070019174400

Evaluation of PD-L1 and tumor infiltrating lymphocytes in paired pretreatment biopsies and post neoadjuvant chemotherapy surgical specimens of breast carcinoma

Ejemplares similares